Month: December 2021

Authors Zeitoun, H; Khan, Z; Banerjee, K; Salameh, D; Lteif, R in MDPI published article about RESPONSE-SURFACE METHODOLOGY; TYROSINASE INHIBITORS; PHENOLIC-COMPOUNDS; ANTIOXIDANTS; LEAVES; FOOD in [Zeitoun, Hussein; Salameh, Dominique; Lteif, Roger] Univ St Joseph, Fac Sci, Ctr Anal & Rech, Unite Technol & Valorisat Alimentaire, Campus Sci & Technol,POB 11-514, Beirut 11072050, Lebanon; [Khan, Zareen; Banerjee, Kaushik] ICAR Natl Res Ctr Grapes, Natl Reference Lab, Pune 412307, Maharashtra, India in 2020.0, Cited 55.0. Safety of Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Tyrosinase is an important component of the enzyme polyphenol oxidase, which upon contact with the phenolic substrates forms the pigment melanin and induces undesirable food browning. The phenolic and triterpenoid compounds that naturally occur in plants are well known as tyrosinase inhibitors. Combretum micranthum (CM) leaves, Euphorbia hirta (EH) plant, and Anacardium occidentale (AO) fruits are traditionally known to have potential anti-tyrosinase activities. The aim of this study was to optimize the ultrasound-assisted extraction of secondary metabolites from these matrices, and to evaluate in tubo the antityrosinase activity of these extracts. Efforts were also taken to profile the secondary metabolites, mainly the phenolic and triterpenoid compounds, in order to understand their probable association with tyrosinase inhibition. The optimal ultrasound-assisted extraction conditions for simultaneous extraction of phenolic, and triterpenoid compounds were determined. The aqueous fraction of these extracts showed significant antityrosinase activity, with the CM leaves exhibiting the strongest inhibitory effect (IC50 of 0.58 g.L-1). The predominant metabolic compounds from these natural extracts were putatively identified by using a high-resolution quadrupole-time of flight (QToF) LC-MS instrument. The high-resolution accurate mass-based screening resulted in identification of 88 predominant metabolites, which included dihydrodaidzein-7-O-glucuronide, micromeric acid, syringic acid, morin, quercetin-3-O-(6 ”-malonyl-glucoside), 4-hydroxycoumarin, dihydrocaffeic acid-3-O-glucuronide, to name some, with less than 5 ppm of mass error.

Safety of Chalcone. Welcome to talk about 94-41-7, If you have any questions, you can contact Zeitoun, H; Khan, Z; Banerjee, K; Salameh, D; Lteif, R or send Email.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Formula: C15H12O. In 2020.0 J ETHNOPHARMACOL published article about CHINESE HERBAL MEDICINE; URSODEOXYCHOLIC ACID; ALLERGIC RHINITIS; LIVER; NAPHTHYLISOTHIOCYANATE; ACUPUNCTURE; EFFICACY in [Zhang, Zhiyong; Miao, Yiru; Xu, Min; Cheng, Wenming; Yang, Chuanyan; She, Xiangjian; Geng, Qianqian; Zhang, Qunlin] Anhui Med Univ, Sch Pharm, Hefei 230032, Anhui, Peoples R China in 2020.0, Cited 54.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Ethnopharmacological relevance: TianJiu (TJ) therapy, one type of cold moxibustion, applies to specific acupuncture points with herbal patches of hot nature, providing a constant irritant to the skin until the presence of hyperemia and blistering. Traditional and clinical reports suggest that TJ is an effective therapy for the treatment of jaundice with fresh Ranunculus sceleratus L. (RS), in which protoanemonin is one of the main irritant constituents. However, the therapeutic effect of TJ treatment with fresh RS against intrahepatic cholestasis has not been studied in animal experiments. Aim of the study: Present study was undertaken to investigate the effect of TJ treatment with fresh RS against intrahepatic cholestasis in rats and provide an experimental basis for the underlying mechanism of TJ therapy. Materials and methods: Male intrahepatic cholestatic Sprague-Dawley rats induced by 2% alpha-naphthylisothiocyanate (ANIT, 80 mg/kg B.W.) were treated by TJ therapy with fresh RS. The levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), direct bilirubin (DBIL), total bilirubin (TBIL), total bile acid (TBA), hepatic malondialdehyde (MDA) and nitric monoxide (NO), as well as hepatic body ratio, bile flow and hepatic histopathological assay were measured and evaluated to investigate the therapeutic effect of TJ treatment with fresh RS. Phytochemical analysis of fresh and dried RS was performed by gas chromatography-mass spectrometer (GC-MS). Results: After TJ treatment with fresh RS, the abnormally elevated levels of serum AST, ALT, ALP, DBIL, TBIL and TBA, as well as hepatic MDA and NO at 108 h were reduced significantly (versus model group, P < 0.01). The hepatic body ratio, bile flow and hepatic pathological change of cholestatic rats at 108 h in TJ group were restored when compared with those of model group. Thirty-one compounds including lactones, flavonoids and phenolic acids were identified and determined by GC-MS analysis. The content of protoanemonin in fresh RS (9.49%) was about 25-fold higher than that in dried RS (0.38%). Conclusions: TJ treatment with fresh RS exhibited good therapeutic effect on ANIT-induced intrahepatic cholestasis in rats, which may be due to the attenuated oxidative stress in the liver tissue. It is rational for the ancients to choose fresh RS as TJ herbal patches because of its abundant protoanemonin with the character of irritant. The qualitative and quantitative results of GC-MS analysis provided the chemical basis of TJ therapy with fresh RS, which can be regarded as a simple and efficient method for the treatment of cholestasis hepatitis. Formula: C15H12O. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Quality Control of 1,1,1-Triethoxyethane. In 2020.0 ARCH PHARM published article about PLASMA-MEMBRANE; IN-VITRO; ANTICANCER; PHOSPHATIDYLSERINE; CYCLE; DAMAGE; DNA in [Gaonkar, Supreet; Nadaf, AfraQuasar A.; Najare, Mahesh S.; Mantur, Shivaraj; Garbhagudi, Manjunatha; Khazi, Imtiyaz Ahmed M.] Karnatak Univ, Dept Studies Chem, Dharwad 580003, Karnataka, India; [Savanur, Mohammed Azharuddin] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India; [Mulla, Sikandar I.] REVA Univ, Sch Appl Sci, Dept Biochem, Bangalore, Karnataka, India in 2020.0, Cited 36.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7.

The paucity of effective anticancer drugs for successful treatment is a major concern, indicating the strong need for novel therapeutic compounds. In the quest of new molecules, the present study aimed to explore the potential of pyrazolo[3,4-d]pyrimidine derivatives as antiproliferative agents. In vitro anticancer screening of selected compounds was done by the National Cancer Institute’s Developmental Therapeutics Programme against a panel of 60 cancer cell lines. The lead compound PP-31d considerably inhibited the growth of cancer cells, such as NCI-H460 (non-small-cell lung cancer), OVCAR-4 (ovarian cancer), 786-0 (renal cancer), A549 (non-small-cell lung cancer), and ACHN (renal cancer), showing strong anticancer potential, among other derivatives. Kinetic studies of PP-31d on NCI-H460 cells revealed a dose-dependent effect with an IC50 of 2 mu M. The observed inhibition by PP-31d is attributed to the generation of reactive oxygen species and the subsequent induction of cellular apoptosis, as evidenced by the increase in the hypodiploid (subG1) population, the early apoptotic cell population, and caspase-3/7 activity, the loss of the mitochondrial membrane potential, and the degradation of nuclear DNA. Collectively, our results demonstrated that pyrazolo[3,4-d]pyrimidine derivatives inhibit cancer cell proliferation by inducing apoptosis and, thus, have the potential to be further explored for anticancer properties.

Welcome to talk about 78-39-7, If you have any questions, you can contact Gaonkar, S; Savanur, MA; Nadaf, AA; Najare, MS; Mantur, S; Garbhagudi, M; Mulla, SI; Khazi, IAM or send Email.. Quality Control of 1,1,1-Triethoxyethane

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Rusinov, VL; Drokin, RA; Tiufiakov, DV; Voinkov, EK; Ulomsky, EN in ELSEVIER published article about NITRO ALCOHOLS in [Rusinov, Vladimir L.; Drokin, Roman A.; Tiufiakov, Dmitrii V.; Voinkov, Egor K.; Ulomsky, Evgeny N.] Ural Fed Univ, Inst Chem Engn, Ekaterinburg 620002, Russia; [Rusinov, Vladimir L.; Ulomsky, Evgeny N.] Russian Acad Sci, I Ya Postovsky Inst Organ Synth, Ural Branch, Ekaterinburg 620108, Russia in 2020.0, Cited 29.0. Recommanded Product: 1,1,1-Triethoxyethane. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7

A new safe synthesis of a-nitro ketone salts via alkaline hydrolysis of 2-morpholino-1-nitroalkenes has been developed. The salts were introduced into the reactions of diazotization and heterocyclization. Crystal structures of new 2-morpholino-1-nitrobut-1-ene and 6-ethyl-5-nitro-4phe-nyl-3,4-dihydropyrimidin-2-one have been determined.

Recommanded Product: 1,1,1-Triethoxyethane. Welcome to talk about 78-39-7, If you have any questions, you can contact Rusinov, VL; Drokin, RA; Tiufiakov, DV; Voinkov, EK; Ulomsky, EN or send Email.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Intercepted dehomologation of aldoses by N-heterocyclic carbene catalysis – a novel transformation in carbohydrate chemistry published in 2019.0. COA of Formula: C15H12O, Reprint Addresses Stanetty, C (corresponding author), TU Wien, Inst Appl Synthet Chem, A-1060 Vienna, Austria.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

The development of an N-heterocyclic carbene (NHC) catalysed intercepted dehomologation of aldoses is reported. The unique selectivity of NHCs for aldehydes is exploited in the complex context of reducing sugars. Examples of strong substrate governance for either intercepted dehomologation or a subsequent redox-lactonisation were identified and mechanistically understood. More importantly, it was shown that catalyst design allowed the tuning of the selectivity of the reaction with structurally unbiased starting materials towards either of the two scenarios.

Welcome to talk about 94-41-7, If you have any questions, you can contact Draskovits, M; Kalaus, H; Stanetty, C; Mihovilovic, MD or send Email.. COA of Formula: C15H12O

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article In vitroantiproliferative activity of glabridin derivatives and theirin silicotarget identification WOS:000539722400011 published article about INHIBITS MIGRATION; ISOFLAVAN GLABRIDIN; LICORICE ROOT; INVASION; ANGIOGENESIS; CELLS in [Kapkoti, Deepak Singh; Bhakuni, Rajendra Singh] CSIR Cent Inst Med & Aromat Plants, Med Chem Dept, Lucknow, Uttar Pradesh, India; [Singh, Shilpi; Luqman, Suaib] CSIR Cent Inst Med & Aromat Plants, Mol Bioprospect Dept, Lucknow, Uttar Pradesh, India; [Alam, Sarfaraz; Khan, Feroz] CSIR Cent Inst Med & Aromat Plants, Metab & Struct Biol Dept, Lucknow, Uttar Pradesh, India in 2020.0, Cited 19.0. Quality Control of Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Novel Mannich base derivatives of glabridin were synthesized and their antiproliferative activity were performed along with our previously reported glabridin-chalcone hybrids molecules (GCHMs) against various human cell lines MDA-MB-231 (breast adenocarcinoma), HEK-293 (embryonic kidney cell line), K562 (leukemia), MCF-7 (breast adenocarcinoma), HeLa (cervix adenocarcinoma), HepG2 (hepatocellular carcinoma) and WRL-68 (hepatic carcinoma). The result showed that the glabridin significantly reduced cell proliferation with IC(50)ranges from 3.67 to 58.30 mu M against all the tested cell lines. The remarkable reduction in antiproliferative activity 2′,4′-dimethoxyglabridin and GCHMs compounds with phenolic OH groups protected by methoxy (OCH3) groups suggested that the free OH groups are essential factor for the antiproliferative activity of glabridin and its derivatives. The Mannich base derivatives of glabridin showed moderate activity IC50(2.20->95.78 mu M). Furthermore,in silicotarget identification analysis revealed that AKT1, DECR1 and NOS1 are the potential targets for glabridin and their derivatives.

Welcome to talk about 94-41-7, If you have any questions, you can contact Kapkoti, DS; Singh, S; Alam, S; Khan, F; Luqman, S; Bhakuni, RS or send Email.. Quality Control of Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recommanded Product: 1,1,1-Triethoxyethane. In 2020.0 J ORG CHEM published article about ENANTIOSELECTIVE TOTAL SYNTHESES; MITSUNOBU REACTION; AKUAMMILINE ALKALOIDS; INDOLE ALKALOIDS; FORMAL SYNTHESIS; (+)-ASPIDOSPERMIDINE; REARRANGEMENT in [Zhou, Yi-Guo; Wong, Henry N. C.; Peng, Xiao-Shui] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong 100051, Peoples R China; [Zhou, Yi-Guo; Wong, Henry N. C.; Peng, Xiao-Shui] Chinese Univ Hong Kong, State Key Lab Synthet Chem, Shatin, Hong Kong 100051, Peoples R China; [Wong, Henry N. C.; Peng, Xiao-Shui] Chinese Univ Hong Kong Shenzhen, Sch Sci & Engn, Shenzhen 518172, Peoples R China; [Wong, Henry N. C.; Peng, Xiao-Shui] Chinese Univ Hong Kong, Shenzhen Municipal Key Lab Chem Synth Med Organ M, Shenzhen Res Inst, Shenzhen 518507, Peoples R China in 2020.0, Cited 33.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7.

The total syntheses of Aspidosperma and Kopsia alkaloids (-)-deoxoapodine, (-)-kopsifoline D, and (-)-beninine are described through a domino deprotection-Michael addition-nucleophilic substitution protocol to assemble the core framework in efficient steps. Corey-Bakshi-Shibata reduction was employed to afford the enantioenriched intermediate for the total syntheses of the aforementioned alkaloids. The chirality was shown to completely transfer to the backbone using Johnson-Claisen rearrangement. The enantioselective total syntheses of (-)-kopsifoline D and (-)-beninine were accomplished for the first time. Our strategy opens up practical avenues for the total synthesis of structurally similar alkaloids.

Welcome to talk about 78-39-7, If you have any questions, you can contact Zhou, YG; Wong, HNC; Peng, XS or send Email.. Recommanded Product: 1,1,1-Triethoxyethane

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Toth, S; Szepesi, A; Tran-Nguyen, VK; Sarkadi, B; Nemet, K; Falson, P; Di Pietro, A; Szakacs, G; Boumendjel, A in MDPI published article about COLLATERAL SENSITIVITY; CANCER; THIOSEMICARBAZONES; AURONES in [Toth, Szilard; Szepesi, Aron; Sarkadi, Balazs; Nemet, Katalin; Szakacs, Gergely] Hungarian Acad Sci, Res Ctr Nat Sci, Inst Enzymol, H-1117 Budapest, Hungary; [Tran-Nguyen, Viet-Khoa; Boumendjel, Ahcene] Univ Grenoble Alpes, Dept Pharmacochim Mol, UMR 5063, F-38041 Grenoble, France; [Nemet, Katalin] Creat Cell Ltd, H-1119 Budapest, Hungary; [Falson, Pierre; Di Pietro, Attilio] Univ Lyon, CNRS UMR 5086, Mol Microbiol & Struct Biochem Lab, Drug Resistance & Membrane Prot Grp,IBCP, 7 Passage Vercors, F-69367 Lyon, France; [Szakacs, Gergely] Med Univ Vienna, Inst Canc Res, Borschkegasse 8A, A-1090 Vienna, Austria in 2020, Cited 30. Application In Synthesis of Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

The resistance of tumors against anticancer drugs is a major impediment for chemotherapy. Tumors often develop multidrug resistance as a result of the cellular efflux of chemotherapeutic agents by ABC transporters such as P-glycoprotein (ABCB1/P-gp), Multidrug Resistance Protein 1 (ABCC1/MRP1), or Breast Cancer Resistance Protein (ABCG2/BCRP). By screening a chemolibrary comprising 140 compounds, we identified a set of naturally occurring aurones inducing higher cytotoxicity against P-gp-overexpressing multidrug-resistant (MDR) cells versus sensitive (parental, non-P-gp-overexpressing) cells. Follow-up studies conducted with the P-gp inhibitor tariquidar indicated that the MDR-selective toxicity of azaaurones is not mediated by P-gp. Azaaurone analogs possessing pronounced effects were then designed and synthesized. The knowledge gained from structure-activity relationships will pave the way for the design of a new class of anticancer drugs selectively targeting multidrug-resistant cancer cells.

Welcome to talk about 94-41-7, If you have any questions, you can contact Toth, S; Szepesi, A; Tran-Nguyen, VK; Sarkadi, B; Nemet, K; Falson, P; Di Pietro, A; Szakacs, G; Boumendjel, A or send Email.. Application In Synthesis of Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Category: thiazolidines. In 2019.0 J MOL STRUCT published article about BIOLOGICAL EVALUATION; GA-MLR; ANTICANCER; AGENTS; DOCKING; ANALOGS; DESIGN; MODEL; QSPR in [Ahmadi, Shahin] Islamic Azad Univ, Dept Chem, Kermanshah Branch, Kermanshah, Iran; [Mardinia, Fariba; Balali, Ebrahim] Islamic Azad Univ, Dept Chem, Fac Pharmaceut Chem, Tehran Med Sci, Tehran, Iran; [Azimi, Neda] Islamic Azad Univ, Dept Chem Engn, Kermanshah Branch, Kermanshah, Iran; [Qomi, Mahnaz] Islamic Azad Univ, Act Pharmaceut Ingredients Res APIRC, Tehran Med Sci, Tehran, Iran in 2019.0, Cited 43.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

The anticancer activity of chalcones and their analogs is the most important biological activity of them among their broad spectrum of their biological activity. In this investigation, we performed quantitative structure-activity relationship (QSAR) modeling of the anticancer activity of 134 chalcones and their analogs against MCF-7 human breast cancer cell lines using Monte Carlo method. QSAR models were calculated by CORAL software and optimal descriptors were calculated with SMILES and hydrogen suppressed molecular graph (HSG). The total dataset split into training, invisible training, calibration, and validation set randomly. Analysis of three probes of the Monte Carlo optimization with three random splits was done. Results from three random splits displayed robust, very simple, predictable, and reliable models for training, invisible training, calibration, and validation set with the correlation coefficient (R-2) of 0.8142-0.8244, 0.8244-0.8699, 0.8125-0.8627 and 0.8290-0.8686 respectively. As a result, the obtained models help to identify the hybrid descriptors for the increase and the decrease of anticancer activity of chalcones against MCF-7 human breast cancer cell lines. This simple QSAR model can be used for prediction of log IC50 of numerous chalcone derivatives against breast cancer cell. (C) 2019 Elsevier B.V. All rights reserved.

Category: thiazolidines. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recommanded Product: Chalcone. In 2020.0 NANOMATERIALS-BASEL published article about FACILE SYNTHESIS; BI2MOO6; COMPOSITE; CATALYST in [Li, Haiying; Yu, Xiujuan; Hao, Xueli; Zhang, Zhiying; Wang, Yan; Li, Jingyi] Inner Mongolia Univ, Coll Chem & Chem Engn, Hohhot 010021, Peoples R China; [Yu, Xiujuan] Hebei North Univ, Hebei Key Lab Neuropharmacol, Zhangjiakou 075000, Peoples R China in 2020.0, Cited 32.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Bi(NO3)(3)center dot 5H(2)O and (NH4)(6)Mo7O24 center dot 4H(2)O were used as precursors to synthesize flaky gamma-Bi2MoO6 samples by a hydrothermal method, and Pt/gamma-Bi2MoO6 samples with different mass fractions were prepared by an NaBH4 reduction method. Alpha alkylation of benzyl alcohol and acetophenone with photocatalysts under visible light irradiation was performed, and the activity of 4 wt % Pt/gamma-Bi2MoO6 (gamma-Bi2MoO6 was prepared by a nitric acid method, pH = 9, and reaction temperature 180 degrees C) was the best. The photocatalytic reaction conditions were optimized by changing various kinds of variables, such as the type of catalyst, solvent, and base, and the amount of base, catalyst, and reactant. The optimal conditions for the organic reaction were 75 mg 4 wt % Pt/gamma-Bi2MoO6, 6 mL n-heptane, 1.2 mmol NaOH, 1 mmol acetophenone, and 3 mmol benzyl alcohol. Under the optimal reaction conditions, the effects of different light wavelengths and light intensities on the reaction were measured, and the cycling ability of the photocatalyst was tested. After five cycles, the photochemical properties of the catalyst were relatively stable. Finally, the active substances were identified (such as electrons (e(-), holes (h(+)), hydroxyl radicals (center dot OH), and superoxide radicals (center dot O-2(-)).

Welcome to talk about 94-41-7, If you have any questions, you can contact Li, HY; Yu, XJ; Hao, XL; Zhang, ZY; Wang, Y; Li, JY or send Email.. Recommanded Product: Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com