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Some new beta-lactams bearing biologically important morpholine ring have been synthesized by acylation of amino beta-lactams in the presence of morpholine-4-carbonyl chloride. These novel beta-lactams were prepared under mild reaction conditions without any solvent in short reaction times. Their biological activities have been examined against microbial agents such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and fungi such as Candida albicans (C. albicans) and Candida glabrata (C. glabrata). They have been also tested against Plasmodium falciparum K14 resistant strain and showed moderate to good IC50 values.
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Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H327N | ChemSpider