Recently I am researching about FLUORESCENCE CHEMOSENSORS; DIRECT AMIDATION; FACILE SYNTHESIS; RAPID SYNTHESIS; DERIVATIVES; INHIBITORS; MCI-186; ACIDS; DISCOVERY; ISCHEMIA, Saw an article supported by the UGC-IndiaUniversity Grants Commission, India; CUG-India. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Lakshmi, SR; Singh, V; Chowhan, LR. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone. Quality Control of Chalcone
Tandem conjugate addition, decarboxylation and esterification/amidation of coumarin 3-carboxylic acid derivatives with pyrazolones have been developed. The reactions were performed with coumarin 3-carboxylic acid/esters and pyrazolone in alcohol as a solvent to afford the corresponding pyrazolyl 2-hydroxy phenylpropionate derivatives. Amines and green solvents were employed for amidation in the addition reaction. The methodology has advantages such as excellent yields, a broad substrate scope, catalyst-free, easy purification by simple filtration without any workup, mild conditions and does not require any organic solvents, ligands, base or any additives. This is a green and general synthetic protocol, which could be applicable for the synthesis of substituted pyrazolyl phenyl propionate/amide derivatives. This approach demonstrates the importance of the coumarin 3-carboxylic acid/ester core structure for Michael addition.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com