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Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis. An amide derivative represented by the following formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof.

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Quinuclidine – Wikipedia,
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The invention relates to substituted benzoylguanidines of formula (I), where R1 to R8, X and Y have the meanings given in the claims and the pharmaceutically-acceptable salts thereof which are substituted acylguanidines and inhibit cellular Sodium/Proton antiporter (Na+/H+-Exchanger, NHE). Compounds of formula (I) and the pharmaceutically-acceptable salts thereof are suitable for the prevention and treatment of disease caused by activation of or by an activated NHE as a result of the NHE-inhibitory properties thereof and also of secondary diseases caused by damage brought about by the NHE.

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Quinuclidine – Wikipedia,
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The invention is directed to 5,6-dihydro-lH-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

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New Advances in Chemical Research in 2021. Reactions catalyzed within inorganic and organic materials interfaces commonly occur at high coverage, causing turnover rates to depend strongly on interfacial structure and composition, In a patent, 5908-62-3, name is 1,1-Dioxo-isothiazolidine, introducing its new discovery. Reference of 5908-62-3

A robust approach for the synthesis of five and six member sultam is achieved employing commercially available starting materials and reagents. The use of simplest reactions without any critical parameter is the key strength of this route applicable on large scale synthesis.

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Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of 1,1-Dioxo-isothiazolidine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5908-62-3, in my other articles.

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The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.

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Quinuclidine – Wikipedia,
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The high-field 1H NMR spectra of 1,3-propanesultams (2), 2,4-butanesultams (3) and 2,4-dimethyl-1,3-butadienesultams (6) are reported.Comparison of 2, 3 and 6 with 1,3-propanesultone (1) and 2,4-dimethyl-1,3-butadienesultone (5) reveals that the paramaggnetic shift induced by the NH group is smaller than that induced by oxygen.NMR spectra at lower temperatures show coupling effects with the NH proton.A half-chair conformation was deduced for 2,4-butanesultam from coupling constants and from a conformational analysis based on the R values, but a chair-chair interconversion could not be detected in the temperature range between 210 and 330 K.An unambiguous assignment was carried out for the methyl signals in the spectrum of 5 by homodecoupling experiments.

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New discoveries in chemical research and development in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. In a patent, 5908-62-3, name is 1,1-Dioxo-isothiazolidine, introducing its new discovery. Application of 5908-62-3

The invention provides an inner sulfonamide compounds and their preparation method. The invention of the specific method is catalyst C, sulfonamide B, oxidizing agent D reaction in an organic solvent is added, after the separation and purification, to obtain an internal sulfonamide compound E, […] detection after the reaction is finished, then adding the oxidizing agent after the reaction F, inlet separation and purification, to obtain in the sulfonyl imide compound G. The method the catalyst needed is cheap and easy to obtain, low toxicity of the iron complex. When using the sulfonamide H when, through according to the above method after the reaction, and then adding the other additional oxidizing agent F under the condition of, one-pot synthesis in the realization of the sulfonyl imide compound. In the preparation of the sulfonamide and in the sulfonyl imide compound widely used in pharmaceutical chemistry, materials chemistry and the field of organic synthesis. (by machine translation)

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The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. An article , which mentions Application of 5908-62-3, molecular formula is C3H7NO2S. The compound – 1,1-Dioxo-isothiazolidine played an important role in people’s production and life., Application of 5908-62-3

Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment or the delay in the onset of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

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Quinuclidine – Wikipedia,
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This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11beta-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.

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Quinuclidine – Wikipedia,
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A convenient, general, and high yielding Pd-catalyzed cross-coupling of methanesulfonamide with aryl bromides and chlorides is reported. The use of this method eliminates concern over genotoxic impurities that can arise when an aniline is reacted with methanesulfonyl chloride. The application of this method to the synthesis of dofetilide is also reported.

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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H585N | ChemSpider