Category: thiazolidine

7025-19-6, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.7025-19-6, name is 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid, below Introduce a new synthetic route.

To a solution of 3-iodo-N-(3,4,5-trifluorophenyl)-4,5,6,7-tetrahydropyrazolo[l,5- a]pyridine-5-carboxamide (compound lh, 20 mg, 0.048 mmol) in DMSO (1.0 mL) was added Cul (2 mg, 0.0095 mmol), K2C03 (7 mg, 0.095 mmol), N,N’-dimethyl-l,2-cyclohexanediamine (2 mg, 0.0095 mmol), and 1,2-thiazolidine 1,1-dioxide (compound 5a, 5 mg, 0.057 mmol). The reaction mixture was stirred at 110 C for 18 hours and then purified by flash chromatography and prep-HPLC to give 3-(l,l-dioxo-l,2-thiazolidin-2-yl)-N-(3,4,5-trifluorophenyl)-4,5,6,7- tetrahydropyrazolo[l,5-a]pyridine-5-carboxamide (Example 5, 11.5 mg) as a white solid. 1H NMR (400MHz, CDC13) delta 8.21 (s, 1H), 7.56 (s, 1H), 7.41 – 7.26 (m, 2H), 4.27 – 4.14 (m, 1H), 4.07 (m, 1H), 3.73 – 3.54 (m, 2H), 3.36 (t, 2H), 3.25 – 3.08 (m, 2H), 2.84 – 2.72 (m, 1H), 2.60 – 2.39 (m, 3H), 2.34 – 2.21 (m, 1H). MS obsd. (ESI+) [(M+H)+]: 415

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 1,1-Dioxo-isothiazolidine, We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HU, Taishan; SHEN, Hong; HAN, Xingchun; (45 pag.)WO2018/11100; (2018); A1;,
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5908-62-3, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.5908-62-3, name is 1,1-Dioxo-isothiazolidine. An updated downstream synthesis route of 5908-62-3 as follows.

7025-19-6, General procedure: To a mixture of aldehyde (1.0 mmol), 3-(4-oxo-2-thioxothiazolidin-3-yl)propanoic acid (205 mg,1.0 mmol) or 3-(2-(1H-tetrazol-5-yl)ethyl)-2-thioxothiazolidin-4-one (229 mg, 1.0 mmol) and NaOAc (820 mg, 10.0 mmol) was added acetic acid (5.0 mL). The reaction was allowed to stir at 105 C for 0.5h – 12h, then cooled to room temperature. To the reaction was added water (15mL). The resulting mixture was sonicated to give yellow-orange slurry. After filtration, the solid was washed with water (75 mL) and dried under high vacuum to yield the corresponding product as a red fine powder.

In every case, we must determine the overall rate law from experimental data and deduce the mechanism from the rate law (and sometimes from other data). you can also browse my other articles about 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid if you are interested.

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Article; Liang, Dongdong; Robinson, Elizabeth; Hom, Kellie; Yu, Wenbo; Nguyen, Nam; Li, Yue; Zong, Qianshou; Wilks, Angela; Xue, Fengtian; Bioorganic and Medicinal Chemistry Letters; vol. 28; 6; (2018); p. 1024 – 1029;,
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Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.185137-29-5, name is (S)-4-Phenylthiazolidine-2-thione,below Introduce a new synthetic route., 185137-29-5

To a stirred solution of 3-bromo-9-fluoro-6-methanesulfonyl-5H-pyrido[3,2- bjindole (200 mg, 0.583 mmol) and isothiazolidine-l,l-dione (278 mg, 2.30 mmol) in NMP (2.40 mL) was added t-BuOK (203 mg, 1.81 mmol). This mixture was heated at 115 C for 11 h and cooled to room temperature. The mixture was diluted with EtOAc (20 mL) and 10% aq. LiCl solution (20 mL). Some insoluble solid was filtered to give the desired product, 2-(3-bromo-6-(methylsulfonyl)-5H-pyrido[3,2-b]indol-9- yl)isothiazolidine-l,l-dione (115 mg, 44%). NMR (400MHz, DMSO-de) delta 11.94 (br s, 1H), 8.72 (br s, 1H), 8.32 (br s, 1H), 8.04 (br d, J=7.6 Hz, 1H), 7.55 (br s, 1H), 4.22 (br s, 2H), 3.59 (br s, 2H), 3.39 (br s, 3H), 2.61 (br s, 2H). HPLC: RT=2.055 min (Chromolith ODS 4.6 x 50 mm (4 min grad) eluting with 10-90% aqueous MeOH over 4 min containing 0.1 % TFA, 4 mL/min, monitoring at 220 nm); MS (ES): m/z= 444,1 ; 445.9 (Br pattern) [M+H]+.

Any one of these steps may be slow and thus may serve as the rate determining step. In general, however, in the presence of the catalyst, the overall rate of the reaction is faster than it would be if the reactants were in the gas or liquid phase.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; HAN, Wen-Ching; DEGNAN, Andrew P.; DESKUS, Jeffrey A.; GAVAI, Ashvinikumar V.; GILL, Patrice; SCHMITZ, William D.; STARRETT, John E., Jr.; (193 pag.)WO2016/183115; (2016); A1;,
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A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.26364-65-8, name is 2-Cyanoimino-1,3-thiazolidine. An updated downstream synthesis route of 26364-65-8 as follows., 26364-65-8

General procedure: To thiazolidine-2-thiones (1.0 equiv.) in THF (5.5 mL/mmol), 60% NaH dispersion in mineral oil (1.2 equiv.)was slowly added at 0 C. The reaction mixture was stirred for 15 min at 0 C before acetyl chloride (1.2 equiv.)was added dropwise. The reaction mixture was stirred for 30 min at 0 C, upon which it was warmed to roomtemperature and allowed to stir for another 2 h. The reaction was quenched with saturated NH4Cl (3 mL/mmol)and the layers were separated. The aq. layer was extracted with EtOAc (2 x 4 mL/mmol) and the combinedorganic layers were dried (Na2SO4),filtered, and concentrated in vacuo. The crude product was purified bycolumn chromatography on silica (hexanes/EtOAc 8:2) to afford the title compounds as yellow oils.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 185137-29-5

Reference£º
Article; Tungen, J¡ãrn E.; Aursnes, Marius; Hansen, Trond Vidar; Tetrahedron Letters; vol. 56; 14; (2015); p. 1843 – 1846;,
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Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.2682-49-7, name is Thiazolidin-2-one,below Introduce a new synthetic route., 2682-49-7

General procedure: Thiazolidin-2-ylidene-cyanamide (0.317 g, 2.50 mmol) inacetonitrile (20 mL) was dropwise added to a stirred solutionof substituted benzyl bromide (2.5 mmol) and 14 mL NaOHaqueous solution (1 M). The mixture is stirred at room temperaturefor 8-10 h. The soild was collected by filtration,washed with n-hexane and dried in vacuo.

Any one of these steps may be slow and thus may serve as the rate determining step. In general, however, in the presence of the catalyst, the overall rate of the reaction is faster than it would be if the reactants were in the gas or liquid phase.

Reference£º
Article; Jia, Ai-Quan; Ma, Sen; Wang, Jun-Ling; Zhang, Qian-Feng; Journal of Chemical Crystallography; (2020);,
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A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.26364-65-8, name is 2-Cyanoimino-1,3-thiazolidine. An updated downstream synthesis route of 26364-65-8 as follows., 26364-65-8

Procedure B. To a solution of RhA-8 (300 mg, 1.09 mmol) in ethanol(10 mL) was added slowly a solution of 3-amino-2-thioxothiazolidin-4-one (2, 158.2 mg, 1.09 mmol) in ethanol and was added to acetic acid(2 drops) as a catalyst. The reaction mixture was refluxed for 8 h, andwas monitored by TLC. After the completion of the reaction, the mixturewas cooled to room temperature. The red product formed wasrecrystallized from ethanol, filtered, and dried in vacuo. After recrystallization,4 (382 mg, 87%) was obtained as red solid(Mp:>300 C). 1H NMR (400 MHz, DMSO-d6): delta 12.41 (bs, NH, 1H),12.08 (bs, NH, 1H), 8.82 (s, N=CH, 1H), 8.22 (d, J=7.7 Hz, =CH,1H), 8.14-8.13 (m, =CH, 2H), 8.00-7.97 (m, =CH, 2H), 7.54-7.52 (m,=CH, 2H), 7.31-7.22 (m, =CH, 3H), 5.96 (s, =CH, 1H); 13C NMR(100 MHz, DMSO-d6): delta 206.9, 171.1, 165.7, 157.0, 147.8, 144.8,138.2, 137.3, 136.4, 135.6, 135.1, 130.7, 126.7, 124.2, 123.4, 122.3,121.6, 113.3, 112.6, 111.2, 110.3 (Fig. S9); IR (KBr, cm-1): 3242 cm-1 (=CeH), 1729 cm-1 (C]O), 1612 cm-1 (O]C-N-C]S), 1414,1315 cm-1 (C]S); ESI-MS (m/z) [M] calcd for C21H14N4OS2 402.49,found: 402.12.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 3-Aminorhodanine

Reference£º
Article; Bayindir; Caglayan, Cuneyt; Karaman, Muhammet; Guelcin, ?lhami; Bioorganic Chemistry; vol. 90; (2019);,
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A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.5908-62-3, name is 1,1-Dioxo-isothiazolidine. An updated downstream synthesis route of 5908-62-3 as follows., 5908-62-3

11.8 g (0.05 mL) of Compound X, 150 mL of DMF, 8.28 g (0.05 mL) of K2CO3 and 6.35 g of thiazolidine were added to a 150 mL three-necked flask, and reacted at 80 C for 4 h.Compound X disappeared by TLC. Filter by suction, take the filtrate, add 300mL after coolingWater, a large amount of solids are precipitated, stirred for a while, and then filtered.The filter cake is the product compound I. After drying, 14.15 g of a white solid was obtained, yield 86%., 26364-65-8

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 26364-65-8, you can also browse my other articles.

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Patent; Qingdao University of Science and Technology; Xu Liangzhong; Zhang Mingming; Sun Jianxin; Wang Minghui; (6 pag.)CN108440519; (2018); A;,
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One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level.1438-16-0, name is 3-Aminorhodanine, introduce a new downstream synthesis route. , 1438-16-0

5908-62-3, (1S,2S)-N1,N2-Dimethylcyclohexane-1,2-diamine (46.1 mg, 0.30 mmol) and copper iodide (56.3 mg, 0.30 mmol) were added to a mixture of 2,3-dichloro-5-nitropyridine (571 mg, 2.96 mmol), isothiazolidine 1,1-dioxide (430 mg, 3.55 mmol) and potassium carbonate (817.5 mg, 5.92 mmol) in dioxane (6 mL) under N2. The reaction mixture was stirred at 100 C. for 16 h. The mixture was filtered, and the filtrate was extracted with ethyl acetate. The organic extracts were dried over Na2SO4, filtered, and the filtrate concentrated under reduced pressure. The resultant crude product was purified by flash chromatography (petroleum ether/ethyl acetate=100:0 to petroleum ether/ethyl acetate=50:50) to afford compound 58a as a white solid (600 mg, 73%).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 5908-62-3, We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; Janssen Biotech, Inc.; Lu, Tianbao; Allison, Brett Douglas; Barbay, Joseph Kent; Connolly, Peter J.; Cummings, Maxwell David; Diels, Gaston; Edwards, James Patrick; Kreutter, Kevin D.; Philippar, Ulrike; Shen, Fang; Thuring, Johannes Wilhelmus John Fitzgerald; Wu, Tongfei; (412 pag.)US2018/170909; (2018); A1;,
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One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level.19771-63-2, name is (R)-2-Oxothiazolidine-4-carboxylic acid, introduce a new downstream synthesis route. , 19771-63-2

General procedure: A mixture of aminorhodanine (1 mmol), isatin (1 mmol) and 5 muL of acetic acid in 2mL of distilled ethanol was placed in a cylindrical quartz reactor (Phi = 4 cm). The reactor was introducedinto a monomode microwave (Anton Paar) apparatus, for 5 min at100 C and 50 Watts. The crude reaction mixture was allowed tocool down at room temperature and ethanol (10 mL) or mixture of H2O/EtOH (10 mL) was directly added in the cylindrical quartzreactor. The resulting precipitated product was filtered off and waspurified by recrystallization from ethanol if necessary.

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 1438-16-0, We look forward to the emergence of more reaction modes in the future.

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Article; Khaldoun, Khadidja; Safer, Abdelmounaim; Boukabcha, Nourdine; Dege, Necmi; Ruchaud, Sandrine; Souab, Mohamed; Bach, Stephane; Chouaih, Abdelkader; Saidi-Besbes, Salima; Journal of Molecular Structure; vol. 1192; (2019); p. 82 – 90;,
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One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level.7025-19-6, name is 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid, introduce a new downstream synthesis route. , 7025-19-6

EXAMPLE 18 (4R)-N-(2-Nitrooxypropyl)-2-oxothiazolidine-4-carboxamide (Compound No. 1-31) A procedure similar to that described in Example 1 was repeated, but using 2.0 g of (4R)-2-oxothiazolidine-4-carboxylic acid and 3.0 g of N-(2-nitrooxypropyl)amine nitrate, to obtain 24 mg of the title compound as pale yellow crystals, melting at 70-72 C. (after recrystallization from ethanol).

Thank you very much for taking the time to read this article. If you are also interested in other aspects of 19771-63-2, you can also browse my other articles.

Reference£º
Patent; Sankyo Company, Limited; US5298516; (1994); A;,
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