Category: 94-41-7

COA of Formula: C15H12O. In 2019.0 ORG LETT published article about VINYLOGOUS MICHAEL ADDITION; ENANTIOSELECTIVE CONSTRUCTION; STEREOGENIC CENTERS; ALDOL REACTIONS; C-C; BUTYROLACTAM; EFFICIENT; DESYMMETRIZATION; STEREOCENTERS; BUTENOLIDES in [Song, Tao; Arseniyadis, Stellios; Cossy, Janine] PSL Res Univ, CNRS, Inst Chem Biol & Innovat CBI, ESPCI Paris,Lab Chim Organ, 10 Rue Vauquelin, F-75231 Paris 05, France; [Arseniyadis, Stellios] Queen Mary Univ London, Sch Biol & Chem Sci, Mile End Rd, London E1 4NS, England in 2019.0, Cited 70.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

The synthesis of chiral unsaturated gamma-lactams is reported featuring a highly enantioselective palladium-catalyzed asymmetric allylic alkylation of alpha,gamma-disubstituted 2-silyloxypyrroles. This method allows a straightforward access to optically active gamma-lactams bearing an alpha-quaternary stereogenic center in high yields (up to 93%), high regioselectivities (up to >20:1), and excellent enantioselectivities (up to 95% ee). To further demonstrate the synthetic utility of the method, the resulting allylated products were converted to various versatile chiral building blocks, such as pyrrolidines and pyrrolidinones.

COA of Formula: C15H12O. About Chalcone, If you have any questions, you can contact Song, T; Arseniyadis, S; Cossy, J or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

I found the field of Chemistry; Pharmacology & Pharmacy very interesting. Saw the article In vitroantiproliferative activity of glabridin derivatives and theirin silicotarget identification published in 2020.0. Recommanded Product: 94-41-7, Reprint Addresses Bhakuni, RS (corresponding author), CSIR Cent Inst Med & Aromat Plants, Med Chem Dept, Lucknow, Uttar Pradesh, India.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

Novel Mannich base derivatives of glabridin were synthesized and their antiproliferative activity were performed along with our previously reported glabridin-chalcone hybrids molecules (GCHMs) against various human cell lines MDA-MB-231 (breast adenocarcinoma), HEK-293 (embryonic kidney cell line), K562 (leukemia), MCF-7 (breast adenocarcinoma), HeLa (cervix adenocarcinoma), HepG2 (hepatocellular carcinoma) and WRL-68 (hepatic carcinoma). The result showed that the glabridin significantly reduced cell proliferation with IC(50)ranges from 3.67 to 58.30 mu M against all the tested cell lines. The remarkable reduction in antiproliferative activity 2′,4′-dimethoxyglabridin and GCHMs compounds with phenolic OH groups protected by methoxy (OCH3) groups suggested that the free OH groups are essential factor for the antiproliferative activity of glabridin and its derivatives. The Mannich base derivatives of glabridin showed moderate activity IC50(2.20->95.78 mu M). Furthermore,in silicotarget identification analysis revealed that AKT1, DECR1 and NOS1 are the potential targets for glabridin and their derivatives.

Recommanded Product: 94-41-7. About Chalcone, If you have any questions, you can contact Kapkoti, DS; Singh, S; Alam, S; Khan, F; Luqman, S; Bhakuni, RS or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Application In Synthesis of Chalcone. In 2019.0 RSC ADV published article about BACTERIAL LEAF-BLIGHT; ORYZAE PV. ORYZAE; ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; MOLECULAR DOCKING; RESISTANCE GENES; DESIGN; ANTICANCER; HYBRIDS; CYTOTOXICITY in [Guo, Tao; Xia, Ronqjiao; Chen, Mei; He, Jun; Su, Shijun; Liu, Liwei; Li, Xiangyang; Xue, Wei] Guizhou Univ, Ctr Res & Dev Fine Chem, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,State Key Lab Breeding Base Green Pes, Guiyang 550025, Guizhou, Peoples R China in 2019.0, Cited 51.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

A series of novel chalcone derivatives containing a thiophene sulfonate group were designed and synthesized. The structures of all title compounds were determined by H-1-NMR, C-13-NMR and HRMS. Antibacterial bioassays indicated that, compound 2l demonstrated excellent antibacterial activities against Xanthomonas axonopodis pv. citri (Xac), with an EC50 value of 11.4 mu g mL(-1), which is significantly superior to those of bismerthiazol (BT) (51.6 mu g mL(-1)) and thiodiazole-copper (TC) (94.7 mu g mL(-1)). Meanwhile, the mechanism of action of compound 2l was confirmed by using scanning electron microscopy (SEM). In addition, compound 2e showed remarkable inactivation activity against Tobacco mosaic virus (TMV), with an EC50 value of 44.3 mu g mL(-1), which was superior to that of ningnanmycin (120.6 mu g mL(-1)). Microscale thermophoresis (MST) also showed that the binding of compounds 2e and 2h to Tobacco mosaic virus coat protein (TMV-CP) yielded K-d values of 0.270 and 0.301 mu mol L-1, which are better than that of ningnanmycin (0.596 mu mol L-1). At the same time, molecular docking studies for 2e and 2h with TMV-CP (PDB code: ; 1EI7) showed that the compound was embedded well in the pocket between the two subunits of TMV-CP in each case. These results suggested that chalcone derivatives containing a thiophene sulfonate group may be considered as activators in the design of antibacterial and antiviral agents.

Application In Synthesis of Chalcone. About Chalcone, If you have any questions, you can contact Guo, T; Xia, ROJ; Chen, M; He, J; Su, SJ; Liu, LW; Li, XY; Xue, W or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

I found the field of Chemistry; Science & Technology – Other Topics; Engineering very interesting. Saw the article In Situ Sulfidation of Pd/C: A Straightforward Method for Chemoselective Conjugate Reduction by Continuous Hydrogenation published in 2019.0. Safety of Chalcone, Reprint Addresses George, MW (corresponding author), Univ Nottingham, Sch Chem, Univ Pk, Nottingham NG7 2RD, England.; George, MW (corresponding author), Univ Nottingham Ningbo China, Dept Chem & Environm Engn, 199 Taikang East Rd, Ningbo 315100, Zhejiang, Peoples R China.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

A method has been developed for the in situ sulfidation of Pd/C under continuous flow. The approach provides a cheap, sustainable, and operationally convenient method for chemoselective conjugate reduction by continuous hydrogenation. High conversions and excellent selectivities were obtained for olefin reduction in alpha/beta-unsaturated carbonyl compounds in the presence of hydrogenatively sensitive functionalities. The methodology was analyzed with a green metric system to highlight the sustainability features of the process.

About Chalcone, If you have any questions, you can contact Moore, JC; Howie, RA; Bourne, SL; Jenkins, GN; Licence, P; Poliakoff, M; George, MW or concate me.. SDS of cas: 94-41-7

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

SDS of cas: 94-41-7. In 2021.0 MOLECULES published article about TIME-OF-FLIGHT; LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY in [Cortes-Chitala, Maria del Carmen; Flores-Martinez, Hector; Leon-Campos, Carolina; Lopez-Muraira, Irma] TecNM ITTlajomulco, Km 10 Carretera Tlajomulco San Miguel Cuyutlan, Tlajomulco De Zuniga 45640, Jalisco, Mexico; [Orozco-Avila, Ignacio; Estarron-Espinosa, Mirna] Ctr Invest & Asistencia Tecnol & Diseno Estado Ja, Tecnol Alimentaria, AC Camino Arenero 1227, Zapopan 45019, Jalisco, Mexico; [Suarez-Jacobo, Angela] Ctr Invest & Asistencia Tecnol & Diseno Estado Ja, Biotecnol Ind, AC Camino Arenero 1227, Zapopan 45019, Jalisco, Mexico in 2021.0, Cited 49.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Plants have been used for thousands of years for various purposes because they have a wide variety of activities with biological significance. Mexican oregano is an aromatic plant of great importance to Mexico and north of Jalisco state as a spice with important economic value. Chromatographic identification and quantification of phenolic compounds and evaluation of their antioxidant activity were important tools to obtain a better characterization of this spice. Phytochemical analysis indicated the presence of flavonoids, triterpenes, saponins, quinones and tannins, the latter at high concentrations. Through chromatographic assays of Mexican oregano extracts, 62 compounds were identified, the major ones being quantified as: taxifolin, apigenin 7-O-glucoside, phlorizin, eriodictyol, quercetin, naringenin, hispidulin, pinocembrin, galangin and genkwanin (compound for the first time reported for this species). The results can be useful as a precedent to establish the bases of new quality characterization parameters and they have also suggested that Mexican oregano contains a wide variety of compounds with untapped importance for the development of new high value-added products.

SDS of cas: 94-41-7. About Chalcone, If you have any questions, you can contact Cortes-Chitala, MD; Flores-Martinez, H; Orozco-Avila, I; Leon-Campos, C; Suarez-Jacobo, A; Estarron-Espinosa, M; Lopez-Muraira, I or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Abscisic acid and stress induced by salt: Effect on the phenylpropanoid, L-ascorbic acid and abscisic acid metabolism of strawberry fruits WOS:000536123200021 published article about FRAGARIA-X-ANANASSA; PHENYLALANINE AMMONIA-LYASE; TIME-QUANTITATIVE PCR; DIFFERENT CULTIVARS; GENE-EXPRESSION; DROUGHT STRESS; TOLERANCE; PROLINE; PLANT; MECHANISMS in [Crizel, R. L.; Perin, E. C.; Siebeneichler, T. J.; Borowski, J. M.; Messias, R. S.; Rombaldi, C., V; Galli, V] Univ Fed Pelotas, Pelotas, RS, Brazil in 2020.0, Cited 65.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Computed Properties of C15H12O

Strawberry is one of the most popular fruits because of its sensorial and functional properties. However, strawberry crop is sensitive to salt stress conditions. Despite plants have plasticity, high salt concentrations induce molecular, biochemical, and physiological responses in plants. There is evidence that the abscisic acid (ABA) hormone acts as a signaling molecule under stress conditions; however, the molecular mechanisms involved in the synthesis and homeostasis of ABA and in the induction of phytochemical antioxidant compounds under stress conditions remain unclear. In this study, the effect of stress induced by NaCl (salt stress – SS), with or without the simultaneous application of ABA, on the ABA, phenylpropanoids and L-ascorbic acid (AsA) metabolisms were evaluated. The physiological aspects (Na, Cl and proline concentration, photosynthetic variables) were also studied. The results showed that salt stress increases the Na and Cl content in the leaves, affects photosynthetic variables and triggers the production of proline, pelargonidin-3-O-glucoside, total phenolic compounds and AsA content, alongside the upregulation of several genes from the phenylpropanoid and flavonoid pathways. These effects were accompanied by the induction of compounds and transcripts related to ABA biosynthesis, conjugation and catabolism. Otherwise, the exogenous application of ABA in salt stressed plants promotes a shift in gene expression and metabolism to mitigate the stress. Therefore, salt stress affects the metabolism of ABA, phenylpropanoids and AsA in strawberry increasing phytochemical composition which is strongly associated with an ABA-dependent mechanism.

Computed Properties of C15H12O. About Chalcone, If you have any questions, you can contact Crizel, RL; Perin, EC; Siebeneichler, TJ; Borowski, JM; Messias, RS; Rombaldi, CV; Galli, V or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Category: thiazolidines. Ray, U; Raul, SK; Gopinatha, VK; Ghosh, D; Rangappa, KS; Mantelingu, K; Raghavan, SC in [Ray, Ujjayinee; Raul, Sanjay Kumar; Ghosh, Dipayan; Raghavan, Sathees C.] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India; [Gopinatha, Vindya K.; Rangappa, Kanchugarakoppal S.; Mantelingu, Kempegowda] Univ Mysore, Dept Studies Chem, ManasaganFindo Frgotri, Mysuru, India published Identification and characterization of novel SCR7-based small-molecule inhibitor of DNA end-joining, SCR130 and its relevance in cancer therapeutics in 2020.0, Cited 47.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Targeting DNA repair with small-molecule inhibitors is an attractive strategy for cancer therapy. Majority of DNA double-strand breaks in mammalian cells are repaired through nonhomologous end-joining (NHEJ). It has been shown that small-molecule inhibitors of NHEJ can block efficient repair inside cancer cells, leading to cell death. Previously, we have reported that SCR7, an inhibitor of NHEJ can induce tumor regression in mice. Later studies have shown that different forms of SCR7 can inhibit DNA end-joining in Ligase IV-dependent manner. Recently, we have derivatized SCR7 by introducing spiro ring into core structure. Here, we report the identification of a novel inhibitor of NHEJ, named SCR130 with 20-fold higher efficacy in inducing cytotoxicity in cancer cell lines. SCR130 inhibited DNA end-joining catalyzed by rat tissue extract. Specificity analysis revealed that while SCR130 was specific to Ligase IV, it showed minimal or no effect on Ligase III and Ligase I mediated joining. Importantly, SCR130 exhibited the least cytotoxicity in Ligase IV-null cell line as compared with wild type, confirming Ligase IV-specificity. Furthermore, we demonstrate that SCR130 can potentiate the effect of radiation in cancer cells when used in combination with gamma-radiation. Various cellular assays in conjunction with Western blot analysis revealed that treatment with SCR130 led to loss of mitochondrial membrane potential leading to cell death by activating both intrinsic and extrinsic pathways of apoptosis. Thus, we describe a novel inhibitor of NHEJ with higher efficacy and may have the potential to be developed as cancer therapeutic.

Category: thiazolidines. About Chalcone, If you have any questions, you can contact Ray, U; Raul, SK; Gopinatha, VK; Ghosh, D; Rangappa, KS; Mantelingu, K; Raghavan, SC or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In 2021 J MOL LIQ published article about DENSITY-FUNCTIONAL THERMOCHEMISTRY; TERMINAL ALKYNES; ETHYL LACTATE; EFFICIENT; PERTURBATION; DERIVATIVES; COMPLEXES; ALDEHYDES; KETONES in [Dandia, Anshu; Saini, Pratibha; Parewa, Vijay] Univ Rajasthan, Ctr Adv Studies, Dept Chem, Jaipur, Rajasthan, India; [Chithra, M. J.; Vennapusa, Sivaranjana Reddy] Indian Inst Sci Educ & Res Thiruvananthapuram, Maruthamala PO, Thiruvananthapuram 695551, Kerala, India in 2021, Cited 62. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Name: Chalcone

An efficient and sustainable protocol for the hydration of alkynes has been developed under metal/acid/catalyst/ ligand-free conditions in a water/ethyl lactate mixture. The hydrogen-bond network in the ethyl lactate and water mixture plays a crucial and decisive role in activating the alkynes for hydration to afford the corresponding methyl ketones. This strategy gives the Markovnikov (ketone) addition product selectively over other possible products. The essential role of hydrogen bonding has been confirmed by experimental and theoretical techniques. A probable mechanism has been suggested by various control tests. The efficacy of the method has been further explored for the competent production of value-added alpha,beta-unsaturated carbonyl compounds through the reaction of aldehydes with alkynes as ketonic surrogates. The environmentally benign hydration method takes place under mild conditions, has broad functional-group compatibility, and uses the ethyl lactate/water (1:3) medium as a green alternative in the absence of any hazardous, harmful, or expensive substances. (C) 2021 Elsevier B.V. All rights reserved.

About Chalcone, If you have any questions, you can contact Dandia, A; Saini, P; Chithra, MJ; Vennapusa, SR; Parewa, V or concate me.. Product Details of 94-41-7

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Kim, S; Jeong, YJ; Park, SH; Park, SC; Lee, SB; Lee, J; Kim, SW; Ha, BK; Kim, HS; Kim, H; Ryu, Y; Jeong, JC; Kim, CY in MDPI published article about PHARMACEUTICAL APPLICATIONS; VAR ANGUSTIFOLIA; FLAVONOIDS; BIOSYNTHESIS; GENES; EXPRESSION; MEDICARPIN; MAACKIAIN in [Kim, Soyoung; Jeong, Yu Jeong; Park, Su Hyun; Park, Sung-Chul; Lee, Saet Buyl; Lee, Jiyoung; Kim, Suk Weon; Jeong, Jae Cheol; Kim, Cha Young] Korea Res Inst Biosci & Biotechnol KRIBB, Biol Resource Ctr, Jeongeup 56212, South Korea; [Kim, Soyoung; Ha, Bo-Keun] Chonnam Natl Univ, Coll Agr & Life Sci, Dept Plant Biotechnol, Gwangju 61186, South Korea; [Kim, Hyun-Soon; Kim, HyeRan] Korea Res Inst Biosci & Biotechnol KRIBB, Plant Syst Engn Res Ctr, Daejeon 34141, South Korea; [Ryu, Young] Korea Res Inst Biosci & Biotechnol KRIBB, Funct Biomat Res Ctr, Jeongeup 56212, South Korea in 2020.0, Cited 47.0. Application In Synthesis of Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Pterocarpans are derivatives of isoflavonoids, found in many species of the family Fabaceae. Sophora flavescens Aiton is a promising traditional Asian medicinal plant. Plant cell suspension cultures represent an excellent source for the production of valuable secondary metabolites. Herein, we found that methyl jasmonate (MJ) elicited the activation of pterocarpan biosynthetic genes in cell suspension cultures of S. flavescens and enhanced the accumulation of pterocarpans, producing mainly trifolirhizin, trifolirhizin malonate, and maackiain. MJ application stimulated the expression of structural genes (PAL, C4H, 4CL, CHS, CHR, CHI, IFS, I3’H, and IFR) of the pterocarpan biosynthetic pathway. In addition, the co-treatment of MJ and methyl-beta-cyclodextrin (Me beta CD) as a solubilizer exhibited a synergistic effect on the activation of the pterocarpan biosynthetic genes. The maximum level of total pterocarpan production (37.2 mg/g dry weight (DW)) was obtained on day 17 after the application of 50 mu M MJ on cells. We also found that the combined treatment of cells for seven days with MJ and Me beta CD synergistically induced the pterocarpan production (trifolirhizin, trifolirhizin malonate, and maackiain) in the cells (58 mg/g DW) and culture medium (222.7 mg/L). Noteworthy, the co-treatment only stimulated the elevated extracellular production of maackiain in the culture medium, indicating its extracellular secretion; however, its glycosides (trifolirhizin and trifolirhizin malonate) were not detected in any significant amounts in the culture medium. This work provides new strategies for the pterocarpan production in plant cell suspension cultures, and shows Me beta CD to be an effective solubilizer for the extracellular production of maackiain in the cell cultures of S. flavescens.

About Chalcone, If you have any questions, you can contact Kim, S; Jeong, YJ; Park, SH; Park, SC; Lee, SB; Lee, J; Kim, SW; Ha, BK; Kim, HS; Kim, H; Ryu, Y; Jeong, JC; Kim, CY or concate me.. Quality Control of Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Computed Properties of C15H12O. In 2020.0 BEILSTEIN J ORG CHEM published article about SP(3) C-H; PYRIDINIUM SALTS; PHOTOREDOX CATALYSIS; ORGANIC-SYNTHESIS; BOND; FUNCTIONALIZATION; ACTIVATION; EFFICIENT; REAGENTS in [Schoenbauer, David; Schnuerch, Michael] TU Wien, Inst Appl Synthet Chem, Getreidemarkt 9-163, A-1060 Vienna, Austria; [Sambiagio, Carlo; Noel, Timothy] Eindhoven Univ Technol, Dept Chem Engn & Chem, Micro Flow Chem & Synthet Methodol, Den Dolech 2, NL-5612 AZ Eindhoven, Netherlands in 2020.0, Cited 52.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

A ruthenium-catalyzed photoredox coupling of substituted N-aryltetrahydroisoquinolines (THIQs) and different bench-stable pyridinium salts was successfully developed to give fast access to 1-benzyl-THIQs. Furthermore, secondary alkyl and allyl groups were also successfully introduced via the same method. Additionally, the typically applied N-phenyl group in the THIQ substrate could be replaced by the cleavable p-methoxyphenyl (PMP) group and successful N-deprotection was demonstrated.

Computed Properties of C15H12O. About Chalcone, If you have any questions, you can contact Schonbauer, D; Sambiagio, C; Noel, T; Schnurch, M or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com