Name: 1,1,1-Triethoxyethane. I found the field of Chemistry very interesting. Saw the article Site-Selective 1,1-Difunctionalization of Unactivated Alkenes Enabled by Cationic Palladium Catalysis published in 2019.0, Reprint Addresses Baik, MH; Hong, S (corresponding author), Korea Adv Inst Sci & Technol, Dept Chem, Daejeon 34141, South Korea.. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane.
A palladium(II)-catalyzed 1,1-difunctionalization of unactivated terminal and internal alkenes via addition of two nucleophiles was developed using a cationic palladium(II) complex. The palladacycle generated in situ as a result of a regioselective addition of a nucleophile to the alkene can readily undergo regioselective beta-hydride elimination and migratory insertion with a cationic palladium catalyst. The resulting eta(3)-pi-allyl palladium(II) complex is the key intermediate that reacts with a second nucleophile to furnish the desired 1,1-difunctionalization of the alkene. Under the optimized reaction conditions, a wide range of indoles and anilines add to alkene units of 3-butenoic or 4-pentenoic acid derivatives to afford the synthetically useful gamma,gamma- or delta,delta-difunctionalized products with excellent regiocontrol. Furthermore, by employing internal hydroxyl or acid groups and external carbon nucleophiles, this transformation enables unsymmetric 1,1-difunctionalization to forge challenging and important oxo quaternary carbon centers. Combining experiments and DFT calculations on the mechanism of the reaction is investigated in detail.
Name: 1,1,1-Triethoxyethane. Welcome to talk about 78-39-7, If you have any questions, you can contact Jeon, J; Ryu, H; Lee, C; Cho, D; Baik, MH; Hong, S or send Email.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com