Recommanded Product: 94-41-7. Recently I am researching about NICKEL-CATALYZED HYDROCYANATION; PHOSPHINE-PHOSPHITE LIGANDS; ASYMMETRIC HYDROCYANATION; OLEFINS; ELECTROCHEMISTRY; OXIDATION; CYANATION; CHEMISTRY; HYBRID; BONDS, Saw an article supported by the NIGMSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R01GM130928]; Eli LillyEli Lilly; Cornell University; NSFNational Science Foundation (NSF) [CHE-1531632]; National Energy Research Scientific Computing Center (NERSC), a US Department of Energy Office of Science User Facility [DE-AC02-05CH11231]. Published in NATURE RESEARCH in BERLIN ,Authors: Song, L; Fu, NK; Ernst, BG; Lee, WH; Frederick, MO; DiStasio, RA; Lin, S. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone
Chiral nitriles and their derivatives are prevalent in pharmaceuticals and bioactive compounds. Enantioselective alkene hydrocyanation represents a convenient and efficient approach for synthesizing these molecules. However, a generally applicable method featuring a broad substrate scope and high functional group tolerance remains elusive. Here, we address this long-standing synthetic problem using dual electrocatalysis. Using this strategy, we leverage electrochemistry to seamlessly combine two canonical radical reactions-cobalt-mediated hydrogen-atom transfer and copper-promoted radical cyanation-to accomplish highly enantioselective hydrocyanation without the need for stoichiometric oxidants. We also harness electrochemistry’s unique feature of precise potential control to optimize the chemoselectivity of challenging substrates. Computational analysis uncovers the origin of enantio-induction, for which the chiral catalyst imparts a combination of attractive and repulsive non-covalent interactions to direct the enantio-determining C-CN bond formation. This work demonstrates the power of electrochemistry in accessing new chemical space and providing solutions to pertinent challenges in synthetic chemistry.
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