Computed Properties of C15H12O. In 2020.0 BIOORG MED CHEM LETT published article about ANTIDEPRESSANT; CYTOTOXICITY; FLAVONOIDS; INHIBITORS; ALKALOIDS; QUINOLONE in [Huang, Zhe-Hao; Li, Zhao-Hui] Jilin Univ, Dept Neurosurg, China Japan Union Hosp, Changchun 130033, Peoples R China; [Yin, Li-Quan] Jilin Univ, Rehabil Med Dept, China Japan Union Hosp, Changchun 130033, Peoples R China; [Guan, Li-Ping] Zhejiang Ocean Univ, Food & Pharm Coll, Zhoushan 316022, Peoples R China; [Tan, Cheng] Jilin Univ, Dept Neurol, China Japan Union Hosp, Changchun 130033, Peoples R China in 2020.0, Cited 31.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.
A group of 2-methyl-4-phenylquinoline-chalcone analogs (2a-2x) was synthesized and investigated for anti-depressant, anti-inflammatory, and analgesic effects as cyclooxygenase-2 inhibitors. Pharmacological experiments identified 24 analogs that exhibited anti-depressant, anti-inflammatory, and analgesic activities. In particular, compounds 2c, 2k, and 2w markedly shortened immobility times and exhibited the most anti-depressant activity. In addition, the mechanisms of action of the analogs 2c, 2k, and 2w were likely related to increased serotonin levels in the central nervous system. Compounds 2c, 2k, and 2w displayed reasonable cyclooxygenase-2 inhibitory effects (IC50 values from 0.21 to 0.29 mu mol/L) similar to celecoxib (IC50: 0.19 mu mol/L) in vitro. A molecular docking study of compound 2k also was conducted.
Computed Properties of C15H12O. Welcome to talk about 94-41-7, If you have any questions, you can contact Huang, ZH; Yin, LQ; Guan, LP; Li, ZH; Tan, C or send Email.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com