Month: November 2021

I found the field of Chemistry very interesting. Saw the article Potassium Carbonate Promoted Nucleophilic Addition of Alkenes with Phosphites published in 2020.0. SDS of cas: 94-41-7, Reprint Addresses Guo, SM (corresponding author), Nanchang Univ, Dept Chem, Nanchang 330031, Jiangxi, Peoples R China.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

A facile hydrophosphonylation of alkenes by phosphites promoted by potassium carbonate was developed. The reaction features include easy handling, environmental friendliness, and avoidance of the use of strong bases. A variety of alkenes are tolerated in this reaction, with moderate to excellent yields.

About Chalcone, If you have any questions, you can contact Huang, ZJ; Liu, W; Li, S; Yang, YT; Guo, SM; Cai, H or concate me.. SDS of cas: 94-41-7

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3-mediated apoptosis WOS:000456784800001 published article about GROWTH-FACTOR RECEPTOR; NATIONAL-CANCER-INSTITUTE; DRUG DISCOVERY; BREAST-CANCER; IN-VITRO; EXPRESSION; SURVIVAL; THERAPY; ASSAY in [Maher, Mai; Kassab, Asmaa E.; Zaher, Ashraf F.; Mahmoud, Zeinab] Cairo Univ, Dept Organ Pharmaceut Chem, Fac Pharm, Cairo 11562, Egypt in 2019.0, Cited 36.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7. Category: thiazolidines

A series of novel pyrazolo[3,4-d]pyrimidines was synthesised. Twelve synthesised compounds were evaluated for their anticancer activity against 60 human tumour cell lines by NCI (USA). Compound 7d proved prominent anticancer activity. It showed 1.6-fold more potent anti-proliferative activity against OVCAR-4 cell line with IC50 = 1.74 mu M. It also exhibited promising potent anticancer activity against ACHN cell line with IC50 value 5.53 mu M, representing 2.2-fold more potency than Erlotinib. Regarding NCI-H460 cell line, compound 7d (IC50 = 4.44 mu M) was 1.9-fold more potent than Erlotinib. It inhibited EGFR and ErbB2 kinases at sub-micromolar level (IC50 = 0.18 and 0.25 mu M, respectively). Dual inhibition of EGFR and ErbB2 caused induction of apoptosis which was confirmed by a significant increase in the level of active caspase-3 (11-fold). It showed accumulation of cells in pre-G1 phase and cell cycle arrest at G2/M phase.

Category: thiazolidines. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Maher, M; Kassab, AE; Zaher, AF; Mahmoud, Z or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Synthesis and properties of gem-dinitro energetic salts based on 1,2,4-oxadiazole with low impact sensitivity published in 2021.0. HPLC of Formula: C8H18O3, Reprint Addresses Chen, FX (corresponding author), Beijing Inst Technol, Sch Chem Sc Chem Engn, Liangxiang Campus,8 Liangxiang East Rd, Beijing 102488, Peoples R China.. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane

Eight energetic salts with a gem-dinitro group based on 1,2,4-oxadiazole were developed. All of the structures were confirmed by infrared (IR) spectroscopy, H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopy, and high-resolution mass spectrometry (HRMS), and single-crystal X-ray diffraction was used to determine the structures of the pivotal intermediate 3-(chlorodinitromethyl)-5-methyl-1,2,4-oxadiazole (3), the potassium salt (4) and the hydrazinium salt (7). All of them are insensitive to impact (>40 J) and have higher energy levels than trinitrotoluene (TNT).

HPLC of Formula: C8H18O3. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Lu, T; He, YN; Song, J; Hou, ZW; Yin, HQ; Fan, GJ; Chen, FX or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Formula: C15H12O. In 2020.0 ANGEW CHEM INT EDIT published article about AGGREGATION-INDUCED EMISSION; WHITE-LIGHT EMISSION; PIEZOCHROMIC LUMINESCENCE; MOLECULAR AGGREGATION; LIQUID-CRYSTALS; HIGH-EFFICIENCY; COLOR CHANGES; PHOTOLUMINESCENT; EMITTERS; ELECTROLUMINESCENCE in [Yang, Minlang; Park, In Seob; Yasuda, Takuma] Kyushu Univ, INAMORI Frontier Res Ctr IFRC, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan; [Yang, Minlang; Yasuda, Takuma] Kyushu Univ, Grad Sch Engn, Dept Appl Chem, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan; [Miyashita, Yasuhiro; Tanaka, Katsunori] Nippon Soda Co Ltd, Odawara Res Ctr, 345 Takada, Odawara, Kanagawa 2500280, Japan in 2020.0, Cited 82.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Herein, the universal design of high-efficiency stimuli-responsive luminous materials endowed with mechanochromic luminescence (MCL) and thermally activated delayed fluorescence (TADF) functions is reported. The origin of the unique stimuli-triggered TADF switching for a series of carbazole-isophthalonitrile-based donor-acceptor (D-A) luminogens is demonstrated based on systematic photophysical and X-ray analysis, coupled with theoretical calculations. It was revealed that a tiny alteration of the intramolecular D-A twisting in the excited-state structures governed by the solid morphologies is responsible for this dynamic TADF switching behavior. This concept is applicable to the fabrication of bicolor emissive organic light-emitting diodes using a single TADF emitter.

About Chalcone, If you have any questions, you can contact Yang, ML; Park, IS; Miyashita, Y; Tanaka, K; Yasuda, T or concate me.. Formula: C15H12O

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Asymmetric synthesis of highly functionalized furanones via direct Michael reactions mediated by a bulky primary amine WOS:000465285100029 published article about TETRONIC ACID-DERIVATIVES; ALPHA,BETA-UNSATURATED KETONES; CONJUGATE ADDITION; BETA-KETOCARBONYLS; ALKYLATION; 3(2H)-FURANONES; CONSTRUCTION; QUATERNARY; CATALYSIS; ALDEHYDES in [Huang, Huicai; Lu, Xue; Mao, Yukang] Guangzhou Univ Chinese Med, Res Ctr Chinese Herbal Resource Sci & Engn, Guangzhou 510006, Guangdong, Peoples R China; [Huang, Huicai; Lu, Xue; Mao, Yukang] Guangzhou Univ Chinese Med, Key Lab Chinese Med Resource Lingnan, Minist Educ, Guangzhou 510006, Guangdong, Peoples R China; [Ye, Jinxing] East China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China in 2019.0, Cited 61.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Category: thiazolidines

The asymmetric Michael reaction of 3(2H) furanones and alpha, beta-unsaturated ketones was investigated, with the employment of a bulky chiral primary amine. The protocol afforded a series of substituted furanone derivatives in a highly diastereo-(> 30 : 1 dr) and enantioselective (up to 93% ee) manner with generally good to excellent yields (up to 99%).

About Chalcone, If you have any questions, you can contact Huang, HC; Lu, X; Mao, YK; Ye, JX or concate me.. Category: thiazolidines

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article A highly efficient Hg(OTf)(2)-mediated Sakurai-Hosomi allylation of N-tert-butyloxycarbonylamino sulfones, aldehydes, fluoroalkyl ketones and alpha,beta-unsaturated enones using allyltrimethylsilane WOS:000501342100012 published article about CATALYTIC ENANTIOSELECTIVE ADDITION; ASYMMETRIC ALLYLATION; MEDIATED CYCLIZATION; CONJUGATE ALLYLATION; HOMOALLYLIC AMINES; AROMATIC-ALDEHYDES; CARBONYL-COMPOUNDS; GALLIUM CHLORIDE; ALLYLSILANES; MERCURY in [Gong, Yi; Zhou, Ying; Zhou, Jian] Guiyang Univ Chinese Med, Coll Pharm, Guiyang 550025, Guizhou, Peoples R China; [Cao, Zhong-Yan; Zhou, Feng; Zhou, Jian] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, 3663N Zhongshan Rd, Shanghai 200062, Peoples R China; [Cao, Zhong-Yan] Zhejiang Univ Technol, Coll Chem Engn, Chaowang Rd 18, Hangzhou 310014, Zhejiang, Peoples R China; [Shi, Ying-Bo] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610066, Sichuan, Peoples R China; [Zhou, Jian] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China in 2019.0, Cited 86.0. COA of Formula: C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

It is reported that cheap and easily available Hg(OTf)(2) can efficiently mediate the Sakurai-Hosomi reaction of N-tert-butyloxycarbonyl (Boc) amino sulfones, aldehydes, and alpha-fluoroalkyl ketones using allyltrimethylsilane, with the catalyst loading down to 0.5-5.0 mol%, enabling the facile access to synthetically valuable homoallylic alcohols or amines, respectively. A chemoselective 1,4-allylation of alpha,beta-unsaturated enones is also achieved under the catalysis of 5.0 mol% Hg(OTf)(2). In most cases, Hg(OTf)(2) exhibited intriguing properties superior to those of commonly used metal Lewis acids for such reactions, suggesting that mercury catalysis is worthwhile to explore.

About Chalcone, If you have any questions, you can contact Gong, Y; Cao, ZY; Shi, YB; Zhou, F; Zhou, Y; Zhou, J or concate me.. COA of Formula: C15H12O

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Al-Azmi, A; Mahmoud, H in AMER CHEMICAL SOC published article about TRIAZOLE; COMPLEXES; PYRAZOLE in [Al-Azmi, Amal] Kuwait Univ, Chem Dept, Kuwait 13060, Kuwait; [Mahmoud, Huda] Kuwait Univ, Dept Biol Sci, Kuwait 13060, Kuwait in 2020.0, Cited 32.0. Name: 1,1,1-Triethoxyethane. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7

A group of novel 1,4-bis(3,5-dialkyl-4H-1,2,4-triazol-4-yl)bencene and 5-aryltriaz- 1-en-1-yl-1-phenyl-1H-pyrazole-4-carbonitrile derivatives have been successfully synthesized and characterized by spectroscopic analyses. The triazenes were obtained in moderate yield by a coupling reaction between 5-aminopyrazol-4-carbonitrile and aryl diazonium chlorides, and their structures were confirmed by detecting the CN functional group in both IR and C-13 NMR spectra. Conversely, the novel 1,4-bis(3,5-dialkyl-4H-1,2,4-triazol-4-yl)benzene derivatives were obtained using a previously unreported and facile pathway starting with p-phenylenediamine with selected triethyl orthoalkylates and then hydrazine monohydrate, followed by refluxing in triethyl orthoalkylates. The structure of the methyl derivative was confirmed by X-ray analysis. The synthesized compounds were tested and evaluated as antimicrobial agents.

Name: 1,1,1-Triethoxyethane. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Al-Azmi, A; Mahmoud, H or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Computed Properties of C8H18O3. In 2020.0 ACS CATAL published article about CONJUGATE ADDITION; UNACTIVATED ALKENES; CARBONYL-COMPOUNDS; ALPHA-ARYLATION; ARYL HALIDES; ENONES; PD; IODIDES; OLEFINS; HYDROCARBOFUNCTIONALIZATION in [Guo, Tao; Ding, Yalan; Zhou, Lili; Loh, Teck-Peng; Wu, Xiaojin] Nanjing Tech Univ, Sch Chem & Mol Engn, Inst Adv Synth, Nanjing 211816, Peoples R China; [Wu, Xiaojin] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637616, Singapore; [Xu, Haiyan] Jiangsu Univ Sci & Technol, Sch Environm & Chem Engn, Zhenjiang 212003, Jiangsu, Peoples R China in 2020.0, Cited 71.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7.

A general intermolecular anti-Michael reductive Heck reaction of alpha,beta-unsaturated esters with organobromides has been developed. Most topical classes of aryl, heteroaryl, and vinyl bromides were found to efficiently react with a variety of internal conjugated alkenes. This protocol set up a platform toward diverse alpha-arylated 1,6-dicarbonyl frameworks found in natural products and drugs, which are still highly challenging targets in traditional alpha-arylation protocols because of competitive selectivity of enolation. A removable directing group, gram-scale reaction, and modification of complex molecules have additionally demonstrated that the anti-Michael reductive Heck reaction is a powerful complementary strategy to the classical alpha-arylation approaches. Preliminary mechanistic studies are consistent with our proposed mechanistic design.

Computed Properties of C8H18O3. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Guo, T; Ding, YL; Zhou, LL; Xu, HY; Loh, TP; Wu, XJ or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Computed Properties of C15H12O. Sanad, SMH; Mekky, AEM in [Sanad, Sherif M. H.; Mekky, Ahmed E. M.] Cairo Univ, Fac Sci, Chem Dept, Giza 12613, Egypt published Novel nicotinonitrile-coumarin hybrids as potential acetylcholinesterase inhibitors: design, synthesis, in vitro and in silico studies in 2021.0, Cited 59.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Alzheimer’s disease is a degenerative brain condition that is the leading cause of dementia affecting millions of people around the world. Therapeutic development has focused on the problem of the loss of basal forebrain cholinergic function, as it is the only evidence responsible for brain neurodegeneration in patients with Alzheimer’s disease. Several attempts to improve cholinergic neurotransmission have been investigated by minimizing synaptic degradation of acetylcholine using acetylcholinesterase inhibitors. In the current study, we explore the designing of a new series of nicotinonitrile-coumarin hybrids as potential acetylcholinesterase inhibitors. The new hybrids were prepared utilizing pyridine-2(1H)-thiones as starting precursors. The in vitro acetylcholinesterase (AChE) inhibitory activities were examined for the new nicotinonitrile-coumarin hybrid molecules, when compared with donepezil as a standard drug with IC(50)of 14 nM. Coumarin derivative, linked to 6-(4-nitrophenyl)-4-phenylnicotinonitrile, showed more effective inhibitory activity than the reference donepezil with IC(50)of 13 nM. The free radical-scavenging capabilities against DPPH of the new hybrid derivatives were screened. Additionally, their in vitro cytotoxic activities have been tested against various eukaryotic cells. Furthermore, docking study showed excellent interaction between nicotinonitrile-coumarin hybrids and AChE. [GRAPHICS] .

Computed Properties of C15H12O. About Chalcone, If you have any questions, you can contact Sanad, SMH; Mekky, AEM or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Computed Properties of C8H18O3. Recently I am researching about BIOLOGICAL EVALUATION; DERIVATIVES, Saw an article supported by the State Committee for Science, Ministry for Edication and Science, Republic of Armenia [18T-1D066]. Published in MAIK NAUKA/INTERPERIODICA/SPRINGER in NEW YORK ,Authors: Paronikyan, EG; Dashyan, SS; Mamyan, SS. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane

A method for the synthesis of derivatives of 8-hydrazino 6-thioxopyrano[3,4-c]pyridine has been developed. Derivatives of 8-hydrazino-6-(methylsulfanyl)pyrano[3,4-c]pyridines and 5-(or 3)-(alkylsulfanyl)pyrano[3,4-c][1,2,4]triazolo[4,3-a]pyridines have been synthesized. The thione-thiol tautomerism of 5-thioxopyrano[3,4-c][1,2,4]triazolo[4,3-a]pyridine has been studied. In a basic medium, the equilibrium shifts toward the thiol form, which has allowed synthesis ofS-alkyl-substituted triazolo[4,3-a]pyridines.

About 1,1,1-Triethoxyethane, If you have any questions, you can contact Paronikyan, EG; Dashyan, SS; Mamyan, SS or concate me.. Computed Properties of C8H18O3

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com