The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.Quality Control of Thiazolidin-2-one, Name is Thiazolidin-2-one, molecular formula is C3H5NOS, Quality Control of Thiazolidin-2-one. In a Review, authors is Wei, Jinlian，once mentioned of Quality Control of Thiazolidin-2-one
Recent advances in the discovery of hif- 1alpha-p300/cbp inhibitors as anticancer agents
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric (containing alpha and beta subunits) transcription factor, is involved in hypoxia response pathway that regulates the expression of many tumor-related genes. The stabilized HIF-1 heterodimer couples to the general co-activators p300/CBP (CREB binding protein), forming an active transcription factor to initiate hypoxic responses. Inhibiting the transcription factor-coactivator HIF-1alpha-p300/CBP interaction represents an attractive approach for blocking hypoxia pathway in tumors. Recently, diverse HIF-1alpha-p300/CBP inhibitors have been designed and their anti-tumor activities have been evaluated. The developments of inhibitors of HIF-1alpha- p300/CBP are discussed in this review. An outline of structures and biological activities of these inhibitors can be traced, along with the approaches for inhibitors discovery. The challenges in identifying novel and selective potent inhibitors of HIF-1alpha-p300/CBP are also put forward.
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Quinuclidine – Wikipedia,
Quinuclidine | C7H479N | ChemSpider