With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5908-62-3,1,1-Dioxo-isothiazolidine,as a common compound, the synthetic route is as follows.,5908-62-3
To a solution of tert-butyl (3S)-3- [[4- [2- [(5 -iodo-2-methyl- 1 -naphthyl)oxy]-3 – pyridyl]pyrimidin-2-yl]amino]piperidine-1-carboxylate (110 mg, 0.17 mmol) in CH3CN (2 mL) was added 1,3-propanesultam (209.1 mg, 1.73 mmol), copper iodide (1.6 mg, 0.01 mmol), N,N?-dimethyl-1,2-ethanediamine (7.6 mg, 0.09 mmol) and potassium carbonate (47.8 mg, 0.34 mmol). The mixture was purged with N2 and stirred at 80 C for 88 h. After cooling down, the mixture was filtered, concentrated, dissolved in ethyl acetate (60 mL) and washed with H20 (50 mL x 2). The organic phase was dried over anhydrous sodium sulfate and concentrated and the residue was purified by Prep-TLC (50% ethyl acetate in petroleum ether,Rf= 0.1) to yield 55 mg (51%) of the title compound as a brown oil. LCMS (ESI) [M+H]=631.0.
5908-62-3 1,1-Dioxo-isothiazolidine 642157, athiazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; GENENTECH, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; BRAUN, Marie-Gabrielle; GIBBONS, Paul; LEE, Wendy; LY, Cuong; RUDOLPH, Joachim; SCHWARZ, Jacob; ASHKENAZI, Avi; FU, Leo; LAI, Tommy; WANG, Fei; BEVERIDGE, Ramsay; ZHAO, Liang; (652 pag.)WO2018/166528; (2018); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com