Heterocyclic Building Blocks-Thiazolidine

Authors Hagui, W; Essid, R; Amri, S; Feris, N; Khabbouchi, M; Tabbene, O; Limam, F; Srasra, E; Besbes, N in SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK published article about ANTI-HIV ACTIVITY; CARBONYL-COMPOUNDS; EFFICIENT SYNTHESIS; CHEMOSELECTIVE ACETALIZATION; MONTMORILLONITE CLAY; ANTIFUNGAL ACTIVITY; IONIC LIQUID; KETONES; ALDEHYDES; ACETALS in [Hagui, Wided; Amri, Sondes; Khabbouchi, Mohamed; Srasra, Ezzeddine; Besbes, Neji] Natl Ctr Res Mat Sci, Lab Composite Mat & Clay Minerals, Grp Green & Appl Organ Chem, Technopole Borj Cedria, Soliman, Tunisia; [Hagui, Wided; Amri, Sondes; Khabbouchi, Mohamed] Tunis El Manar Univ, Fac Sci Tunis, El Manar Tunis, Tunisia; [Essid, Rym; Feris, Nadia; Tabbene, Olfa; Limam, Ferid] Biotechnol Ctr Borj Cedria, Lab Bioact Subst, Technopole Borj Cedria, Soliman, Tunisia in 2019.0, Cited 78.0. Category: thiazolidines. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

A new heterogeneous acid catalyst based on a natural resource, Tunisian clay (Clay-H0.5), has been prepared and characterized by FT-IR, FE-SEM, and powder X-ray diffraction (XRD), as well as chemical composition, cation exchange capacity, specific surface area, and pore volume. Acid treatment for 0.5 h enlarged the surface area from 78.24 to 186.10 m(2)/g and pore volume (PV) from 0.186 to 0.281 cm(3)/g. The catalytic activity of this material was investigated in ketalization reaction under mild solvent-free conditions. This achieved up to 92% isolated yield for only 10 wt.% of the catalyst. This environmentally friendly method has advantages such as simple work-up procedure, avoidance of organic solvents, and good performance in ketalization reactions. Importantly, the Clay-H0.5 catalyst showed good recyclability where insignificant activity loss was exhibited even after six runs. Synthesized cyclic ketals were tested for their possible antileishmanial and antibacterial activities as well as antifungal activity. Biological screening showed that compound 11 had important antileishmanial activity against both L. major and L. infantum, while compound 14 also had significant antibacterial activity against four gram-positive and two gram-negative bacteria, and antifungal activity against Candida albicans, with minimal inhibitory concentration values ranging from 15.62 mu g/mL to 125 mu g/mL.

Category: thiazolidines. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recommanded Product: Chalcone. Authors Zhou, X; Ye, YQ; Liu, SS; Shao, WB; Liu, LW; Yang, S; Wu, ZB in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Zhou, Xiang; Ye, Yiqiang; Shao, Wubin; Liu, Liwei; Yang, Song; Wu, Zhibing] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Ctr R&D Fine Chem, Guiyang 550025, Peoples R China; [Liu, Shasha] Guizhou Univ, Coll Med, Guiyang 550025, Peoples R China in 2021, Cited 37. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Plant viral diseases, known as plant cancer, with high contagiosity can substantially reduce crop quality and yield. To identify potential anti-tobacco mosaic virus (TMV) agents with different mechanisms, a series of novel alpha-aminophosphonate derivatives containing a chalcone moiety were designed and synthesized. Bioassay results revealed that some target compounds exhibited improved curative activity against TMV in vivo, and the EC50 value of compound B-3 was 356.7 mg L-1. The activities of the defensive enzymes POD and CAT from tobacco leaves treated with B-3 and B-17 showed that these target compounds could improve the photosynthetic ability of the leaves and activate plant host resistance against TMV infection. The binding constant between B-3 and TMV Coat Protein (CP) (2.51 x 10(8) M-1), calculated by the fluorescence titration experiment and docking results, revealed that B-3 has a strong interaction with TMV CP. Further docking analysis revealed that B-3 was embedded between two layers of the TMV CP, which was consistent with the 2:1 binding mode of TMV CP and B-3 determined by the binding affinity experiment. The TEM morphological study of TMV treated with B-3 and B-17 indicated that this series of target compounds may trigger the disassembly of TMV by interacting directly with TMV CP. This study provides new insight for the discovery of antiviral compounds with two different mechanisms of action.

Recommanded Product: Chalcone. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recently I am researching about C BOND FORMATION; TRACELESS DIRECTING GROUPS; H ARYLATION; BENZOIC-ACIDS; ARYL; CYCLIZATION; ALKYNES; BETA; HYDROARYLATION; CONDENSATION, Saw an article supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy (EXC-2033)German Research Foundation (DFG) [390677874, SFB-TRR 88, GO 853/12-1]; BMBFFederal Ministry of Education & Research (BMBF); state of NRW (Center of Solvation Science ZEMOS); CSC. Application In Synthesis of Chalcone. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhang, GD; Hu, ZY; Bertoli, G; Goossen, LJ. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

A catalytic annulation is presented that provides straightforward, modular synthetic access to 3-substituted indanones from benzoic acids and alpha,beta-unsaturated ketones. It is catalyzed by a bimetallic Ir/In system and proceeds via hydroarylation followed by Claisen condensation and optional retro-Claisen deacylation. The annulation may be combined into a one-pot procedure with the synthesis of the unsaturated ketone substrates from aldehydes and acetone. Two complementary reaction protocols are provided that are applicable to diversely functionalized electron-rich and electron-poor substrates.

Welcome to talk about 94-41-7, If you have any questions, you can contact Zhang, GD; Hu, ZY; Bertoli, G; Goossen, LJ or send Email.. Application In Synthesis of Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recently I am researching about C-C ACTIVATION; RING-SLIPPAGE; H BOND; CLEAVAGE; BIOMASS; FUELS; ALKENYLATION; CHEMISTRY, Saw an article supported by the National Science FoundationNational Science Foundation (NSF) [CHE1664652]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Pannilawithana, N; Yi, CS. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone. Formula: C15H12O

The chelate assistance strategy was devised to promote a highly regioselective catalytic C-C bond activation reaction of saturated and unsaturated carbonyl compounds. The cationic Ru-H complex 1 was found to be an effective catalyst for mediating the coupling reaction of 1,2-disubstituted indoles with alpha,beta-unsaturated aldehydes and ketones, in which the regioselective C-alpha-C-beta activation of the carbonyl substrates has been achieved in forming the 3-alkylindole products. The analogous coupling reaction of indoles with saturated aldehydes and ketones directly led to the C-alpha- C-beta cleavage of the carbonyl substrates in forming the 3-allcylindole products. The coupling reaction of 1,2-dimethylinole with (E)-3-nonen-2-one and 2-propanol-d(8) showed 20-22% of deuterium incorporation to both alpha- and beta-CH2 of the 3-alkylindole product. The coupling reaction of 1,2-dimethylinole with (E)-3-nonen-2-one exhibited the most significant carbon kinetic isotope effect on the alpha-carbon of the product (C-alpha = 1.046). The Hammett plot constructed from the reaction of 1,2-dimethylinole with a series of para-substituted enones p-X-C6H4CH=CHCOCH3 (X = OMe, Me, H, Cl, CF3) showed a modest promotional effect by an electron-donating group (rho = -0.2 +/- 0.1). Several catalytically relevant Ru-H species were detected by NMR from a stoichiometric reaction mixture of the Ru-H complex 1 with 1,2-dimethylindole and (E)-3-nonen-2-one in CD2Cl2. These results support a mechanism of the catalytic coupling reaction via conjugate addition of indoles to enones followed by the C-C bond activation and hydrogenolysis steps.

About Chalcone, If you have any questions, you can contact Pannilawithana, N; Yi, CS or concate me.. Formula: C15H12O

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Wang, ZJ; Chen, WT; He, C; Zhang, GL; Yu, YP in [Wang, Zijuan; Chen, Wenteng; He, Chang; Zhang, Guolin; Yu, Yongping] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, 866 Yuhangtang Rd,Zijin Campus, Hangzhou 310058, Peoples R China published Palladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines in 2021.0, Cited 29.0. Computed Properties of C8H18O3. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7.

A one-pot method for joining three separate components leading to an assortment of 4-arylquinazolines (27 examples) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed- cascade reaction involving C(sp)-C(sp(2)) coupling followed by intramolecular C-N bond formation. The reaction was readily scaled up to gram quantity and successfully applied to the synthesis of a translocator- protein (TSPO) ligand.

Welcome to talk about 78-39-7, If you have any questions, you can contact Wang, ZJ; Chen, WT; He, C; Zhang, GL; Yu, YP or send Email.. Computed Properties of C8H18O3

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Schonbauer, D; Sambiagio, C; Noel, T; Schnurch, M in BEILSTEIN-INSTITUT published article about SP(3) C-H; PYRIDINIUM SALTS; PHOTOREDOX CATALYSIS; ORGANIC-SYNTHESIS; BOND; FUNCTIONALIZATION; ACTIVATION; EFFICIENT; REAGENTS in [Schoenbauer, David; Schnuerch, Michael] TU Wien, Inst Appl Synthet Chem, Getreidemarkt 9-163, A-1060 Vienna, Austria; [Sambiagio, Carlo; Noel, Timothy] Eindhoven Univ Technol, Dept Chem Engn & Chem, Micro Flow Chem & Synthet Methodol, Den Dolech 2, NL-5612 AZ Eindhoven, Netherlands in 2020.0, Cited 52.0. Quality Control of Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

A ruthenium-catalyzed photoredox coupling of substituted N-aryltetrahydroisoquinolines (THIQs) and different bench-stable pyridinium salts was successfully developed to give fast access to 1-benzyl-THIQs. Furthermore, secondary alkyl and allyl groups were also successfully introduced via the same method. Additionally, the typically applied N-phenyl group in the THIQ substrate could be replaced by the cleavable p-methoxyphenyl (PMP) group and successful N-deprotection was demonstrated.

Quality Control of Chalcone. Welcome to talk about 94-41-7, If you have any questions, you can contact Schonbauer, D; Sambiagio, C; Noel, T; Schnurch, M or send Email.

Reference:
Thiazolidine – Wikipedia,
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Authors Abdelrahman, M; Ariyanti, NA; Sawada, Y; Tsuji, F; Hirata, S; Hang, TTM; Okamoto, M; Yamada, Y; Tsugawa, H; Hirai, MY; Shigyo, M in MDPI published article about ALLIUM; ANTIOXIDANT; L. in [Abdelrahman, Mostafa] Aswan Univ, Fac Sci, Bot Dept, Aswan 81528, Egypt; [Ariyanti, Nur Aeni] Univ Negeri Yogyakarta, Fac Math & Nat Sci, Dept Biol Educ, Yogyakarta 55281, Indonesia; [Sawada, Yuji; Okamoto, Mami; Yamada, Yutaka; Tsugawa, Hiroshi; Hirai, Masami Yokota] RIKEN Ctr Sustainable Resource Sci, Tsurumi Ku, 1-7-22 Suehiro Cho, Yokohama, Kanagawa 2300045, Japan; [Tsuji, Fumitada] Ajinomoto Co Inc, Inst Food Sci & Technol, Kawasaki Ku, 1-1 Suzukicho, Kawasaki, Kanagawa 2108681, Japan; [Hirata, Sho] Kyushu Univ, Fac Agr, Lab Agroecol, Kasuya, Fukuoka 8112307, Japan; [Hang, Tran Thi Minh] Vietnam Natl Univ Agr, Dept Agron, Hanoi 100000, Vietnam; [Shigyo, Masayoshi] Yamaguchi Univ, Coll Agr, Grad Sch Sci & Technol Innovat, Lab Vegetable Crop Sci, Yamaguchi 7538515, Japan in 2020.0, Cited 34.0. HPLC of Formula: C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Shallot landraces and varieties are considered an important genetic resource for Allium breeding due to their high contents of several functional metabolites. Aiming to provide new genetic materials for the development of a novel bulb onion cultivar derived from intraspecific hybrids with useful agronomic traits from shallots, the metabolic profiles in the bulbs of 8 Indonesian shallot landraces and 7 short-day and 3 long-day bulb onion cultivars were established using LC-Q-TOF-MS/MS. Principal component analysis, partial least squares discriminant analysis, and dendrogram clustering analysis showed two major groups; group I contained all shallot landraces and group II contained all bulb onion cultivars, indicating that shallots exhibited a distinct metabolic profile in comparison with bulb onions. Variable importance in the projection and Spearman’s rank correlation indicated that free and conjugated amino acids, flavonoids (especially metabolites having flavonol aglycone), and anthocyanins, as well as organic acids, were among the top metabolite variables that were highly associated with shallot landraces. The absolute quantification of 21 amino acids using conventional HPLC analysis showed high contents in shallots rather than in bulb onions. The present study indicated that shallots reprogrammed their metabolism toward a high accumulation of amino acids and flavonoids as an adaptive mechanism in extremely hot tropical environments.

HPLC of Formula: C15H12O. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Zhang, ZY; Miao, YR; Xu, M; Cheng, WM; Yang, CY; She, XJ; Geng, QQ; Zhang, QL in ELSEVIER IRELAND LTD published article about CHINESE HERBAL MEDICINE; URSODEOXYCHOLIC ACID; ALLERGIC RHINITIS; LIVER; NAPHTHYLISOTHIOCYANATE; ACUPUNCTURE; EFFICACY in [Zhang, Zhiyong; Miao, Yiru; Xu, Min; Cheng, Wenming; Yang, Chuanyan; She, Xiangjian; Geng, Qianqian; Zhang, Qunlin] Anhui Med Univ, Sch Pharm, Hefei 230032, Anhui, Peoples R China in 2020.0, Cited 54.0. HPLC of Formula: C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

Ethnopharmacological relevance: TianJiu (TJ) therapy, one type of cold moxibustion, applies to specific acupuncture points with herbal patches of hot nature, providing a constant irritant to the skin until the presence of hyperemia and blistering. Traditional and clinical reports suggest that TJ is an effective therapy for the treatment of jaundice with fresh Ranunculus sceleratus L. (RS), in which protoanemonin is one of the main irritant constituents. However, the therapeutic effect of TJ treatment with fresh RS against intrahepatic cholestasis has not been studied in animal experiments. Aim of the study: Present study was undertaken to investigate the effect of TJ treatment with fresh RS against intrahepatic cholestasis in rats and provide an experimental basis for the underlying mechanism of TJ therapy. Materials and methods: Male intrahepatic cholestatic Sprague-Dawley rats induced by 2% alpha-naphthylisothiocyanate (ANIT, 80 mg/kg B.W.) were treated by TJ therapy with fresh RS. The levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), direct bilirubin (DBIL), total bilirubin (TBIL), total bile acid (TBA), hepatic malondialdehyde (MDA) and nitric monoxide (NO), as well as hepatic body ratio, bile flow and hepatic histopathological assay were measured and evaluated to investigate the therapeutic effect of TJ treatment with fresh RS. Phytochemical analysis of fresh and dried RS was performed by gas chromatography-mass spectrometer (GC-MS). Results: After TJ treatment with fresh RS, the abnormally elevated levels of serum AST, ALT, ALP, DBIL, TBIL and TBA, as well as hepatic MDA and NO at 108 h were reduced significantly (versus model group, P < 0.01). The hepatic body ratio, bile flow and hepatic pathological change of cholestatic rats at 108 h in TJ group were restored when compared with those of model group. Thirty-one compounds including lactones, flavonoids and phenolic acids were identified and determined by GC-MS analysis. The content of protoanemonin in fresh RS (9.49%) was about 25-fold higher than that in dried RS (0.38%). Conclusions: TJ treatment with fresh RS exhibited good therapeutic effect on ANIT-induced intrahepatic cholestasis in rats, which may be due to the attenuated oxidative stress in the liver tissue. It is rational for the ancients to choose fresh RS as TJ herbal patches because of its abundant protoanemonin with the character of irritant. The qualitative and quantitative results of GC-MS analysis provided the chemical basis of TJ therapy with fresh RS, which can be regarded as a simple and efficient method for the treatment of cholestasis hepatitis. Welcome to talk about 94-41-7, If you have any questions, you can contact Zhang, ZY; Miao, YR; Xu, M; Cheng, WM; Yang, CY; She, XJ; Geng, QQ; Zhang, QL or send Email.. HPLC of Formula: C15H12O

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In 2020.0 PLANT PHYSIOL BIOCH published article about FRAGARIA-X-ANANASSA; PHENYLALANINE AMMONIA-LYASE; TIME-QUANTITATIVE PCR; DIFFERENT CULTIVARS; GENE-EXPRESSION; DROUGHT STRESS; TOLERANCE; PROLINE; PLANT; MECHANISMS in [Crizel, R. L.; Perin, E. C.; Siebeneichler, T. J.; Borowski, J. M.; Messias, R. S.; Rombaldi, C., V; Galli, V] Univ Fed Pelotas, Pelotas, RS, Brazil in 2020.0, Cited 65.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Formula: C15H12O

Strawberry is one of the most popular fruits because of its sensorial and functional properties. However, strawberry crop is sensitive to salt stress conditions. Despite plants have plasticity, high salt concentrations induce molecular, biochemical, and physiological responses in plants. There is evidence that the abscisic acid (ABA) hormone acts as a signaling molecule under stress conditions; however, the molecular mechanisms involved in the synthesis and homeostasis of ABA and in the induction of phytochemical antioxidant compounds under stress conditions remain unclear. In this study, the effect of stress induced by NaCl (salt stress – SS), with or without the simultaneous application of ABA, on the ABA, phenylpropanoids and L-ascorbic acid (AsA) metabolisms were evaluated. The physiological aspects (Na, Cl and proline concentration, photosynthetic variables) were also studied. The results showed that salt stress increases the Na and Cl content in the leaves, affects photosynthetic variables and triggers the production of proline, pelargonidin-3-O-glucoside, total phenolic compounds and AsA content, alongside the upregulation of several genes from the phenylpropanoid and flavonoid pathways. These effects were accompanied by the induction of compounds and transcripts related to ABA biosynthesis, conjugation and catabolism. Otherwise, the exogenous application of ABA in salt stressed plants promotes a shift in gene expression and metabolism to mitigate the stress. Therefore, salt stress affects the metabolism of ABA, phenylpropanoids and AsA in strawberry increasing phytochemical composition which is strongly associated with an ABA-dependent mechanism.

Formula: C15H12O. Welcome to talk about 94-41-7, If you have any questions, you can contact Crizel, RL; Perin, EC; Siebeneichler, TJ; Borowski, JM; Messias, RS; Rombaldi, CV; Galli, V or send Email.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Computed Properties of C8H18O3. Maher, M; Kassab, AE; Zaher, AF; Mahmoud, Z in [Maher, Mai; Kassab, Asmaa E.; Zaher, Ashraf F.; Mahmoud, Zeinab] Cairo Univ, Dept Organ Pharmaceut Chem, Fac Pharm, Cairo 11562, Egypt published Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3-mediated apoptosis in 2019.0, Cited 36.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7.

A series of novel pyrazolo[3,4-d]pyrimidines was synthesised. Twelve synthesised compounds were evaluated for their anticancer activity against 60 human tumour cell lines by NCI (USA). Compound 7d proved prominent anticancer activity. It showed 1.6-fold more potent anti-proliferative activity against OVCAR-4 cell line with IC50 = 1.74 mu M. It also exhibited promising potent anticancer activity against ACHN cell line with IC50 value 5.53 mu M, representing 2.2-fold more potency than Erlotinib. Regarding NCI-H460 cell line, compound 7d (IC50 = 4.44 mu M) was 1.9-fold more potent than Erlotinib. It inhibited EGFR and ErbB2 kinases at sub-micromolar level (IC50 = 0.18 and 0.25 mu M, respectively). Dual inhibition of EGFR and ErbB2 caused induction of apoptosis which was confirmed by a significant increase in the level of active caspase-3 (11-fold). It showed accumulation of cells in pre-G1 phase and cell cycle arrest at G2/M phase.

Welcome to talk about 78-39-7, If you have any questions, you can contact Maher, M; Kassab, AE; Zaher, AF; Mahmoud, Z or send Email.. Computed Properties of C8H18O3

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com