Category: 94-41-7

Recently I am researching about ASYMMETRIC TRANSFER HYDROGENATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21962004, 21562004]; Jiangxi Provincial Department of Science and Technology [20192BAB203004]; Fundamental Research Funds for Gannan Medical University [QD201810]; COVID-19 Emergency Project of Gannan Medical University [YJ202027]. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Xia, YP; Ouyang, L; Liao, JH; Yang, X; Luo, RS. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone. Quality Control of Chalcone

Efficient chemoselective transfer hydrogenation of the C=C bond of alpha,beta-unsaturated ketones has been developed, using the iridium complexes containing pyridine-imidazolidinyl ligands as catalysts and formic acid as a hydrogen source. In comparison with organic solvents or H2O as solvent, the mixed solvents of H2O and MeOH are critical for a high catalytic chemoselective transformation. This chemoselective transfer hydrogenation can be carried out in air, which is operationally simple, allowing a wide variety of alpha,beta-unsaturated substrates with different functional groups (electron-donating and electron-withdrawing substituents) leading to chemoselective transfer hydrogenation in excellent yields. The practical application of this protocol is demonstrated by a gram-scale transformation.

Quality Control of Chalcone. About Chalcone, If you have any questions, you can contact Xia, YP; Ouyang, L; Liao, JH; Yang, X; Luo, RS or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Safety of Chalcone. In 2019.0 MED CHEM published article about 1(2H)-PHTHALAZINONE DERIVATIVES; E2020 ARICEPT(R); ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; TOXICITY; BINDING; AGENTS; SITE in [Kilic, Burcu; Erdogan, Merve; Dogruer, Deniz S.] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkey; [Gulcan, Hayrettin O.] Eastern Mediterranean Univ, Fac Pharm, Dept Pharmaceut Chem, Gazimagosa, North Cyprus, Turkey; [Aksakarl, Fatma] Hacettepe Univ, Dept Chem, Ankara, Turkey; [Oruklu, Nihan; Bagriacik, Emin U.] Gazi Univ, Fac Med, Dept Immunol, Ankara, Turkey in 2019.0, Cited 36.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Background: With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to the population over the age of 65 during the past several decades. The majority of AD treatments are focused on cholinergic and amyloid hypotheses. Objective: In this study, three series of diphenyl-2-(2-(4-substitutedpiperazin-l-yl)ethyl)pyridazin-3(2H)-one derivatives were designed, synthesized and investigated for their ability to inhibit both cholinesterase enzymes and amyloid-beta aggregation. Method: The inhibitory activities of the synthesized compounds on AChE (from electric eel) and BChE (from equine serum) were determined by the modified Ellman’s method. The reported thioflavin T-based fluorometric assay was performed to investigate the effect of the selected compounds on the aggregation of A beta(1-42). The cytotoxic effect of the compounds (4g, 11g and 18g) was monitored in 3T3 cell lines to gain insight into therapeutic potential of the compounds by using MTT assay. The crystal structures of the AChE (1EVE) and BChE (1POI) enzymes were retrieved from the RCSB Protein Data Bank and Molecular Operating Environment (MOE) software was used for molecular docking of the ligands. Results: Among the tested compounds, 5,6-diphenyl derivative 18g was identified as the most potent and selective AChE inhibitor (IC50 = 1.75 mu M, Selectivity Index for AChE > 22.857). 4,6-Diphenyl derivative 11g showed the highest and the most selectivity for BChE (IC50= 4.97 mu M, SI for AChE < 0.124). Interestingly, 4,5-diphenyl derivative 4g presented dual cholinesterase inhibition (AChE IC50= 5.11 mu M; BChE IC50= 14.16 mu M, SI for AChE = 2.771). Conclusion: Based on biological activity results and low toxicity of the compounds, it can be said that diphenyl substituted pyridazinone core is a valuable scaffold. Especially, dual inhibitory potencies of 4,5-diphenylpyridazin-3(2H)-one core for the cholinesterase enzymes and A beta-aggregation makes this core a promising disease-modifying agent. Safety of Chalcone. About Chalcone, If you have any questions, you can contact Kilic, B; Erdogan, M; Gulcan, HO; Aksakarl, F; Oruklu, N; Bagriacik, EU; Dogruer, DS or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Wang, YY; Du, ZY; Zheng, TT; Sun, HJ; Li, XY in ELSEVIER SCIENCE BV published article about ASYMMETRIC TRANSFER HYDROGENATION; KETONES; REDUCTION in [Wang, Yangyang; Du, Zhengyin] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China; [Wang, Yangyang; Zheng, Tingting; Sun, Hongjian; Li, Xiaoyan] Shandong Univ, Minist Educ, Key Lab Special Funct Aggregated Mat, Sch Chem & Chem Engn, Shanda Nanlu 27, Jinan 250100, Shandong, Peoples R China; [Zheng, Tingting] Capital Normal Univ, Dept Chem, Beijing 100037, Peoples R China in 2019.0, Cited 19.0. Formula: C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Selenophenolato hydrido iron(II) complexes 1-3 cis-[(H)(SeAr)Fe(PMe3)(4)] (Ar = C6H5 (1), p-MeOC6H4 (2) and o-MeC6H4 (3)) could catalyze transfer hydrogenation of aldehydes and ketones. Among the three complexes, catalyst 1 exhibited the highest catalytic activity. The catalytic reactions took place under very mild conditions, using isopropanol as solvent and hydrogen source, (BuONa)-Bu-t as base under 60-80 degrees C. This catalytic system has good tolerance for many functional groups, such as halides, C=C double bonds, nitro groups and cyano groups at the phenyl ring of the substrates.

Formula: C15H12O. About Chalcone, If you have any questions, you can contact Wang, YY; Du, ZY; Zheng, TT; Sun, HJ; Li, XY or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recently I am researching about CYCLOADDITION REACTIONS; AZOMETHINE YLIDES; ROUTE, Saw an article supported by the Science Foundation for Distinguished Scholars of Dongguan University of Technology [GC200906-10, G200906-44]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51773165]; Young Talent Support Plan of Xi’an Jiaotong University. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Wang, Q; Yuan, T; Liu, Q; Xu, Y; Xie, GQ; Lv, X; Ding, SJ; Wang, XX; Li, C. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone. Product Details of 94-41-7

Here, we describe an efficient and environmentally friendly synthesis of polycyclic N-heterocycles under electrochemical external oxidant-free conditions. The extent of the sequential electrochemical oxidative aromatization can be regulated with the assistance of redox mediators.

About Chalcone, If you have any questions, you can contact Wang, Q; Yuan, T; Liu, Q; Xu, Y; Xie, GQ; Lv, X; Ding, SJ; Wang, XX; Li, C or concate me.. Product Details of 94-41-7

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In 2021.0 CHEM SCI published article about ENANTIOSELECTIVE HYDROGENATION; QUINOXALINES; DISCOVERY; INHIBITORS; REDUCTION; EFFICIENT; LIGANDS; ROUTE; CETP in [Huang, Jin; Li, Guang-xun; Yang, Gao-feng; Fu, Ding-qiang; Nie, Xiao-kang; Cui, Xin; Tang, Zhuo] Chinese Acad Sci, Nat Prod Res Ctr, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China; [Huang, Jin] Univ Chinese Acad Sci, Beijing, Peoples R China; [Zhao, Jin-zhong] Shanxi Agr Univ, Coll Art & Sci, Taigu 030800, Shanxi, Peoples R China in 2021.0, Cited 40.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Product Details of 94-41-7

N-Substituted tetrahydroquinoxalines (37 examples) were step-economically obtained in good yield (<97%) and ee (<99%) with readily available substrates. The reaction proceeds through an interesting regioselective Heyns rearrangement/enantioselective transfer hydrogenation in one pot. The substrate scope and the reaction mechanism were systematically investigated. About Chalcone, If you have any questions, you can contact Huang, J; Li, GX; Yang, GF; Fu, DQ; Nie, XK; Cui, X; Zhao, JZ; Tang, Z or concate me.. Product Details of 94-41-7

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Name: Chalcone. Recently I am researching about BORANE REDUCTION; ALPHA,BETA-UNSATURATED KETONES; ENANTIOSELECTIVE ADDITION; POLYETHERS; RECOGNITION; COMPLEXES; CATALYSTS; ESTERS, Saw an article supported by the General Project of the Education Department of Hunan Province, China [17C1524]; Foundation for Young Scholars of Xiangtan University of Science & Technology, China [15QDZ52]. Published in HIGHER EDUCATION PRESS in BEIJING ,Authors: Liu, F; Li, QF; Ouyang, KB; Yang, NF. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

Two chiral polymers based on binaphthol(BINOL) were synthesized. The polymer can be used as a chiral inducer to coordinate with ZnEt2 to form a recoverable self-supporting catalyst, which could be used in the asymmetric catalytic reaction of alpha, beta-unsaturated ketones. The target products of high yield and good enantioselectivity(e.e. value up to 99%) can be obtained under mild conditions. The catalytic activity was not reduced significantly after 4 or 5 cycles of recovery of the recovered polymers.

About Chalcone, If you have any questions, you can contact Liu, F; Li, QF; Ouyang, KB; Yang, NF or concate me.. Name: Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Guo, T; Xia, ROJ; Chen, M; He, J; Su, SJ; Liu, LW; Li, XY; Xue, W in [Guo, Tao; Xia, Ronqjiao; Chen, Mei; He, Jun; Su, Shijun; Liu, Liwei; Li, Xiangyang; Xue, Wei] Guizhou Univ, Ctr Res & Dev Fine Chem, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,State Key Lab Breeding Base Green Pes, Guiyang 550025, Guizhou, Peoples R China published Biological activity evaluation and action mechanism of chalcone derivatives containing thiophene sulfonate in 2019.0, Cited 51.0. SDS of cas: 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

A series of novel chalcone derivatives containing a thiophene sulfonate group were designed and synthesized. The structures of all title compounds were determined by H-1-NMR, C-13-NMR and HRMS. Antibacterial bioassays indicated that, compound 2l demonstrated excellent antibacterial activities against Xanthomonas axonopodis pv. citri (Xac), with an EC50 value of 11.4 mu g mL(-1), which is significantly superior to those of bismerthiazol (BT) (51.6 mu g mL(-1)) and thiodiazole-copper (TC) (94.7 mu g mL(-1)). Meanwhile, the mechanism of action of compound 2l was confirmed by using scanning electron microscopy (SEM). In addition, compound 2e showed remarkable inactivation activity against Tobacco mosaic virus (TMV), with an EC50 value of 44.3 mu g mL(-1), which was superior to that of ningnanmycin (120.6 mu g mL(-1)). Microscale thermophoresis (MST) also showed that the binding of compounds 2e and 2h to Tobacco mosaic virus coat protein (TMV-CP) yielded K-d values of 0.270 and 0.301 mu mol L-1, which are better than that of ningnanmycin (0.596 mu mol L-1). At the same time, molecular docking studies for 2e and 2h with TMV-CP (PDB code: ; 1EI7) showed that the compound was embedded well in the pocket between the two subunits of TMV-CP in each case. These results suggested that chalcone derivatives containing a thiophene sulfonate group may be considered as activators in the design of antibacterial and antiviral agents.

SDS of cas: 94-41-7. About Chalcone, If you have any questions, you can contact Guo, T; Xia, ROJ; Chen, M; He, J; Su, SJ; Liu, LW; Li, XY; Xue, W or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Acyl Radicals from alpha-Keto Acids Using a Carbonyl Photocatalyst: Photoredox-Catalyzed Synthesis of Ketones WOS:000569377600028 published article about C-H BONDS; OXOCARBOXYLIC ACIDS; MERGING PHOTOREDOX; ELECTRON-TRANSFER; CARBOXYLIC-ACIDS; ARYL HALIDES; LIGHT; METAL; ACYLATION; ALKENES in [Zhu, Da-Liang; Wu, Qi; Wang, Hao; Ren, Zhi-Gang; Li, Hong-Xi] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China; [Young, David James] Charles Darwin Univ, Coll Engn Informat Technol & Environm, Darwin, NT 0909, Australia in 2020.0, Cited 65.0. Computed Properties of C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Acyl radicals have been generated from alpha-keto acids using inexpensive and commercially available 2-chloro-thioxanthen-9-one as the photoredox catalyst under visible light illumination. These reactive species added to olefins or coupled with aryl halides via a bipyridyl-stabilized Ni(II) catalyst, enabling easy access to a diverse range of ketones. This reliable, atom-economical, and eco-friendly protocol is compatible with a wide range of functional groups.

Computed Properties of C15H12O. About Chalcone, If you have any questions, you can contact Zhu, DL; Wu, Q; Young, DJ; Wang, H; Ren, ZG; Li, HX or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Pilkington, LI; Yang, X; Liu, MW; Hemar, Y; Brimble, MA; Reynisson, J in [Pilkington, Lisa I.; Yang, Xue; Liu, Meng-Wen; Hemar, Yacine; Brimble, Margaret A.; Reynisson, Johannes] Univ Auckland, Sch Chem Sci, Private Bag 92019, Auckland 1142, New Zealand published A Chemometric Analysis of Compounds from Native New Zealand Medicinal Flora in 2019.0, Cited 40.0. Product Details of 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Several hundred (396) compounds from New Zealand flora with medicinal properties were analyzed for their physicochemical properties. It was found that approximately 10% fulfilled all the requirements to be considered to be lead-like, over half of the compounds were deemed to be in the drug-like space and approximate to 75% were in the known drug space. These results indicate the presence of a significant proportion of compounds that are of particular interest to pursue as potential lead compounds or therapeutics. Additionally, compound classes were analyzed separatelymost carbonyl-containing compounds (aldehydes, ketones, esters and lactones), along with phenols were the most lead-like compounds, which also displayed very good proportions in the drug-like and known drug space. The information presented herein can be harnessed and utilized in future work, through focussing on the compounds and compound classes that exhibit high-levels of lead-likeness for further development.

Product Details of 94-41-7. About Chalcone, If you have any questions, you can contact Pilkington, LI; Yang, X; Liu, MW; Hemar, Y; Brimble, MA; Reynisson, J or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recently I am researching about BIOLOGICAL EVALUATION, Saw an article supported by the Council of Scientific and Industrial Research (CSIR), New Delhi, IndiaCouncil of Scientific & Industrial Research (CSIR) – India [DST-SERB/EEQ/2017/095]. HPLC of Formula: C15H12O. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Vanaparthi, S; Bantu, R; Jain, N; Janardhan, S; Nagarapu, L. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

A new series of 1,2,3-triazole tethered chalcone acetamide derivatives (7a-c & 8a-r) have been synthesized in excellent yields and their structures were determined by analytical and spectral (FT-IR, H-1 NMR, C-13 NMR HRMS) studies. The newly synthesized derivatives were evaluated for their cytotoxic activity against four human cancer cell lines, such as HeLa (Human cervical cancer), A549 (Human alveolar adenocarcinoma), MCF-7 (Human breast adenocarcinoma) and SKNSH (Human brain cancer). Among them, compound 7c exhibited good anti-proliferation activity with HeLa (IC50 7.41 + 0.8 mu M), SKNSH (IC50 8.68 + 1.1 mu M), MCF-7 (IC50 9.76 + 1.3 mu M) and MDA-MB-231, while compounds 7a and 7b showed promising anti-proliferation against above four human cancer cell lines with IC50 7.95-11.62 mu M, respectively, compared with the standard drug Doxorubicin. We explored the probable key active site and binding mode interactions in HDAC8 (PDB ID:3SFH) and EHMT2 (PDB ID:3K5K) proteins. The docking results are complementary to the experimental observations.

HPLC of Formula: C15H12O. About Chalcone, If you have any questions, you can contact Vanaparthi, S; Bantu, R; Jain, N; Janardhan, S; Nagarapu, L or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com