Category: 94-41-7

Yang, A; Kong, LJ; Wang, H; Yao, XD; Xie, FT; Wang, HY; Ao, X in [Yang, Ahui; Kong, Lingjian; Wang, Hui; Yao, Xingdong; Xie, Futi; Wang, Haiying; Ao, Xue] Shenyang Agr Univ, Coll Agron, Shenyang 110866, Peoples R China published Response of Soybean Root to Phosphorus Deficiency under Sucrose Feeding: Insight from Morphological and Metabolome Characterizations in 2020.0, Cited 57.0. Formula: C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Phosphorus (P) is one the least available essential plant macronutrients in soils that is a major constraint on plant growth. Soybean (Glycine max L.) production is often limited due to low P availability. The better management of P deficiency requires improvement of soybean’s P use efficiency. Sugars are implicated in P starvation responses, and a complete understanding of the role of sucrose together with P in coordinating P starvation responses is missing in soybean. This study explored global metabolomic changes in previously screened low-P-tolerant (Liaodou, L13) and low-P-sensitive (Tiefeng 3, T3) soybean genotypes by liquid chromatography coupled mass spectrometry. We also studied the root morphological response to sucrose application (1%) in P-starved soybean genotypes against normal P supply. Root morphology in L13 genotype has significantly improved P starvation responses as compared to the T3 genotype. Exogenous sucrose application greatly affected root length, root volume, and root surface area in L13 genotype while low-P-sensitive genotype, i.e., T3, only responded by increasing number of lateral roots. Root : shoot ratio increased after sucrose treatment regardless of P conditions, in both genotypes. T3 showed a relatively higher number of differentially accumulated metabolites between P-starved and normal P conditions as compared to L13 genotype. Common metabolites accumulated under the influence of sucrose were 5-O-methylembelin, D-glucuronic acid, and N-acetyl-L-phenylalanine. We have discussed the possible roles of the pathways associated with these metabolites. The differentially accumulated metabolites between both genotypes under the influence of sucrose are also discussed. These results are important to further explore the role of sucrose in the observed pathways. Especially, our results are relevant to formulate strategies for improving P efficiency of soybean genotypes with different P efficiencies.

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Reference:
Thiazolidine – Wikipedia,
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An article Identification and Quantification of Phenolic Compounds from Mexican Oregano (Lippia graveolens HBK) Hydroethanolic Extracts and Evaluation of Its Antioxidant Capacity WOS:000615422400001 published article about TIME-OF-FLIGHT; LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY in [Cortes-Chitala, Maria del Carmen; Flores-Martinez, Hector; Leon-Campos, Carolina; Lopez-Muraira, Irma] TecNM ITTlajomulco, Km 10 Carretera Tlajomulco San Miguel Cuyutlan, Tlajomulco De Zuniga 45640, Jalisco, Mexico; [Orozco-Avila, Ignacio; Estarron-Espinosa, Mirna] Ctr Invest & Asistencia Tecnol & Diseno Estado Ja, Tecnol Alimentaria, AC Camino Arenero 1227, Zapopan 45019, Jalisco, Mexico; [Suarez-Jacobo, Angela] Ctr Invest & Asistencia Tecnol & Diseno Estado Ja, Biotecnol Ind, AC Camino Arenero 1227, Zapopan 45019, Jalisco, Mexico in 2021.0, Cited 49.0. Product Details of 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Plants have been used for thousands of years for various purposes because they have a wide variety of activities with biological significance. Mexican oregano is an aromatic plant of great importance to Mexico and north of Jalisco state as a spice with important economic value. Chromatographic identification and quantification of phenolic compounds and evaluation of their antioxidant activity were important tools to obtain a better characterization of this spice. Phytochemical analysis indicated the presence of flavonoids, triterpenes, saponins, quinones and tannins, the latter at high concentrations. Through chromatographic assays of Mexican oregano extracts, 62 compounds were identified, the major ones being quantified as: taxifolin, apigenin 7-O-glucoside, phlorizin, eriodictyol, quercetin, naringenin, hispidulin, pinocembrin, galangin and genkwanin (compound for the first time reported for this species). The results can be useful as a precedent to establish the bases of new quality characterization parameters and they have also suggested that Mexican oregano contains a wide variety of compounds with untapped importance for the development of new high value-added products.

Product Details of 94-41-7. Welcome to talk about 94-41-7, If you have any questions, you can contact Cortes-Chitala, MD; Flores-Martinez, H; Orozco-Avila, I; Leon-Campos, C; Suarez-Jacobo, A; Estarron-Espinosa, M; Lopez-Muraira, I or send Email.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Zeitoun, H; Khan, Z; Banerjee, K; Salameh, D; Lteif, R in [Zeitoun, Hussein; Salameh, Dominique; Lteif, Roger] Univ St Joseph, Fac Sci, Ctr Anal & Rech, Unite Technol & Valorisat Alimentaire, Campus Sci & Technol,POB 11-514, Beirut 11072050, Lebanon; [Khan, Zareen; Banerjee, Kaushik] ICAR Natl Res Ctr Grapes, Natl Reference Lab, Pune 412307, Maharashtra, India published Antityrosinase Activity of Combretum micranthum, Euphorbia hirta and Anacardium occidentale Plants: Ultrasound Assisted Extraction Optimization and Profiling of Associated Predominant Metabolites in 2020.0, Cited 55.0. Application In Synthesis of Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Tyrosinase is an important component of the enzyme polyphenol oxidase, which upon contact with the phenolic substrates forms the pigment melanin and induces undesirable food browning. The phenolic and triterpenoid compounds that naturally occur in plants are well known as tyrosinase inhibitors. Combretum micranthum (CM) leaves, Euphorbia hirta (EH) plant, and Anacardium occidentale (AO) fruits are traditionally known to have potential anti-tyrosinase activities. The aim of this study was to optimize the ultrasound-assisted extraction of secondary metabolites from these matrices, and to evaluate in tubo the antityrosinase activity of these extracts. Efforts were also taken to profile the secondary metabolites, mainly the phenolic and triterpenoid compounds, in order to understand their probable association with tyrosinase inhibition. The optimal ultrasound-assisted extraction conditions for simultaneous extraction of phenolic, and triterpenoid compounds were determined. The aqueous fraction of these extracts showed significant antityrosinase activity, with the CM leaves exhibiting the strongest inhibitory effect (IC50 of 0.58 g.L-1). The predominant metabolic compounds from these natural extracts were putatively identified by using a high-resolution quadrupole-time of flight (QToF) LC-MS instrument. The high-resolution accurate mass-based screening resulted in identification of 88 predominant metabolites, which included dihydrodaidzein-7-O-glucuronide, micromeric acid, syringic acid, morin, quercetin-3-O-(6 ”-malonyl-glucoside), 4-hydroxycoumarin, dihydrocaffeic acid-3-O-glucuronide, to name some, with less than 5 ppm of mass error.

Application In Synthesis of Chalcone. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.

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Thiazolidine – Wikipedia,
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Authors Chandel, P; Kumar, A; Singla, N; Kumar, A; Singh, G; Gill, RK in ROYAL SOC CHEMISTRY published article about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; CYCLOOXYGENASE-2 COX-2; SUBSTANCE-P; DERIVATIVES; DESIGN; RISK; PROSTAGLANDINS; DENATURATION; CELECOXIB in [Chandel, Priyanka; Singla, Nishu; Kumar, Anshul; Gill, Rupinder Kaur] ISF Coll Pharm, Dept Pharmaceut Chem, Moga 142001, Punjab, India; [Kumar, Anoop] ISF Coll Pharm, Dept Pharmacol, Moga 142001, Punjab, India; [Singh, Gagandeep] Indian Inst Technol Ropar, Dept Chem, Ropar 140001, Punjab, India in 2019.0, Cited 61.0. HPLC of Formula: C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

In the present work, coumarin based pyrazolines (7a-g) have been synthesized and investigated for their in vitro and in vivo anti-inflammatory potential. Amongst the synthesized compounds, compounds 7a, 7d and 7f exhibited significant in vitro anti-inflammatory activity as compared to the standard etoricoxib. Keeping this in mind, in vivo investigations were carried out via carrageenan induced inflammation and acetic acid induced writhing models in male Wistar rats and compound 7a was found to possess appreciable anti-inflammatory and analgesic potential. The mode of action of compound 7a was also investigated by using substance P as the biomarker, which shows promising results. Further, the selectivity of the most active compound 7a against the cyclooxygenase enzyme was supported by molecular docking studies which reveal that compound 7a has greater binding affinity towards COX-2 over COX-1 and 5-LOX enzymes. In silico ADME analysis of compound 7a confirms the drug-like characteristics and the in vivo acute toxicity study showed the safety of the compound even up to a 2000 mg kg(-1) dose. Thus, compound 7a was identified as an effective anti-inflammatory agent, and can be explored for further analgesic/anti-inflammatory drug design and development.

HPLC of Formula: C15H12O. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.

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Thiazolidine – Wikipedia,
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An article Diboron-Mediated Rhodium-Catalysed Transfer Hydrogenation of Alkenes and Carbonyls WOS:000513195800001 published article about WATER; ALKYNES; REDUCTION; HYDROTRIFLUOROMETHYLATION; DIBORATION; H2O in [Lin, Xiao; Wang, Yuhan; Hu, Yan; Zhu, Wanjiang; Dou, Xiaowei] China Pharmaceut Univ, Sch Sci, Dept Chem, Longmian Ave 639, Nanjing 211198, Peoples R China in 2020.0, Cited 49.0. Product Details of 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

A diboron-mediated rhodium-catalysed transfer hydrogenation system using water as the hydrogen donor is developed. In addition to a series of alkenes with good functional group tolerance, this rhodium-based catalytic system also effectively reduces aldehydes and ketones. A plausible mechanism involving the Rh-I-catalysed hydrogen generation and Rh-0-catalysed hydrogenation is proposed for the reaction.

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Thiazolidine – Wikipedia,
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An article Chemoselective Hydrosilylation of the alpha,beta-Site Double Bond in alpha,beta-and alpha,beta,gamma,delta-Unsaturated Ketones Catalyzed by Macrosteric Borane Promoted by Hexafluoro-2-propanol WOS:000535303300032 published article about METAL-FREE HYDROGENATION; ASYMMETRIC CONJUGATE REDUCTION; CROSS-COUPLING REACTIONS; B(C6F5)(3)-CATALYZED TRANSFER; ALPHA,BETA-UNSATURATED KETONES; CARBONYL-COMPOUNDS; N-ALKYLATION; PHARMACOLOGICAL-ACTIVITY; HANTZSCH ESTER; ALDEHYDES in [Zhan, Xiao-Yu; Zhang, Hua; Dong, Yu; Yang, Jian; Wang, Ji-Yu] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China; [Zhan, Xiao-Yu; Zhang, Hua; Dong, Yu; Yang, Jian] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [He, Shuai; Shi, Zhi-Chuan] Southwest Minzu Univ, Chengdu 610041, Peoples R China; [Tang, Lei] Sichuan Univ, West China Hosp, Translat Neurosci Ctr, Lab Anaesthesia & Crit Care Med, Chengdu 610041, Peoples R China; [Tang, Lei] Sichuan Univ, West China Hosp, Dept Anaesthesiol, Chengdu 610041, Peoples R China in 2020.0, Cited 109.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Application In Synthesis of Chalcone

The B(C6F5)(3)-catalyzed chemoselective hydrosilylation of alpha,beta- and alpha,beta,gamma,delta-unsaturated ketones into the corresponding non-symmetric ketones in mild reaction conditions is developed. Nearly 55 substrates including those bearing reducible functional groups such as alkynyl, alkenyl, cyano, and aromatic heterocycles are chemoselectively hydrosilylated in good to excellent yields. Isotope-labeling studies revealed that hexafluoro-2-propanol also served as a hydrogen source in the process.

Application In Synthesis of Chalcone. Welcome to talk about 94-41-7, If you have any questions, you can contact Zhan, XY; Zhang, H; Dong, Y; Yang, J; He, S; Shi, ZC; Tang, L; Wang, JY or send Email.

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Computed Properties of C15H12O. Recently I am researching about BIOLOGICAL EVALUATION, Saw an article supported by the Council of Scientific and Industrial Research (CSIR), New Delhi, IndiaCouncil of Scientific & Industrial Research (CSIR) – India [DST-SERB/EEQ/2017/095]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Vanaparthi, S; Bantu, R; Jain, N; Janardhan, S; Nagarapu, L. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

A new series of 1,2,3-triazole tethered chalcone acetamide derivatives (7a-c & 8a-r) have been synthesized in excellent yields and their structures were determined by analytical and spectral (FT-IR, H-1 NMR, C-13 NMR HRMS) studies. The newly synthesized derivatives were evaluated for their cytotoxic activity against four human cancer cell lines, such as HeLa (Human cervical cancer), A549 (Human alveolar adenocarcinoma), MCF-7 (Human breast adenocarcinoma) and SKNSH (Human brain cancer). Among them, compound 7c exhibited good anti-proliferation activity with HeLa (IC50 7.41 + 0.8 mu M), SKNSH (IC50 8.68 + 1.1 mu M), MCF-7 (IC50 9.76 + 1.3 mu M) and MDA-MB-231, while compounds 7a and 7b showed promising anti-proliferation against above four human cancer cell lines with IC50 7.95-11.62 mu M, respectively, compared with the standard drug Doxorubicin. We explored the probable key active site and binding mode interactions in HDAC8 (PDB ID:3SFH) and EHMT2 (PDB ID:3K5K) proteins. The docking results are complementary to the experimental observations.

Computed Properties of C15H12O. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.

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Thiazolidine – Wikipedia,
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An article Synthesis of multisubstituted arylsulfones via a one-pot, three-component [3+3] benzannulation reaction WOS:000468000000010 published article about CATALYSIS; CHEMISTRY; SULFINYL in [Tang, Xiang-Zheng; Liang, Jie; Zhang, Xue-Jing; Yan, Ming; Chan, Albert S. C.] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China; [Sun, Raymond Wai-Yin] Guangzhou Lee & Man Technol Co Ltd, Guangzhou 511458, Guangdong, Peoples R China in 2019.0, Cited 36.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Computed Properties of C15H12O

A one-pot, three-component [3 + 3] benzannulation reaction of alpha, beta-unsaturated carbonyl compounds, bromoallylic sulfones, and sodium sulfinates had been developed. A series of multisubstituted arylsulfones were prepared with moderate to good yields. This method has the advantages of good step-economy, broad substrate scope and operational simplicity.

Computed Properties of C15H12O. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.

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Thiazolidine – Wikipedia,
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COA of Formula: C15H12O. In 2020.0 ORG LETT published article about HIGHLY SUBSTITUTED PYRIDINES; THIYL-RADICAL CATALYST; ONE-POT SYNTHESIS; VINYL AZIRIDINES; STEREOSELECTIVE-SYNTHESIS; SYMMETRICAL PYRIDINES; KETOXIME ACETATES; RECENT PROGRESS; OXIME ACETATES; CYCLIZATION in [Liu, Yantao; Wang, Zhenjie; Zhao, Yuxin; Zhao, Jingjing; Xu, Xuejun; Li, Pan] Henan Univ, Coll Chem & Chem Engn, Inst Funct Organ Mol Engn, Kaifeng 475004, Peoples R China; [Luo, Wen; Wang, Chaojie; Li, Pan] Henan Univ, Key Lab Nat Med & Immunoengn, Kaifeng 475004, Peoples R China in 2020.0, Cited 85.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

A visible-light photoredox-catalyzed formal [5 + 1] cycloaddition of N-tosyl vinylaziridines with difluoroalkyl halides as unique C1 synthons was developed. The procedure provides an efficient and practical method to synthesize diverse pyridines in moderate to good yields. The reaction underwent a radical-initiated kinetically controlled ring-opening of vinylaziridines and involved a key alpha,beta-unsaturated imine intermediate, followed by an E2 elimination, a 6 pi electrocyclization, and defluorinated aromatization.

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Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Formula: C15H12O. In 2020.0 ACTA POL PHARM published article about BIOLOGICAL EVALUATION; CELL-DEATH; MOLECULAR-MECHANISMS; CISPLATIN; FLAVOKAWAIN; DERIVATIVES; INHIBITION; ACTIVATION; APOPTOSIS; THERAPY in [Lukovic, Jovan; Mitrovic, Marina M.; Stanojevic-Pirkovic, Marijana; Andelkovic, Marija; Zelen, Ivanka; Nikolic, Ivana Sinisa] Univ Kragujevac, Fac Med Sci, Dept Biochem, Kragujevac, Serbia; [Popovic, Suzana] Univ Kragujevac, Fac Med Sci, Ctr Mol Med & Stem Cell Res, Dept Microbiol & Immunol, Kragujevac, Serbia; [Milosavljevic, Zoran] Univ Kragujevac, Fac Med Sci, Dept Histol & Embryol, Kragujevac, Serbia; [Sorak, Marija] Univ Kragujevac, Fac Med Sci, Dept Gynecol & Obstet, Kragujevac, Serbia; [Muskinja, Jovana; Ratkovic, Zoran] Univ Kragujevac, Fac Sci, Dept Chem, Radoja Domanovica 12,POB 60, Kragujevac 34000, Serbia in 2020.0, Cited 41.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Chalcones, as a large group of organic compounds, are widely implemented in various types of anticancer therapeutics. These plant metabolites are present in fruits, vegetables, spices, and have anti-tumor, anti-inflammation, immunomodulation, antibacterial and anti-oxidative activities, as well as many other pharmacological and biological effects. The aim of the present study was to investigate cytotoxic effects, type of cell death and mechanism of action of the newly synthesized vanillin based chalcone analogs, (CH1) and (CH2) on human colon cancer HCT-116 and noncancerous (control) MRC-5 cell lines. In order to compare the effects of vanillin based chalcone analogs on investigated cell lines, as reference substances cisplatin (cisPt) and dehydrozingerone (DHZ) were used. Investigation of antitumor effect of chalcone analogs on HCT-116 cells was carried out by three methods MTT assay, flow cytometry and immunofluorescence analysis. The result of our investigation indicated that newly synthesized vanillin based chalcone analogs expressed powerful antitumor effect on cancer cells (HCT-116 cell line), while their effect on healthy cells (MRC-5 cell line) was not statistically significant. Vanillin based chalcone analogs caused overexpression and activation of mitochondrial Bax protein and caspase-3 in HCT-116 cells, indicating that their mechanism of antitumor action was mediated through activation of the inner apoptotic pathway. These results indicate possible usefulness of CH1 and CH2 in antitumor therapy whether through its direct cytotoxic effect or as adjuvant therapy. Our results indicate possible usefulness of CH1 and CH2 vanillin based chalcone analogs in antitumor therapy.

Welcome to talk about 94-41-7, If you have any questions, you can contact Lukovic, J; Mitrovic, MM; Popovic, S; Milosavljevic, Z; Stanojevic-Pirkovic, M; Andelkovic, M; Zelen, I; Sorak, M; Muskinja, J; Ratkovic, Z; Nikolic, IS or send Email.. Formula: C15H12O

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com