Month: October 2021

Ryoo, CH; Choi, YH; Cheon, JE; Yoon, SH; Kang, HR; Park, SJ; Lee, W in [Ryoo, Chang Hyun; Choi, Young Hun; Cheon, Jung-Eun; Yoon, Soon Ho; Park, Sae-Jin; Lee, Whal] Seoul Natl Univ Hosp, Dept Radiol, 101 Daehak Ro, Seoul 03080, South Korea; [Choi, Young Hun; Cheon, Jung-Eun; Yoon, Soon Ho; Lee, Whal] Seoul Natl Univ, Coll Med, Dept Radiol, Seoul, South Korea; [Cheon, Jung-Eun; Lee, Whal] Seoul Natl Univ, Med Res Ctr, Inst Radiat Med, Seoul, South Korea; [Kang, Hye-Ryun] Seoul Natl Univ Hosp, Drug Safety Monitoring Ctr, Seoul, South Korea; [Kang, Hye-Ryun] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; [Kang, Hye-Ryun] Seoul Natl Univ, Med Res Ctr, Inst Allergy & Clin Immunol, Seoul, South Korea published Preventive Effect of Changing Contrast Media in Patients With A Prior Mild Immediate Hypersensitivity Reaction to Gadolinium-Based Contrast Agent in 2019.0, Cited 22.0. Recommanded Product: 78-39-7. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7.

Objectives Currently, the prevention of recurrent immediate hypersensitivity reactions (HSRs) to contrast media (CM) requests premedication and changing the culprit contrast agent. However, strategies for the prevention of immediate HSRs to gadolinium-based magnetic resonance contrast agents (GBCAs) have not yet been established. This study aimed to evaluate the effectiveness of changing the contrast agent and single-dose premedication for HSR recurrence prevention in patients with a history of mild immediate HSR to GBCA. Materials and Methods The outcomes of patients with mild immediate HSR to GBCA who subsequently underwent enhanced magnetic resonance imaging between October 2012 and July 2017 were analyzed. The institutional CM monitoring system was retrospectively reviewed, and data on the application of premedication and choice of CM were obtained. Gadolinium-based magnetic resonance contrast agents were classified into 3 classes according to their molecular structure (macrocyclic ionic, macrocyclic nonionic, and linear ionic). Intravenous chlorpheniramine 4 mg, 30 minutes before the GBCA administration, or intravenous methylprednisolone sodium succinate 40 mg plus chlorpheniramine 4 mg, 1 hour before the GBCA administration, was administrated as premedication regimen. Recurrence rates of immediate HSR were compared according to prevention strategies. Results A total of 185 patients with a history of mild immediate HSR to GBCA were re-exposed to GBCA 397 times during the study period. The overall recurrence rate was 19.6% (78/397). Changing the culprit GBCA significantly reduced the recurrence rate, compared with reusing the culprit GBCA (6.9%, 9/130 and 25.8%, 69/267; P < 0.001). The recurrence rate was lowest when the GBCA was changed to a different molecular structure class from the culprit agent, followed by changing to CM with the same molecular structure and reusing the culprit GBCA (6.2%, 7/113 vs 11.8%, 2/17 vs 25.8%, 69/267; P < 0.001 with chi(2) test for trend). Single-dose premedication demonstrated no significant prophylactic effect on recurrence (20.4%, 17/98 vs 17.3%, 61/299 with and without premedication, respectively; P = 0.509). Premedication in addition to changing CM also showed no additional prophylactic effect (7.2%, 7/97 and 6.1%, 2/33, respectively; P = 0.821). Conclusions Changing the CM from the culprit agent could reduce the chance of HSR recurrence in patients with prior mild immediate HSR to GBCA, especially when the CM was changed to one of a different molecular structure class. However, single-dose premedication administration did not show significant HSR recurrence rate difference. Recommanded Product: 78-39-7. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Ryoo, CH; Choi, YH; Cheon, JE; Yoon, SH; Kang, HR; Park, SJ; Lee, W or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In 2021.0 CHEM BIOL DRUG DES published article about FEBRIFUGINE; INHIBITORS; CHEMISTRY; UPDATE in [Prinsloo, Izak F.] North West Univ, Sch Pharm, Pharmaceut Chem, Potchefstroom, South Africa; [Zuma, Nonkululeko H.; Aucamp, Janine; N’Da, David D.] North West Univ, Ctr Excellence Pharmaceut Sci, ZA-2520 Potchefstroom, South Africa in 2021.0, Cited 32.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7. Computed Properties of C8H18O3

Currently available drugs being used to treat leishmaniasis have several shortcomings, including high toxicity, drug administration that requires hospitalization, and the emergence of parasite resistance against clinically used drugs. As a result, there is a dire need for the development of new antileishmanial drugs that are safe, affordable, and efficient. In this study, two new series of synthesized quinazolinone derivatives were investigated as potential future antileishmanial agents, by assessing their activities against theLeishmania(L.)donovaniandL. majorspecies. The cytotoxicity profiles of these derivatives were assessed in vitro on Vero cells. The compounds were found to be safer and without any toxic activities against mammalian cells, compared to the reference drug, halofuginone, a clinical derivative of febrifugine. However, they had demonstrated poor antileishmanial growth inhibition efficacies. The two compounds that had been found the most active were the mono quinazolinone2dand the bisquinazolinone5bwith growth inhibitory efficacies of 35% and 29% for theL. majorandL. donovani9515 promastigotes, respectively. These outcomes had suggested structural redesign,inter aliathe inclusion of polar groups on the quinazolinone ring, to potentially generate novel quinazolinone derivatives, endowed with effective antileishmanial potential.

About 1,1,1-Triethoxyethane, If you have any questions, you can contact Prinsloo, IF; Zuma, NH; Aucamp, J; N’Da, DD or concate me.. Computed Properties of C8H18O3

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article TMPE Derived from Saffron Natural Monoterpene as Cytotoxic and Multidrug Resistance Reversing Agent in Colon Cancer Cells WOS:000585561500001 published article about P-GLYCOPROTEIN; DOXORUBICIN; DITERPENES; TERPENOIDS; COMBINATIONS; DIGITONIN; THYMOL in [Sroda-Pomianek, Kamila; Palko-Labuz, Anna; Pola, Andrzej; Wesolowska, Olga] Wroclaw Med Univ, Dept Biophys & Neurobiol, Ul Chalubinskiego 3, PL-50368 Wroclaw, Poland; [Ferens-Sieczkowska, Miroslawa; Koziol, Agata] Wroclaw Med Univ, Dept Chem & Immunochem, Ul M Sklodowskiej Curie 48-50, PL-50369 Wroclaw, Poland in 2020.0, Cited 52.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7. Product Details of 78-39-7

Terpenes constitute one of the largest groups of natural products. They exhibit a wide range of biological activities including antioxidant, anticancer, and drug resistance modulating properties. Saffron extract and its terpene constituents have been demonstrated to be cytotoxic against various types of cancer cells, including breast, liver, lung, pancreatic, and colorectal cancer. In the present work, we have studied anticancer properties of TMPE, a newly synthesized monoterpene derivative of beta-cyclocitral-the main volatile produced by the stigmas of unripe crocuses. TMPE presented selective cytotoxic activity to doxorubicin-resistant colon cancer cells and was identified to be an effective MDR modulator in doxorubicin-resistant cancer cells. Synergy between this derivative and doxorubicin was observed. Most probably, TMPE inhibited transport activity of ABCB1 protein without affecting its expression level. Analysis of TMPE physicochemical parameters suggested it was not likely to be transported by ABCB1. Molecular modeling showed TMPE being more reactive molecule than the parental compound-beta-cyclocitral. Analysis of electrostatic potential maps of both compounds prompted us to hypothesize that reduced reactivity as well as susceptibility to electrophilic attack were related to the lower general toxicity of beta-cyclocitral. All of the above pointed to TMPE as an interesting candidate molecule for MDR reversal in cancer cells.

Product Details of 78-39-7. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Sroda-Pomianek, K; Palko-Labuz, A; Pola, A; Ferens-Sieczkowska, M; Wesolowska, O; Koziol, A or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In 2020.0 J ORG CHEM published article about ENANTIOSELECTIVE TOTAL SYNTHESES; MITSUNOBU REACTION; AKUAMMILINE ALKALOIDS; INDOLE ALKALOIDS; FORMAL SYNTHESIS; (+)-ASPIDOSPERMIDINE; REARRANGEMENT in [Zhou, Yi-Guo; Wong, Henry N. C.; Peng, Xiao-Shui] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong 100051, Peoples R China; [Zhou, Yi-Guo; Wong, Henry N. C.; Peng, Xiao-Shui] Chinese Univ Hong Kong, State Key Lab Synthet Chem, Shatin, Hong Kong 100051, Peoples R China; [Wong, Henry N. C.; Peng, Xiao-Shui] Chinese Univ Hong Kong Shenzhen, Sch Sci & Engn, Shenzhen 518172, Peoples R China; [Wong, Henry N. C.; Peng, Xiao-Shui] Chinese Univ Hong Kong, Shenzhen Municipal Key Lab Chem Synth Med Organ M, Shenzhen Res Inst, Shenzhen 518507, Peoples R China in 2020.0, Cited 33.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7. Recommanded Product: 1,1,1-Triethoxyethane

The total syntheses of Aspidosperma and Kopsia alkaloids (-)-deoxoapodine, (-)-kopsifoline D, and (-)-beninine are described through a domino deprotection-Michael addition-nucleophilic substitution protocol to assemble the core framework in efficient steps. Corey-Bakshi-Shibata reduction was employed to afford the enantioenriched intermediate for the total syntheses of the aforementioned alkaloids. The chirality was shown to completely transfer to the backbone using Johnson-Claisen rearrangement. The enantioselective total syntheses of (-)-kopsifoline D and (-)-beninine were accomplished for the first time. Our strategy opens up practical avenues for the total synthesis of structurally similar alkaloids.

Recommanded Product: 1,1,1-Triethoxyethane. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Zhou, YG; Wong, HNC; Peng, XS or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Ha, S; Lee, Y; Kwak, Y; Mishra, A; Yu, E; Ryou, B; Park, CM in NATURE PUBLISHING GROUP published article about BASIS-SET; PHOTOCYCLOADDITION; CATALYSIS; ENYNES; PALLADIUM; EFFICIENT; ELECTRON; CYCLOISOMERIZATION; FUNCTIONALIZATION; SENSITIZATION in [Ha, Sujin; Lee, Yeji; Kwak, Yoonna; Mishra, Akash; Yu, Eunsoo; Ryou, Bokyeong; Park, Cheol-Min] UNIST Ulsan Natl Inst Sci & Technol, Dept Chem, Ulsan 44919, South Korea in 2020.0, Cited 69.0. Product Details of 78-39-7. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7

UV-activated alkyne-alkene [2+2] cycloaddition has served as an important tool to access cyclobutenes. Although broadly adopted, the limitations with UV light as an energy source prompted us to explore an alternative method. Here we report alkyne-alkene [2+2] cycloaddition based on visible light photocatalysis allowing the synthesis of diverse cyclobutenes and 1,3-dienes via inter- and intramolecular reactions. Extensive mechanistic studies suggest that the localized spin densities at sp(2) carbons of alkenes account for the productive sensitization of alkenes despite their similar triplet levels of alkenes and alkynes. Moreover, the efficient formation of 1,3-dienes via tandem triplet activation of the resulting cyclobutenes is observed when intramolecular enyne cycloaddition is performed, which may serve as a complementary means to the Ru(II)-catalyzed enyne metathesis. In addition, the utility of the [2+2] cycloaddition has been demonstrated by several synthetic transformations including synthesis of various extended pi-systems.

About 1,1,1-Triethoxyethane, If you have any questions, you can contact Ha, S; Lee, Y; Kwak, Y; Mishra, A; Yu, E; Ryou, B; Park, CM or concate me.. Product Details of 78-39-7

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Diels-Alder route to norbornane derived vicinal phosphane/borane frustrated Lewis pairs for the metal-free catalytic hydrogenation of alpha, beta-unsaturated ketones WOS:000485104600004 published article about HETEROLYTIC DIHYDROGEN ACTIVATION; ELECTRONIC CONTROL; CHEMISTRY; REDUCTION; BIS(PENTAFLUOROPHENYL)BORANE; STEREOSELECTIVITY in [Woelke, Christian; Daniliuc, Constantin G.; Kehr, Gerald; Erker, Gerhard] Westfalische Wilhelms Univ Munster, Organ Chem Inst, Corrensstr 40, D-48149 Munster, Germany in 2019.0, Cited 56.0. Product Details of 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

The [4+2] cycloaddition reaction of the (dimesitylphosphino) cyclopentadienes 5a,b with N-phenyl-maleimide gave the norbornene derivative 9. Its reduction with LiAlH4 produced the N-phenyl-pyrrolidino-annulated system 10. Treatment with Piers’ borane gave the respective P/B FLP 12 as the major product, which cleaved dihydrogen under mild conditions to yield the phosphonium/hydrido borate product 14. Reaction of the phosphino-norbornene 10 with 2 M equiv. of Piers’ borane [HB(C6F5)(2)] followed by exposure to dihydrogen eventually gave the HB(C6F5)(2) adduct 15. This served as a catalyst for the hydrogenation of a series of chalcone derivatives. The system requires a pre-activation period before becoming active for the conjugated enone hydrogenation. (C) 2019 Elsevier B.V. All rights reserved.

Product Details of 94-41-7. About Chalcone, If you have any questions, you can contact Wolke, C; Daniliuc, CG; Kehr, G; Erker, G or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Oxovanadium(v)-catalyzed oxidative cross-coupling of enolates using O-2 as a terminal oxidant WOS:000574031500030 published article about CARBON BOND FORMATION; 1,4-DIKETONES; ENAMINES; SILANES; ETHERS; ACTIVATION; GENERATION; RADICALS in [Osafune, Yuma; Jin, Yuqing; Hirao, Toshikazu; Tobisu, Mamoru; Amaya, Toru] Osaka Univ, Grad Sch Engn, Suita, Osaka 5650871, Japan; [Hirao, Toshikazu] Osaka Univ, Inst Sci & Ind Res, Ibaraki, Osaka 5670047, Japan in 2020.0, Cited 37.0. Name: Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

The oxovanadium(v)-catalyzed oxidative cross-coupling of enolates using O(2)as a terminal oxidant is reported, where a boron enolate and a silyl enol ether were employed as enolates. The redox behavior of V(v/iv) in this reaction under O(2)was investigated by ESR and(51)V NMR experiments.

Name: Chalcone. About Chalcone, If you have any questions, you can contact Osafune, Y; Jin, YQ; Hirao, T; Tobisu, M; Amaya, T or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Vijayalakshmi, RV; Kuppan, R; Kumar, PP in ELSEVIER published article about LUMINESCENCE PROPERTIES; SNO2 NANOPARTICLES; GAS SENSOR; DOPED ZNO; EMISSION; VACANCY in [Vijayalakshmi, R. Vanathi] Queen Marys Coll, Dept Phys, Chennai 600004, Tamil Nadu, India; [Kuppan, Ravichandran] Univ Madras, Dept Nucl Phys, Guindy Campus, Chennai 600025, Tamil Nadu, India; [Kumar, P. Praveen] Presidency Coll, Dept Phys, Chennai 600005, Tamil Nadu, India in 2020.0, Cited 55.0. Formula: C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

This manuscript details the impact of stabilizing agents on the structural, optical properties of Ag@SnO2 core shell nanoparticles and its biological applications. Three different stabilizing agent viz. Poly Vinyl Pyrrolidone (PVP), zeroth generation triazolyl glycodendrimer and zeroth generation triazolyl chalcone dendrimer were used as stabilizers in the synthesis of Ag@SnO2 nanoparticles. The results were compared to study their effect on the structural and optical properties of the synthesized samples. The structural parameters of the samples were investigated by XRD analysis, FESEM and HRTEM images. The presence of SnO2 shell on the Ag core was also corroborated by XPS results. The XRD data was used for refining and characterizing the elements present in the sample by Reitveld method. The average crystallite size, dislocation density, lattice parameters (a, c), lattice strain of the samples were calculated using XRD measurements. Williamson – Hall (W-H) method and Size Strain Plot (SSP) method were used to calculate the lattice strain of the synthesized sample. The concentric rings of the SAED pattern and the lattice fringe images exhibited the interplanar d-spacing values and the results were compared with XRD measurements. The optical properties of the samples were investigated using UV-Vis spectra and the band gap energy were calculated using Tauc plot. The Photoluminescence (PL) studies of the Ag@SnO2 core – shell nanoparticles with the three stabilizing agents are also discussed in this work. The antibacterial and antifungal activities of the chalcone dendrimer stabilized Ag@SnO2 core – shell nanoparticles were tested against the pathogens Bacillus subtilis, Proteus mirabilis, Candida albicans and Aspergillus niger. (C) 2020 Elsevier B.V. All rights reserved.

Formula: C15H12O. About Chalcone, If you have any questions, you can contact Vijayalakshmi, RV; Kuppan, R; Kumar, PP or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article On the development of a nucleophilic methylthiolation methodology WOS:000550965600014 published article about ENANTIOSELECTIVE TOTAL-SYNTHESIS; S BOND FORMATION; NANOPARTICLES; SULFOXIDES; OXIDATION; SULFIDES; SULFONES in [Portinho de Puga Carvalho, Bernardo Basbaum; Pereira Amaral, Adriane Antonia; de Castro, Pedro Possa; Moreira Ferreira, Fernanda Cerqueira; Amarante, Giovanni Wilson] Univ Fed Juiz de Fora, Chem Dept, Campus Martelos, BR-36036900 Juiz De Fora, MG, Brazil; [Cautiero Horta, Bruno Araujo] Univ Fed Rio de Janeiro, CT Ctr Tecnol, Chem Inst, BR-21941909 Rio De Janeiro, Brazil in 2020, Cited 34. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. COA of Formula: C15H12O

Methylthiolation reactions are usually explored to access organosulfur compounds using methanethiol, an extremely flammable and toxic compound. Herein, methylthiomethyl esters were successfully applied as novel methylthiolation reagents in a low cost, transition-metal-free methodology. These reagents allowed the methylthiolation of a wide scope of chalcones, acyl ester derivatives and Morita-Baylis-Hillman acetates with good group tolerance, affording the methylthiolated products in moderate to excellent yields. The reaction mechanism was investigated through several control experiments, as well as by theoretical calculations employing Density Functional Theory. The results strongly support that a sulfurane and a sulfonium ylide appear as key intermediates and that a Pummerer type rearrangement is also crucial for the formation of this novel reagent. Furthermore, the methylthiolation mechanism is likely to proceed through the nucleophilic attack of the reagent, followed by an entropically favoured step involving the acetate attack to the positively charged species, then releasing the product.

COA of Formula: C15H12O. About Chalcone, If you have any questions, you can contact Carvalho, BBPD; Amaral, AAP; de Castro, PP; Ferreira, FCM; Horta, BAC; Amarante, GW or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recently I am researching about PHOSPHATE STARVATION RESPONSES; SYSTEM ARCHITECTURE; SUGAR; ARABIDOPSIS; BIOSYNTHESIS; PLANTS; ACID; EXPRESSION; GENES; IDENTIFICATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31872854]; Key Project of Liaoning Natural Science Foundation [20170540809]. Published in HINDAWI LTD in LONDON ,Authors: Yang, A; Kong, LJ; Wang, H; Yao, XD; Xie, FT; Wang, HY; Ao, X. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone. Name: Chalcone

Phosphorus (P) is one the least available essential plant macronutrients in soils that is a major constraint on plant growth. Soybean (Glycine max L.) production is often limited due to low P availability. The better management of P deficiency requires improvement of soybean’s P use efficiency. Sugars are implicated in P starvation responses, and a complete understanding of the role of sucrose together with P in coordinating P starvation responses is missing in soybean. This study explored global metabolomic changes in previously screened low-P-tolerant (Liaodou, L13) and low-P-sensitive (Tiefeng 3, T3) soybean genotypes by liquid chromatography coupled mass spectrometry. We also studied the root morphological response to sucrose application (1%) in P-starved soybean genotypes against normal P supply. Root morphology in L13 genotype has significantly improved P starvation responses as compared to the T3 genotype. Exogenous sucrose application greatly affected root length, root volume, and root surface area in L13 genotype while low-P-sensitive genotype, i.e., T3, only responded by increasing number of lateral roots. Root : shoot ratio increased after sucrose treatment regardless of P conditions, in both genotypes. T3 showed a relatively higher number of differentially accumulated metabolites between P-starved and normal P conditions as compared to L13 genotype. Common metabolites accumulated under the influence of sucrose were 5-O-methylembelin, D-glucuronic acid, and N-acetyl-L-phenylalanine. We have discussed the possible roles of the pathways associated with these metabolites. The differentially accumulated metabolites between both genotypes under the influence of sucrose are also discussed. These results are important to further explore the role of sucrose in the observed pathways. Especially, our results are relevant to formulate strategies for improving P efficiency of soybean genotypes with different P efficiencies.

About Chalcone, If you have any questions, you can contact Yang, A; Kong, LJ; Wang, H; Yao, XD; Xie, FT; Wang, HY; Ao, X or concate me.. Name: Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com