name: (R)-2-Oxothiazolidine-4-carboxylic acid, Name is (R)-2-Oxothiazolidine-4-carboxylic acid, belongs to thiazolidine compound, is a common compound. name: (R)-2-Oxothiazolidine-4-carboxylic acidIn an article, authors is Dholkawala, Fahd, once mentioned the new application about name: (R)-2-Oxothiazolidine-4-carboxylic acid.
Synthesis and characterization of brain penetrant prodrug of neuroprotective D-264: Potential therapeutic application in the treatment of Parkinson’s disease
Parkinson’s disease (PD) is one of the major debilitating neurodegenerative disorders affecting millions of people worldwide. Progressive loss of dopamine neurons resulting in development of motor dysfunction and other related non-motor symptoms is the hallmark of PD. Previously, we have reported on the neuroprotective property of a potent D3 preferring agonist D-264. In our goal to increase the bioavailability of D-264 in the brain, we have synthesized a modified cysteine based prodrug of D-264 and evaluated its potential in crossing the blood-brain barrier. Herein, we report the synthesis of a novel modified cysteine conjugated prodrug of potent neuroprotective D3 preferring agonist D-264 and systematic evaluation of the hydrolysis pattern of the prodrug to yield D-264 at different time intervals in rat plasma and brain homogenates using HPLC analysis. Furthermore, we have also performed in vivo experiments with the prodrug to evaluate its enhanced brain penetration ability.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 19771-63-2 is helpful to your research. name: (R)-2-Oxothiazolidine-4-carboxylic acid
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Quinuclidine – Wikipedia,
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