Month: March 2021

In an article, author is Hamdy, Rania, once mentioned the application of 85-42-7, Name: Hexahydroisobenzofuran-1,3-dione, Name is Hexahydroisobenzofuran-1,3-dione, molecular formula is C8H10O3, molecular weight is 154.1632, MDL number is MFCD00064863, category is thiazolidines. Now introduce a scientific discovery about this category.

Design and synthesis of new drugs inhibitors of Candida albicans hyphae and biofilm formation by upregulating the expression of TUP1 transcription repressor gene

Candida albicans is a common human fungal pathogen that causes disease ranging from superficial to lethal infections. C. albicans grows as budding yeast which can transform into hyphae in response to various environmental or biological stimuli. Although both forms have been associated with virulence, the hyphae form is responsible for the formation of multi-drug resistance biofilm. Here, new compounds were designed to selectively inhibit C. albicans hyphae formation without affecting human cells to afford sufficient safety. The newly designed 5-[3-substitued-4-(4-substituedbenzyloxy)-benzylidene]-2-thioxo-thiazolidin-4-one derivatives, named SR, showed very specific and effective inhibition activity against C. albicans hyphae formation. SR compounds caused hyphae inhibition activity at concentrations 10-40 fold lower than the concentration required to inhibit Candida yeast and bacterial growths. The anti-hyphae inhibition activities of SR compounds were via activation of the hyphae transcription repressor gene, TUP1. Correlation studies between the expression of TUP1 gene and the activity of SR compounds confirmed that the anti-C. albicans activities of SR compounds were via inhibition of hyphae formation. The newly designed SR compounds showed 10-40% haemolytic activity on human erythrocytes when compared to 100% haemolysis by 0.1% triton employed as positive control. Furthermore, theoretical prediction of absorption, distribution, metabolism, excretion, and toxicity (ADMET) of SR compounds confirmed their safety, efficient metabolism and possible oral bioavailability. With the minimal toxicity and significant activity of the newly-designed SR compounds, a future optimization of pharmaceutical formulation may develop a promising inhibitor of hyphal formation not only for C. albicans but also for other TUP1- dependent dimorphic fungal infections.

If you are interested in 85-42-7, you can contact me at any time and look forward to more communication. Name: Hexahydroisobenzofuran-1,3-dione.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Name: 2,2-Bis(hydroxymethyl)butyric acid, 10097-02-6, Name is 2,2-Bis(hydroxymethyl)butyric acid, molecular formula is C6H12O4, belongs to thiazolidines compound. In a document, author is Kuila, Bilash, introduce the new discover.

A facile and highly chemoselective synthesis of 1-thia-3a,6-diaza-benzo[e]azulen-3-ones by 7-exo-dig/trig halocyclizations

This manuscript describes a study on relatively unexplored halogen mediated 7-exo-dig/trig cyclization reactions of 2-(2-amino-aryl)-3-prop-2-ynyl/allyl-thiazolidin-4-ones for the formation of thiazole condensed 1,4-benzodiazepines in good yields. The reactions are facile, chemoselective and involve the use of simple substrates leading to synthesis of diversely functionalized 1,4-benzodiazepines. The synthesis of such condensed 1,4-benzodiazepines is important in terms of their usefulness as biological active agents.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 10097-02-6. Name: 2,2-Bis(hydroxymethyl)butyric acid.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is an experimental science, Quality Control of Dimethyl adipate, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 627-93-0, Name is Dimethyl adipate, molecular formula is C8H14O4, belongs to thiazolidines compound. In a document, author is Jiao, Lihui.

Catalytic Asymmetric Conjugate Addition and Sulfenylation of Diarylthiazolidin-2,4-diones

This work reports the first application of diarylthiazolidin-2,4-diones as nucleophiles in asymmetric catalysis. By utilizing chiral amino acid-based (thio)urea tertiary amines as the catalysts, we successively established asymmetric conjugate addition to nitroolefins and sulfenylation to N-(sulfanyl)-succinimides of diarylthiazolidin-2,4diones. Two series of biologically important 5-aryl-5-substituted thiazolidin-2,4-diones were obtained with high enantio- and diastereoselectivities (up to >99% ee and >19:1 dr). The enantio enriched adducts were found to show satisfactory anticancer activities against three different cancer cell lines using the MTT assay. All of these successes depended on the development of a general and expedient synthetic strategy to provide diverse 5H-thiazolidin-2,4-diones.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 627-93-0, in my other articles. Quality Control of Dimethyl adipate.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 627-93-0, Name is Dimethyl adipate, molecular formula is , belongs to thiazolidines compound. In a document, author is Irfan, Muhammad, Category: thiazolidines.

Tuning the Optoelectronic Properties of Naphtho-Dithiophene-Based A-D-A Type Small Donor Molecules for Bulk Hetero-Junction Organic Solar Cells

Four acceptor-donor-acceptor (A-D-A) type small molecules using naphtho-dithiophene as central building block, trithiophene as -bridges, malononitrile and 2-Thioxo-thiazolidin-4-one as end acceptor groups were designed by using density functional theory (DFT) and investigated as donor materials for organic solar cells (OSCs). The effects of end acceptor groups on absorption, charge transport, morphology, energy level and photovoltaic properties of the molecules were investigated and compared with reference molecule (R1= NDTP-CNCOO). These designed molecules showed relatively low HOMO levels of -5.46 to -5.56eV, strong absorption between 440-650nm by using chloroform as solvent. The designed donor molecules have an excellent electron mobility from 0.0161 to 0.0201V, hole mobility from 0.0275 to 0.0307V and open circuit voltage (Voc) from 1.76 to 1.86V. This study revealed that the designed donor materials are suitable and recommended for high performance organic solar cell devices.

If you are hungry for even more, make sure to check my other article about 627-93-0, Category: thiazolidines.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 141-84-4, Name is Rhodanine, SMILES is O=C1CSC(=S)N1, belongs to thiazolidines compound. In a document, author is Mamedov, I. G., introduce the new discover, Application In Synthesis of Rhodanine.

SOME ACETOPHENONE DERIVATIVES AS CORROSION INHIBITORS

The inhibition activities of 2-hydroxy-5-methylacetophenone thiosemicarbazone (1), (Z)-2-(((E)-1-(2-hydroxy-5-methylphenyl)ethylidene)hydrazono)thiazolidin-4-one (2), (E)-3-(2-hydroxy-54(E)-phenyldiazenyl)phenyl)-1-phenylprop-2-en-1-one (3), (E)-1-(4-bromophenyl)-3- (2-hydroxy-5-((E)-phenyldiazenyl)phenyl)prop-2-en-1-one (4), (E)-5-(2-hydroxy-5- (phenyldiazenyl)phenyl)-3-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide (5), (E)-3-(4-bromophenyl)-5-(2-hydroxy-5-(phenyldiazenyl)phenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide (6), 2, 2 ‘-((1 E, 1’E)-(ethane- 1, 2-diylbis(azanylylidene))bis (methanylylidene))bi s (4- ((E)- phenyldiazenyl)phenol (7) and 24(Z)-2-hydroxy-54(E)-phenyldiazenyl)benzylidene)hydrazine-1-carbothioamide (8) were explored by means of weight loss measurements for mild St-3 specimen in brine-kerosene solution. The corrosion rates of the St-3 drops as the inhibitor concentration increases together with increase of inhibition efficiencies. Thermodynamic parameters of adsorption on the St-3 surface at different concentrations were calculated.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 141-84-4 is helpful to your research. Application In Synthesis of Rhodanine.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 94-41-7, Name is Chalcone, formurla is C15H12O. In a document, author is Djafri, Ahmed, introducing its new discovery. Product Details of 94-41-7.

Crystal and molecular structure of (2Z,5Z)-3-(2-methoxyphenyl)-2-[(2-methoxyphenyl)imino]-5-(4-nitrobenzylidene)thiazolidin-4-one

In the title compound, C24H19N3O5S, the thiazole ring (r. m. s. deviation = 0.012 angstrom) displays a planar geometry and is surrounded by three fragments, two methoxyphenyl and one nitrophenyl. The thiazole ring is almost in the same plane as the nitrophenyl ring, making a dihedral angle of 20.92 (6)degrees. The two methoxyphenyl groups are perpendicular to the thiazole ring [dihedral angles of 79.29 (6) and 71.31 (7)degrees and make a dihedral angle of 68.59 (7)degrees. The molecule exists in an Z, Z conformation with respect to the C N imine bond. In the crystal, a series of C-H center dot center dot center dot N, C-H center dot center dot center dot O and C-H center dot center dot center dot S hydrogen bonds, augmented by several pi-pi (ring) interactions, produce a three-dimensional architecture of molecules stacked along the b-axis direction. The experimentally derived structure is compered with that calculated theoretically using DFT(B3YLP) methods.

If you are hungry for even more, make sure to check my other article about 94-41-7, Product Details of 94-41-7.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 29681-57-0, Name is tert-Butyldimethylsilane, SMILES is C[SiH](C(C)(C)C)C, belongs to thiazolidines compound. In a document, author is Hamama, Wafaa S., introduce the new discover, Category: thiazolidines.

Synthesis, DFT Study, and Antitumor Activity of Some New Heterocyclic Compounds Incorporating Isoxazole Moiety

Thiazolidin-4-one derivative 3 was synthesized by the transformation of chloroacetamide derivative 2 with NH4SCN. The condensation of 3 with p-anisaldehyde afforded the corresponding arylidene derivative 4. Also, the alkylation of chloroacetamide derivative 2 with different heterocyclic compounds was investigated. Annulation of 5-amino-3-methylisoxazole (1) with alpha-halocarbonyl compounds 12 and 14 furnished pyrrolo[3,2-d]isoxazole and isoxazolo[5,4-b]azepin-6-one derivatives 13 and 15, respectively, while reaction of 1 with 1-chloro-4-(chloromethyl)benzene gave the monoalkylated product 17. The newly synthesized compounds were screened for their antitumor activity, and the geometry optimizations are in a good agreement with the experimentally observed data.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 29681-57-0 is helpful to your research. Category: thiazolidines.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 2421-28-5, Name is Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride, molecular formula is C17H6O7. In an article, author is Nuriye, Ahmed,once mentioned of 2421-28-5, Name: Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride.

Crystal structures of two thiazolidinone derivatives bearing a trichloromethyl substituent at the 2-position

The title compounds 2-trichloromethyl-3-phenyl-1,3-thiazolidin-4-one (C10H8Cl3NOS), 1 and 3-(4-chlorophenyl)-2-trichloromethyl-1,3-thiazolidin-4-one (C10H7Cl4NOS) 2, are structurally related with one atom substitution difference in the para position of the benzene ring. In both structures, the thiazolidinone ring adopts an envelope conformation with the S atom as the flap. The dihedral angles between the rings [48.72 (11) in 1 and 48.42 (9)degrees in 2] are very similar and the molecules are almost superimposable. In both crystal structures, C-H center dot center dot center dot O ‘head-to-tail’ interactions between the chiral carbon atoms and the thiazolidinone oxygen atoms result in infinite monochiral chains along the direction of the shortest unit-cell parameter, namely a in 1 and b in 2. C-H center dot center dot center dot pi interactions between the thiazolidinone carbon atom at the 4-position and the phenyl ring of the neighboring enantiomer also help to stabilize the packing in each case, although the crystals are not isostructural.

If you¡¯re interested in learning more about 2421-28-5. The above is the message from the blog manager. Name: Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In an article, author is Sasaki, Ryosuke, once mentioned the application of 593-85-1, HPLC of Formula: C3H12N6O3, Name is guanidinecarbonate, molecular formula is C3H12N6O3, molecular weight is 180.1658, MDL number is MFCD00013029, category is thiazolidines. Now introduce a scientific discovery about this category.

Chiral syntheses of methyl (R)-2-Sulfanylcarboxylic esters and acids with optical purity determination using HPLC

Accessible chiral syntheses of 3 types of (R)-2-sulfanylcarboxylic esters and acids were performed: (R)-2-sulfanylpropanoic (thiolactic) ester (53%, 98%ee) and acid (39%, 96%ee), (R)-2-sulfanylsucciinic diester (59%, 96%ee), and (R)-2-mandelic ester (78%, 90%ee) and acid (59%, 96%ee). The present practical and robust method involves (i) clean S(N)2 displacement of methanesulfonates of (S)-2-hydroxyesters by using commercially available AcSK with tris(2-[2-methoxyethoxy])ethylamine and (ii) sufficiently mild deacetylation. The optical purity was determined by the corresponding (2R,5R)-trans-thiazolidin-4-one and (2S,5R)-cis-thiazolidin-4-one derivatives based on accurate high-performance liquid chromatography analysis with high-resolution efficiency. Compared with the reported method utilizing AcSCs (generated from AcSH and CsCO3), the present method has several advantages, that is, the use of odorless AcCOSK reagent, reasonable reaction velocity, isolation procedure, and accurate, reliable optical purity determination. The use of accessible AcSK has advantages because of easy-to-handle odorless and hygroscopic solid that can be used in a bench-top procedure. The Ti(OiPr)(4) catalyst promoted smooth trans-cyclo-condensation to afford (2R,5R)-trans-thiazolidin-4-one formation of (R)-2-sulfanylcarboxylic esters with available N-(benzylidene)methylamine under neutral conditions without any racemization, whereas (2S,5R)-cis-thiazollidin-4-ones were obtained via cis-cyclo-condensation and no catalysts. Direct high-performance liquid chromatography analysis of methyl (R)-mandelate was also performed; however, the resolution efficiency was inferior to that of the thaizolidin-4-one derivatizations.

If you are interested in 593-85-1, you can contact me at any time and look forward to more communication. HPLC of Formula: C3H12N6O3.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 542-05-2, Name is 3-Oxopentanedioic acid, molecular formula is C5H6O5. In an article, author is Pachuta-Stec, Anna,once mentioned of 542-05-2, Safety of 3-Oxopentanedioic acid.

Design, synthesis, structure elucidation and in vitro antiviral and antimicrobial evaluation

In this study, we described the synthesis of the derivatives of thiosemicarbazide, dicarboximide, 1,2,4-triazole-5-thione and 4-oxo-1,3-thiazolidine. Two different dicarboxylic acid anhydrides reacted with 4-substituted-3-thiosemicarbazide, and derivatives of thiosemicarbazide and dicarboximide were obtained. Next, cyclization reaction of dicarboximide derivatives in alkaline media was used to prepare 1,2,4-triazole-5-thione. The 4-oxo-1,3-thiazolidine was synthesized by the reaction of dicarboximide with ethyl bromoacetate. All obtained derivatives were analysed by H-1 and C-13 NMR spectra, and for one compound, the X-ray crystallography was done. Antimicrobial, antiviral and in vitro evaluations of cytotoxicity were examined. According to the preliminary antiviral screening, compounds 3 and 4 presented the antiviral activity against HSV-1 and CVB3. Additionally, compound 3 shows selective in vitro toxic effect against human epithelial cells FaDu, without affecting normal animal cell line (Vero). The same derivatives 3 and 4 also displayed a wide spectrum of antimicrobial activity against reference microorganisms and indicated both antibacterial and antifungal potential activities.

If you¡¯re interested in learning more about 542-05-2. The above is the message from the blog manager. Safety of 3-Oxopentanedioic acid.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com