Category: 94-41-7

Recently I am researching about PHOSPHATE STARVATION RESPONSES; SYSTEM ARCHITECTURE; SUGAR; ARABIDOPSIS; BIOSYNTHESIS; PLANTS; ACID; EXPRESSION; GENES; IDENTIFICATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31872854]; Key Project of Liaoning Natural Science Foundation [20170540809]. Published in HINDAWI LTD in LONDON ,Authors: Yang, A; Kong, LJ; Wang, H; Yao, XD; Xie, FT; Wang, HY; Ao, X. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone. Name: Chalcone

Phosphorus (P) is one the least available essential plant macronutrients in soils that is a major constraint on plant growth. Soybean (Glycine max L.) production is often limited due to low P availability. The better management of P deficiency requires improvement of soybean’s P use efficiency. Sugars are implicated in P starvation responses, and a complete understanding of the role of sucrose together with P in coordinating P starvation responses is missing in soybean. This study explored global metabolomic changes in previously screened low-P-tolerant (Liaodou, L13) and low-P-sensitive (Tiefeng 3, T3) soybean genotypes by liquid chromatography coupled mass spectrometry. We also studied the root morphological response to sucrose application (1%) in P-starved soybean genotypes against normal P supply. Root morphology in L13 genotype has significantly improved P starvation responses as compared to the T3 genotype. Exogenous sucrose application greatly affected root length, root volume, and root surface area in L13 genotype while low-P-sensitive genotype, i.e., T3, only responded by increasing number of lateral roots. Root : shoot ratio increased after sucrose treatment regardless of P conditions, in both genotypes. T3 showed a relatively higher number of differentially accumulated metabolites between P-starved and normal P conditions as compared to L13 genotype. Common metabolites accumulated under the influence of sucrose were 5-O-methylembelin, D-glucuronic acid, and N-acetyl-L-phenylalanine. We have discussed the possible roles of the pathways associated with these metabolites. The differentially accumulated metabolites between both genotypes under the influence of sucrose are also discussed. These results are important to further explore the role of sucrose in the observed pathways. Especially, our results are relevant to formulate strategies for improving P efficiency of soybean genotypes with different P efficiencies.

About Chalcone, If you have any questions, you can contact Yang, A; Kong, LJ; Wang, H; Yao, XD; Xie, FT; Wang, HY; Ao, X or concate me.. Name: Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article On the development of a nucleophilic methylthiolation methodology WOS:000550965600014 published article about ENANTIOSELECTIVE TOTAL-SYNTHESIS; S BOND FORMATION; NANOPARTICLES; SULFOXIDES; OXIDATION; SULFIDES; SULFONES in [Portinho de Puga Carvalho, Bernardo Basbaum; Pereira Amaral, Adriane Antonia; de Castro, Pedro Possa; Moreira Ferreira, Fernanda Cerqueira; Amarante, Giovanni Wilson] Univ Fed Juiz de Fora, Chem Dept, Campus Martelos, BR-36036900 Juiz De Fora, MG, Brazil; [Cautiero Horta, Bruno Araujo] Univ Fed Rio de Janeiro, CT Ctr Tecnol, Chem Inst, BR-21941909 Rio De Janeiro, Brazil in 2020, Cited 34. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. COA of Formula: C15H12O

Methylthiolation reactions are usually explored to access organosulfur compounds using methanethiol, an extremely flammable and toxic compound. Herein, methylthiomethyl esters were successfully applied as novel methylthiolation reagents in a low cost, transition-metal-free methodology. These reagents allowed the methylthiolation of a wide scope of chalcones, acyl ester derivatives and Morita-Baylis-Hillman acetates with good group tolerance, affording the methylthiolated products in moderate to excellent yields. The reaction mechanism was investigated through several control experiments, as well as by theoretical calculations employing Density Functional Theory. The results strongly support that a sulfurane and a sulfonium ylide appear as key intermediates and that a Pummerer type rearrangement is also crucial for the formation of this novel reagent. Furthermore, the methylthiolation mechanism is likely to proceed through the nucleophilic attack of the reagent, followed by an entropically favoured step involving the acetate attack to the positively charged species, then releasing the product.

COA of Formula: C15H12O. About Chalcone, If you have any questions, you can contact Carvalho, BBPD; Amaral, AAP; de Castro, PP; Ferreira, FCM; Horta, BAC; Amarante, GW or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Vijayalakshmi, RV; Kuppan, R; Kumar, PP in ELSEVIER published article about LUMINESCENCE PROPERTIES; SNO2 NANOPARTICLES; GAS SENSOR; DOPED ZNO; EMISSION; VACANCY in [Vijayalakshmi, R. Vanathi] Queen Marys Coll, Dept Phys, Chennai 600004, Tamil Nadu, India; [Kuppan, Ravichandran] Univ Madras, Dept Nucl Phys, Guindy Campus, Chennai 600025, Tamil Nadu, India; [Kumar, P. Praveen] Presidency Coll, Dept Phys, Chennai 600005, Tamil Nadu, India in 2020.0, Cited 55.0. Formula: C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

This manuscript details the impact of stabilizing agents on the structural, optical properties of Ag@SnO2 core shell nanoparticles and its biological applications. Three different stabilizing agent viz. Poly Vinyl Pyrrolidone (PVP), zeroth generation triazolyl glycodendrimer and zeroth generation triazolyl chalcone dendrimer were used as stabilizers in the synthesis of Ag@SnO2 nanoparticles. The results were compared to study their effect on the structural and optical properties of the synthesized samples. The structural parameters of the samples were investigated by XRD analysis, FESEM and HRTEM images. The presence of SnO2 shell on the Ag core was also corroborated by XPS results. The XRD data was used for refining and characterizing the elements present in the sample by Reitveld method. The average crystallite size, dislocation density, lattice parameters (a, c), lattice strain of the samples were calculated using XRD measurements. Williamson – Hall (W-H) method and Size Strain Plot (SSP) method were used to calculate the lattice strain of the synthesized sample. The concentric rings of the SAED pattern and the lattice fringe images exhibited the interplanar d-spacing values and the results were compared with XRD measurements. The optical properties of the samples were investigated using UV-Vis spectra and the band gap energy were calculated using Tauc plot. The Photoluminescence (PL) studies of the Ag@SnO2 core – shell nanoparticles with the three stabilizing agents are also discussed in this work. The antibacterial and antifungal activities of the chalcone dendrimer stabilized Ag@SnO2 core – shell nanoparticles were tested against the pathogens Bacillus subtilis, Proteus mirabilis, Candida albicans and Aspergillus niger. (C) 2020 Elsevier B.V. All rights reserved.

Formula: C15H12O. About Chalcone, If you have any questions, you can contact Vijayalakshmi, RV; Kuppan, R; Kumar, PP or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Oxovanadium(v)-catalyzed oxidative cross-coupling of enolates using O-2 as a terminal oxidant WOS:000574031500030 published article about CARBON BOND FORMATION; 1,4-DIKETONES; ENAMINES; SILANES; ETHERS; ACTIVATION; GENERATION; RADICALS in [Osafune, Yuma; Jin, Yuqing; Hirao, Toshikazu; Tobisu, Mamoru; Amaya, Toru] Osaka Univ, Grad Sch Engn, Suita, Osaka 5650871, Japan; [Hirao, Toshikazu] Osaka Univ, Inst Sci & Ind Res, Ibaraki, Osaka 5670047, Japan in 2020.0, Cited 37.0. Name: Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

The oxovanadium(v)-catalyzed oxidative cross-coupling of enolates using O(2)as a terminal oxidant is reported, where a boron enolate and a silyl enol ether were employed as enolates. The redox behavior of V(v/iv) in this reaction under O(2)was investigated by ESR and(51)V NMR experiments.

Name: Chalcone. About Chalcone, If you have any questions, you can contact Osafune, Y; Jin, YQ; Hirao, T; Tobisu, M; Amaya, T or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Diels-Alder route to norbornane derived vicinal phosphane/borane frustrated Lewis pairs for the metal-free catalytic hydrogenation of alpha, beta-unsaturated ketones WOS:000485104600004 published article about HETEROLYTIC DIHYDROGEN ACTIVATION; ELECTRONIC CONTROL; CHEMISTRY; REDUCTION; BIS(PENTAFLUOROPHENYL)BORANE; STEREOSELECTIVITY in [Woelke, Christian; Daniliuc, Constantin G.; Kehr, Gerald; Erker, Gerhard] Westfalische Wilhelms Univ Munster, Organ Chem Inst, Corrensstr 40, D-48149 Munster, Germany in 2019.0, Cited 56.0. Product Details of 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

The [4+2] cycloaddition reaction of the (dimesitylphosphino) cyclopentadienes 5a,b with N-phenyl-maleimide gave the norbornene derivative 9. Its reduction with LiAlH4 produced the N-phenyl-pyrrolidino-annulated system 10. Treatment with Piers’ borane gave the respective P/B FLP 12 as the major product, which cleaved dihydrogen under mild conditions to yield the phosphonium/hydrido borate product 14. Reaction of the phosphino-norbornene 10 with 2 M equiv. of Piers’ borane [HB(C6F5)(2)] followed by exposure to dihydrogen eventually gave the HB(C6F5)(2) adduct 15. This served as a catalyst for the hydrogenation of a series of chalcone derivatives. The system requires a pre-activation period before becoming active for the conjugated enone hydrogenation. (C) 2019 Elsevier B.V. All rights reserved.

Product Details of 94-41-7. About Chalcone, If you have any questions, you can contact Wolke, C; Daniliuc, CG; Kehr, G; Erker, G or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

COA of Formula: C15H12O. In 2020.0 CHEM HETEROCYCL COM+ published article about 1,10-PHENANTHROLINE; COMPLEXES; LIGANDS in [Sannikova, Viktoriya A.; Filippov, Igor R.; Karmatskikh, Oleg Yu.; Panfilov, Mikhail A.; Andreev, Rodion V.; Vorob’ev, Aleksey Yu.] Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Akad Lavrentieva Ave, Novosibirsk 630090, Russia; [Filippov, Igor R.; Karmatskikh, Oleg Yu.; Vorob’ev, Aleksey Yu.] Novosibirsk State Univ, 1 Pirogova St, Novosibirsk 630090, Russia in 2020.0, Cited 20.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

The reaction ofN-amino-1,10-phenanthrolinium mesitylenesulfonate with acceptor-substituted alkenes in the K2CO3-DMSO system gave 3- and 2,3-substituted pyrazolo[1,5-a][1,10]phenanthrolines. A wide range of alkenes enter into this reaction; however, in the case of nitro derivatives, complex mixtures of products were formed.

COA of Formula: C15H12O. About Chalcone, If you have any questions, you can contact Sannikova, VA; Filippov, IR; Karmatskikh, OY; Panfilov, MA; Andreev, RV; Vorob’ev, AY or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy very interesting. Saw the article Rationally synthesized coumarin based pyrazolines ameliorate carrageenan induced inflammation through COX-2/pro-inflammatory cytokine inhibition published in 2019.0. Category: thiazolidines, Reprint Addresses Gill, RK (corresponding author), ISF Coll Pharm, Dept Pharmaceut Chem, Moga 142001, Punjab, India.; Singh, G (corresponding author), Indian Inst Technol Ropar, Dept Chem, Ropar 140001, Punjab, India.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

In the present work, coumarin based pyrazolines (7a-g) have been synthesized and investigated for their in vitro and in vivo anti-inflammatory potential. Amongst the synthesized compounds, compounds 7a, 7d and 7f exhibited significant in vitro anti-inflammatory activity as compared to the standard etoricoxib. Keeping this in mind, in vivo investigations were carried out via carrageenan induced inflammation and acetic acid induced writhing models in male Wistar rats and compound 7a was found to possess appreciable anti-inflammatory and analgesic potential. The mode of action of compound 7a was also investigated by using substance P as the biomarker, which shows promising results. Further, the selectivity of the most active compound 7a against the cyclooxygenase enzyme was supported by molecular docking studies which reveal that compound 7a has greater binding affinity towards COX-2 over COX-1 and 5-LOX enzymes. In silico ADME analysis of compound 7a confirms the drug-like characteristics and the in vivo acute toxicity study showed the safety of the compound even up to a 2000 mg kg(-1) dose. Thus, compound 7a was identified as an effective anti-inflammatory agent, and can be explored for further analgesic/anti-inflammatory drug design and development.

Category: thiazolidines. About Chalcone, If you have any questions, you can contact Chandel, P; Kumar, A; Singla, N; Kumar, A; Singh, G; Gill, RK or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Name: Chalcone. I found the field of Science & Technology – Other Topics very interesting. Saw the article Water hyacinth ash: an efficient green catalyst for the synthesis of beta-amino carbonyl/nitrile compounds by aza-Michael reaction at room temperature published in 2020.0, Reprint Addresses Deka, DC (corresponding author), Gauhati Univ, Dept Chem, Gauhati 781014, Assam, India.; Deka, DC (corresponding author), Mahabdev Univ, PO Dikrong, Narayanpur 784164, Assam, India.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone.

Water hyacinth ash is found to be an efficient and reusable catalyst for the synthesis of beta-amino carbonyl/nitrile compounds by aza-Michael reaction of amines with alpha,beta-unsaturated compounds at room temperature under solvent free condition. Due to low cost of the catalyst, good activity, ease of handling and easy recovery with high yields of the products in short reaction time, easy workup procedure, mild reaction condition, the protocol is highly applicable in synthetic organic chemistry.

About Chalcone, If you have any questions, you can contact Talukdar, A; Deka, DC or concate me.. Name: Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Safety of Chalcone. In 2019.0 FOOD CHEM TOXICOL published article about OXIDATIVE STRESS; IN-VITRO; SIGNALING PATHWAY; NRF2; ANTIOXIDANTS; INFLAMMATION; DERIVATIVES; EXPRESSION; FLAVONOIDS; 3D-QSAR in [Li, Maiquan; Jie, Fan; Wang, Mengmeng; Zhong, Yongheng; Chen, Qi; Lu, Baiyi] Zhejiang Univ, Natl Engn Lab Intelligent Food Technol & Equipmen, Zhejiang Key Lab Agrofood Proc,Fuli Inst Food Sci, Minist Agr,Coll Biosyst Engn & Food Sci,Key Lab A, Hangzhou 310058, Zhejiang, Peoples R China; [Li, Maiquan] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410208, Hunan, Peoples R China; [Huang, Weisu] Zhejiang Econ & Trade Polytech, Dept Appl Technol, Hangzhou 310018, Zhejiang, Peoples R China in 2019.0, Cited 31.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Various phytochemicals have been reported to protect against oxidative stress. However, the mechanism underlying has not been systematically evaluated, which limited their application in disease treatment. Nuclear factor erythroid 2 – related factor 2 (Nrf2), a central transcription factor in oxidative stress response related to numerous diseases, is activated after dissociating from the cytoskeleton – anchored Kelch – like ECH – associated protein 1 (Keap1). The Keap1-Nrf2 protein-protein interaction has become an important drug target. This study was designed to clarify whether antioxidantive phytochemicals inhibit the Keap1-Nrf2 protein-protein interaction and activate the Nrf2-ARE signaling pathway efficiently. Molecular docking and 3D – QSAR were applied to evaluate the interaction effects between 178 antioxidant phytochemicals and the Nrf2 binding site in Keap1. The Nrf2 activation effect was tested on a H2O2 – induced oxidative – injured cell model. Results showed that the 178 phytochemicals could be divided into high – , medium – , and low – total -score groups depending on their binding affinity with Keap1, and the high total – score group consisted of 24 compounds with abundant oxygen or glycosides. Meanwhile, these compounds could bind with key amino acids in the structure of the Keap1 – Nrf2 interface. Compounds from high – total – score group show effective activation effects on Nrf2. In conclusion, phytochemicals showed high binding affinity with Keapi are promising new Nrf2 activators.

Safety of Chalcone. About Chalcone, If you have any questions, you can contact Li, MQ; Huang, WS; Jie, F; Wang, MM; Zhong, YH; Chen, Q; Lu, BY or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In 2021.0 J IRAN CHEM SOC published article about ALZHEIMERS-DISEASE; BIOLOGICAL EVALUATION; DERIVATIVES; DRUG; BIS(2-S-ALKYLPYRIDINES); CHALCONES; DOCKING; MOIETY; QSAR in [Sanad, Sherif M. H.; Mekky, Ahmed E. M.] Cairo Univ, Fac Sci, Chem Dept, Giza 12613, Egypt in 2021.0, Cited 59.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Category: thiazolidines

Alzheimer’s disease is a degenerative brain condition that is the leading cause of dementia affecting millions of people around the world. Therapeutic development has focused on the problem of the loss of basal forebrain cholinergic function, as it is the only evidence responsible for brain neurodegeneration in patients with Alzheimer’s disease. Several attempts to improve cholinergic neurotransmission have been investigated by minimizing synaptic degradation of acetylcholine using acetylcholinesterase inhibitors. In the current study, we explore the designing of a new series of nicotinonitrile-coumarin hybrids as potential acetylcholinesterase inhibitors. The new hybrids were prepared utilizing pyridine-2(1H)-thiones as starting precursors. The in vitro acetylcholinesterase (AChE) inhibitory activities were examined for the new nicotinonitrile-coumarin hybrid molecules, when compared with donepezil as a standard drug with IC(50)of 14 nM. Coumarin derivative, linked to 6-(4-nitrophenyl)-4-phenylnicotinonitrile, showed more effective inhibitory activity than the reference donepezil with IC(50)of 13 nM. The free radical-scavenging capabilities against DPPH of the new hybrid derivatives were screened. Additionally, their in vitro cytotoxic activities have been tested against various eukaryotic cells. Furthermore, docking study showed excellent interaction between nicotinonitrile-coumarin hybrids and AChE. [GRAPHICS] .

About Chalcone, If you have any questions, you can contact Sanad, SMH; Mekky, AEM or concate me.. Category: thiazolidines

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com