New Advances in Chemical Research, May 2021. Quality Control of 1,1-Dioxo-isothiazolidine, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. In a document type is Article, and a compound is mentioned, 5908-62-3, 1,1-Dioxo-isothiazolidine, introducing its new discovery.
A series of novel HIV integrase inhibitors active against rategravir resistant strains are reported. Initial SAR studies revealed that activities against wild-type virus were successfully maintained at single digit nanomolar level with a wide range of substitutions. However, inclusion of nitrogen-based cyclic substitutions was crucial for achieving potency against mutant viruses. Several compounds with excellent activities against wild-type virus as well as against the viruses with the mutations Q148H/G140S or N155H/E92Q were reported.
Quality Control of 1,1-Dioxo-isothiazolidine, Interested yet? Read on for other articles about Quality Control of 1,1-Dioxo-isothiazolidine!
Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H578N | ChemSpider