Category: 94-41-7

I found the field of Chemistry very interesting. Saw the article Diastereoselective sulfonate-directed carbonyl reduction of gamma-keto-sulfonates published in 2019.0. Product Details of 94-41-7, Reprint Addresses Adamo, MFA (corresponding author), Royal Coll Surgeons Ireland, Dept Pharmaceut & Med Chem, CSCB, 123 St Stephens Green, Dublin 2, Ireland.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

The diastereoselective reduction of gamma-keto-sulfonates to afford alpha,gamma-substituted gamma-hydroxy sulfonates has been investigated. Herein we report the first example of a diastereoselective carbonyl reduction whereby hydride attack is directed via chelation of a neighbouring sulfonate group to a boron atom, thus affording prevalently trans gamma-hydroxy sulfonates. (C) 2019 Published by Elsevier Ltd.

Product Details of 94-41-7. About Chalcone, If you have any questions, you can contact McLaughlin, N; Duffy, C; Alletto, F; Ravelli, A; Lancianesi, S; Gillick-Healy, M; Adamo, MFA or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Lin, YM; Bu, QX; Xu, JX; Liu, X; Zhang, XP; Lu, GP; Zhou, BJ in [Lin, Yamei; Bu, Qingxia; Xu, Jiaxian; Liu, Xiao; Zhang, Xueping; Lu, Guo-Ping; Zhou, Baojing] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China; [Lin, Yamei] Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210032, Peoples R China published Hf-MOF catalyzed Meerwein-Ponndorf-Verley (MPV) reduction reaction: Insight into reaction mechanism in 2021.0, Cited 46.0. Name: Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Hf-MOF-808 exhibits excellent activity and specific selectivity on the hydrogenation of carbonyl compounds via a hydrogen transfer strategy. Its superior activity than other Hf-MOFs is attributed to its poor crystallinity, defects and large specific surface area, thereby containing more Lewis acid-base sites which promote this reaction. Density functional theory (DFT) computations are performed to explore the catalytic mechanism. The results indicate that alcohol and ketone fill the defects of Hf-MOF to form a six-membered ring transition state (TS) complex, in which Hf as the center of Lewis stearic acid coordinates with the oxygen of the substrate molecule, thus effectively promoting hydrogen transfer process. Other reactive groups, such as ?NO2, C = C, -CN, of inadequate hardness or large steric hindrance are difficult to coordinate with Hf, thus weakening their catalytic effect, which explains the specific selectivity Hf-MOF-808 for reducing the carbonyl group.

Name: Chalcone. About Chalcone, If you have any questions, you can contact Lin, YM; Bu, QX; Xu, JX; Liu, X; Zhang, XP; Lu, GP; Zhou, BJ or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Khalil, KD; Riyadh, SM; Gomha, SM; Ali, I in ELSEVIER SCIENCE BV published article about NANOPARTICLES; N-2-ARYL-SUBSTITUTED-1,2,3-TRIAZOLES; PYRIMIDINE; CHALCONES; CATALYST; COMPLEX; HPLC in [Khalil, Khaled D.] Taibah Univ, Dept Chem, Fac Sci, Yanbu 46423, Saudi Arabia; [Riyadh, Sayed M.; Ali, Imran] Taibah Univ, Dept Chem, Fac Sci, Al Madinah Al Munawarah 30002, Saudi Arabia; [Khalil, Khaled D.; Riyadh, Sayed M.; Gomha, Sobhi M.] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt; [Gomha, Sobhi M.] Islamic Univ Almadinah Almonawara, Fac Sci, Dept Chem, Almadinah Almonawara 42351, Saudi Arabia; [Ali, Imran] Cent Univ, Jamia Millia Islamia, Dept Chem, New Delhi, India in 2019.0, Cited 44.0. Quality Control of Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Chitosan copper (II) oxide nanocomposite was synthesized, characterized and used to synthesize [1,2,3] triazoles. Nanocomposite was characterized by using FTIR, XRD, FESEM, and EDS techniques, which reflected rough morphology. The powerful catalytic activity of hybrid nanocomposite was utilized to synthesize chalcones (3a-p) in relatively high yields (82%-98%) and multicomponent regio-selective cycloaddition of chalones, aryl halides (4), and sodium azide to afford the expected N-2-aryl[1,2,3]triazoles (5a-h) (80%-95% yield) rather than N-1-aryl(1,2,3]-triazoles (6a-h). The performance of nanomaterial was optimized by several variables. The capability of the nanocomposite was compared with previous work and the nanocomposite was found more efficient, economic and reproducible. The hybrid nanocomposite could be easily isolated form the reaction mixture and recycled four times without any significant loss of its catalytic activity. The reported catalyst is an inexpensive for good yields of the triazoles and may be used at industrial production for the reported compounds. (C) 2019 Published by Elsevier B.V.

Quality Control of Chalcone. About Chalcone, If you have any questions, you can contact Khalil, KD; Riyadh, SM; Gomha, SM; Ali, I or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

COA of Formula: C15H12O. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article BA-12 Inhibits Angiogenesis via Glutathione Metabolism Activation published in 2019.0, Reprint Addresses Xu, B; Wang, PL; Lei, HM (corresponding author), Beijing Univ Chinese Med, Sch Chinese Pharm, Beijing 102488, Peoples R China.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone.

There is a need for an efficient and low-cost leading compound discovery mode. However, drug development remains slow, expensive, and risky. Here, this manuscript proposes a leading compound discovery strategy based on a combination of traditional Chinese medicine (TCM) formulae and pharmacochemistry, using a ligustrazine-betulinic acid derivative (BA-12) in the treatment of angiogenesis as an example. Blocking angiogenesis to inhibit the growth and metastasis of solid tumors is currently one recognized therapy for cancer in the clinic. Firstly, based on a traditional Prunella vulgaris plaster, BA-12 was synthesized according to our previous study, as it exhibited better antitumor activities than other derivatives on human bladder carcinoma cells (T24); it was then uploaded for target prediction. Secondly, the efficacy and biotoxicity of BA-12 on angiogenesis were evaluated using human umbilical vein endothelial cells (HUVECs), a quail chick chorioallantoic membrane, and Caenorhabditis elegans. According to the prediction results, the main mechanisms of BA-12 were metabolic pathways. Thus, multiple metabolomics approaches were applied to reveal the mechanisms of BA-12. Finally, the predictive mechanisms of BA-12 on glutathione metabolism and glycerophospholipid metabolism activation were validated using targeted metabolomics and pharmacological assays. This strategy may provide a reference for highly efficient drug discovery, with the aim of sharing TCM wisdom for unmet clinical needs.

About Chalcone, If you have any questions, you can contact Cui, HR; Guo, WB; Zhang, BB; Li, GP; Li, T; Yuan, YY; Zhang, N; Yang, YW; Feng, WW; Chu, FH; Wang, SL; Xu, B; Wang, PL; Lei, HM or concate me.. COA of Formula: C15H12O

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Rh-catalyzed 1,4-addition reactions of arylboronic acids accelerated by co-immobilized tertiary amine in silica mesopores WOS:000472687900001 published article about HETEROGENEOUS SYNERGISTIC CATALYSIS; BOND-FORMING REACTIONS; TSUJI-TROST REACTION; ASYMMETRIC 1,4-ADDITION; COOPERATIVE CATALYSIS; CONJUGATE ADDITION; PHENYLBORONIC ACID; PALLADIUM COMPLEX; BISPHOSPHINE COMPLEX; SUPPORTED CATALYSTS in [Motokura, Ken; Hashiguchi, Kohei; Maeda, Kyogo; Nambo, Masayuki; Manaka, Yuichi] Tokyo Inst Technol, Sch Mat & Chem Technol, Dept Chem Sci & Engn, Midori Ku, 4259 Nagatsuta Cho, Yokohama, Kanagawa 2268502, Japan; [Motokura, Ken] Japan Sci & Technol Agcy JST, PRESTO, Saitama 3320012, Japan; [Manaka, Yuichi] Natl Inst Adv Ind Sci & Technol, Renewable Energy Res Ctr, 2-2-9 Machiikedai, Koriyama, Fukushima 9630298, Japan; [Chun, Wang-Jae] Int Christian Univ, Grad Sch Arts & Sci, Mitaka, Tokyo 1818585, Japan in 2019.0, Cited 65.0. Safety of Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Mesoporous silica-supported Rh complex catalysts were prepared by simple silane-coupling, followed by cornplexation, and characterized by FT-IR, SEM, Rh K-edge XAFS, and elemental analysis. Local structures of the Rh complexes in each sample were almost similar to those of a nonporous silica-supported diaminorhodiurn complex. Co-immobilization of a tertiary amine on the same silica surface induced slight changes to the Rh complex structure in the case of the support with smaller pores. The prepared catalysts showed high activity for the 1,4 addition reaction of phenylboronic acids. Co-immobilization of the tertiary amine increased the reaction rate by more than 7-fold, with turnover number of nearly 8500. The catalytic performance achieved with this novel system is with much higher than that reported previously with a nonporous silica-supported catalyst. The mesoporous silica-supported Rh complex-tertiary amine showed a wide substrate scope, including unsaturated ketones and nitriles. This co-immobilized tertiary amine may activate phenylboronic acid to enhance its reactivity in the transmetalation step with Rh-OH species.

About Chalcone, If you have any questions, you can contact Motokura, K; Hashiguchi, K; Maeda, K; Nambo, M; Manaka, Y; Chun, WJ or concate me.. Safety of Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Computed Properties of C15H12O. Sanad, SMH; Mekky, AEM in [Sanad, Sherif M. H.; Mekky, Ahmed E. M.] Cairo Univ, Fac Sci, Chem Dept, Giza 12613, Egypt published Novel nicotinonitrile-coumarin hybrids as potential acetylcholinesterase inhibitors: design, synthesis, in vitro and in silico studies in 2021.0, Cited 59.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Alzheimer’s disease is a degenerative brain condition that is the leading cause of dementia affecting millions of people around the world. Therapeutic development has focused on the problem of the loss of basal forebrain cholinergic function, as it is the only evidence responsible for brain neurodegeneration in patients with Alzheimer’s disease. Several attempts to improve cholinergic neurotransmission have been investigated by minimizing synaptic degradation of acetylcholine using acetylcholinesterase inhibitors. In the current study, we explore the designing of a new series of nicotinonitrile-coumarin hybrids as potential acetylcholinesterase inhibitors. The new hybrids were prepared utilizing pyridine-2(1H)-thiones as starting precursors. The in vitro acetylcholinesterase (AChE) inhibitory activities were examined for the new nicotinonitrile-coumarin hybrid molecules, when compared with donepezil as a standard drug with IC(50)of 14 nM. Coumarin derivative, linked to 6-(4-nitrophenyl)-4-phenylnicotinonitrile, showed more effective inhibitory activity than the reference donepezil with IC(50)of 13 nM. The free radical-scavenging capabilities against DPPH of the new hybrid derivatives were screened. Additionally, their in vitro cytotoxic activities have been tested against various eukaryotic cells. Furthermore, docking study showed excellent interaction between nicotinonitrile-coumarin hybrids and AChE. [GRAPHICS] .

Computed Properties of C15H12O. About Chalcone, If you have any questions, you can contact Sanad, SMH; Mekky, AEM or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article A highly efficient Hg(OTf)(2)-mediated Sakurai-Hosomi allylation of N-tert-butyloxycarbonylamino sulfones, aldehydes, fluoroalkyl ketones and alpha,beta-unsaturated enones using allyltrimethylsilane WOS:000501342100012 published article about CATALYTIC ENANTIOSELECTIVE ADDITION; ASYMMETRIC ALLYLATION; MEDIATED CYCLIZATION; CONJUGATE ALLYLATION; HOMOALLYLIC AMINES; AROMATIC-ALDEHYDES; CARBONYL-COMPOUNDS; GALLIUM CHLORIDE; ALLYLSILANES; MERCURY in [Gong, Yi; Zhou, Ying; Zhou, Jian] Guiyang Univ Chinese Med, Coll Pharm, Guiyang 550025, Guizhou, Peoples R China; [Cao, Zhong-Yan; Zhou, Feng; Zhou, Jian] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, 3663N Zhongshan Rd, Shanghai 200062, Peoples R China; [Cao, Zhong-Yan] Zhejiang Univ Technol, Coll Chem Engn, Chaowang Rd 18, Hangzhou 310014, Zhejiang, Peoples R China; [Shi, Ying-Bo] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610066, Sichuan, Peoples R China; [Zhou, Jian] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China in 2019.0, Cited 86.0. COA of Formula: C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

It is reported that cheap and easily available Hg(OTf)(2) can efficiently mediate the Sakurai-Hosomi reaction of N-tert-butyloxycarbonyl (Boc) amino sulfones, aldehydes, and alpha-fluoroalkyl ketones using allyltrimethylsilane, with the catalyst loading down to 0.5-5.0 mol%, enabling the facile access to synthetically valuable homoallylic alcohols or amines, respectively. A chemoselective 1,4-allylation of alpha,beta-unsaturated enones is also achieved under the catalysis of 5.0 mol% Hg(OTf)(2). In most cases, Hg(OTf)(2) exhibited intriguing properties superior to those of commonly used metal Lewis acids for such reactions, suggesting that mercury catalysis is worthwhile to explore.

About Chalcone, If you have any questions, you can contact Gong, Y; Cao, ZY; Shi, YB; Zhou, F; Zhou, Y; Zhou, J or concate me.. COA of Formula: C15H12O

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Asymmetric synthesis of highly functionalized furanones via direct Michael reactions mediated by a bulky primary amine WOS:000465285100029 published article about TETRONIC ACID-DERIVATIVES; ALPHA,BETA-UNSATURATED KETONES; CONJUGATE ADDITION; BETA-KETOCARBONYLS; ALKYLATION; 3(2H)-FURANONES; CONSTRUCTION; QUATERNARY; CATALYSIS; ALDEHYDES in [Huang, Huicai; Lu, Xue; Mao, Yukang] Guangzhou Univ Chinese Med, Res Ctr Chinese Herbal Resource Sci & Engn, Guangzhou 510006, Guangdong, Peoples R China; [Huang, Huicai; Lu, Xue; Mao, Yukang] Guangzhou Univ Chinese Med, Key Lab Chinese Med Resource Lingnan, Minist Educ, Guangzhou 510006, Guangdong, Peoples R China; [Ye, Jinxing] East China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China in 2019.0, Cited 61.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Category: thiazolidines

The asymmetric Michael reaction of 3(2H) furanones and alpha, beta-unsaturated ketones was investigated, with the employment of a bulky chiral primary amine. The protocol afforded a series of substituted furanone derivatives in a highly diastereo-(> 30 : 1 dr) and enantioselective (up to 93% ee) manner with generally good to excellent yields (up to 99%).

About Chalcone, If you have any questions, you can contact Huang, HC; Lu, X; Mao, YK; Ye, JX or concate me.. Category: thiazolidines

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Formula: C15H12O. In 2020.0 ANGEW CHEM INT EDIT published article about AGGREGATION-INDUCED EMISSION; WHITE-LIGHT EMISSION; PIEZOCHROMIC LUMINESCENCE; MOLECULAR AGGREGATION; LIQUID-CRYSTALS; HIGH-EFFICIENCY; COLOR CHANGES; PHOTOLUMINESCENT; EMITTERS; ELECTROLUMINESCENCE in [Yang, Minlang; Park, In Seob; Yasuda, Takuma] Kyushu Univ, INAMORI Frontier Res Ctr IFRC, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan; [Yang, Minlang; Yasuda, Takuma] Kyushu Univ, Grad Sch Engn, Dept Appl Chem, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan; [Miyashita, Yasuhiro; Tanaka, Katsunori] Nippon Soda Co Ltd, Odawara Res Ctr, 345 Takada, Odawara, Kanagawa 2500280, Japan in 2020.0, Cited 82.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Herein, the universal design of high-efficiency stimuli-responsive luminous materials endowed with mechanochromic luminescence (MCL) and thermally activated delayed fluorescence (TADF) functions is reported. The origin of the unique stimuli-triggered TADF switching for a series of carbazole-isophthalonitrile-based donor-acceptor (D-A) luminogens is demonstrated based on systematic photophysical and X-ray analysis, coupled with theoretical calculations. It was revealed that a tiny alteration of the intramolecular D-A twisting in the excited-state structures governed by the solid morphologies is responsible for this dynamic TADF switching behavior. This concept is applicable to the fabrication of bicolor emissive organic light-emitting diodes using a single TADF emitter.

About Chalcone, If you have any questions, you can contact Yang, ML; Park, IS; Miyashita, Y; Tanaka, K; Yasuda, T or concate me.. Formula: C15H12O

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Application In Synthesis of Chalcone. Xu, YM; Chen, XQ; Gao, YQ; Yan, ZC; Wan, CF; Liu, JB; Wang, ZY in [Xu, Yumin; Chen, Xiaoqian; Gao, Yiqin; Wan, Changfeng; Liu, Jin-Biao] Jiangxi Normal Univ, Coll Chem & Chem Engn, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China; [Xu, Yumin; Chen, Xiaoqian; Gao, Yiqin; Wan, Changfeng; Liu, Jin-Biao] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China; [Liu, Jin-Biao] Jiangxi Univ Sci & Technol, Sch Met & Chem Engn, Ganzhou 341000, Peoples R China; [Yan, Zicong; Wang, Zhiyong] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China published Synthesis of Trifluoromethyl- and Ester Group-Substituted alpha-Carbolines via Iron-Catalyzed Tandem Cyclization Reaction in 2020.0, Cited 47.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

An efficient approach to prepare trifluoromethyl-alpha-carbolines and ester group-substituted alpha-carbolines via the tandem cyclization reaction of 2-(2-aminophenyl)acetonitriles and trifluoromethyl 1,3-diones or beta,gamma-unsaturated alpha-ketoesters was reported. The transformation proceeded smoothly in the presence of catalytic environmental-benign iron salts, which are used to prepare the desired products in moderate to good yields.

Application In Synthesis of Chalcone. About Chalcone, If you have any questions, you can contact Xu, YM; Chen, XQ; Gao, YQ; Yan, ZC; Wan, CF; Liu, JB; Wang, ZY or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com