2682-49-7, Name is Thiazolidin-2-one, belongs to thiazolidine compound, is a common compound. Computed Properties of C3H5NOSIn an article, once mentioned the new application about 2682-49-7.
Vanillin-related N-acylhydrazones: Synthesis, antischistosomal properties and target fishing studies
Background: Schistosomiasis is a neglected disease, which affects millions of people in developing countries. Its treatment relies on a single therapeutic alternative, the praziquantel. This situation may lead to drug resistance which, in turn, made urgent the need for new antischistosomal agents. N-acylhydrazones are usually explored as good antimicrobial agents, but the vanillin-related N-acylhydrazones have never been tested by their antiparasitic potential. Objective: Herein, we report the synthesis of seven analogues, three of them unpublished, their biological investigation against Schistosoma mansoni and Target Fishing studies. Methods: The compounds were synthesized following classical synthetical approaches. The anthelmintic potential was assessed as well as their cytotoxicity profile. Confocal laser scanning microscopy and target fishing study were performed to better understand the observed antischistosomal activity. Results: Compound GPQF-407 exhibited good antischistosomal activity (47.91 muM) with suitable selectivity index (4.14). Confocal laser scanning microscopy revealed that it triggered severe tegumental destruction and tubercle disintegration. Target fishing studies pointed out some probable targets, such as the serine-threonine kinases, dihydroorotate dehydrogenases and carbonic anhydrase II. Conclusion: The GPQF-407 was revealed to be a promising antischistosomal agent which, besides presenting the N-acylhydrazone privileged scaffold, also could be easily synthesized on large scales from commercially available materials.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Computed Properties of C3H5NOS, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about Computed Properties of C3H5NOS
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Quinuclidine – Wikipedia,
Quinuclidine | C7H424N | ChemSpider