Chemical Research Letters, May 2021. An article , which mentions Application In Synthesis of Thiazolidin-2-one, molecular formula is C3H5NOS. The compound – Thiazolidin-2-one played an important role in people’s production and life., Application In Synthesis of Thiazolidin-2-one
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric (containing alpha and beta subunits) transcription factor, is involved in hypoxia response pathway that regulates the expression of many tumor-related genes. The stabilized HIF-1 heterodimer couples to the general co-activators p300/CBP (CREB binding protein), forming an active transcription factor to initiate hypoxic responses. Inhibiting the transcription factor-coactivator HIF-1alpha-p300/CBP interaction represents an attractive approach for blocking hypoxia pathway in tumors. Recently, diverse HIF-1alpha-p300/CBP inhibitors have been designed and their anti-tumor activities have been evaluated. The developments of inhibitors of HIF-1alpha-p300/CBP are discussed in this review. An outline of structures and biological activities of these inhibitors can be traced, along with the approaches for inhibitors discovery. The challenges in identifying novel and selective potent inhibitors of HIF-1alpha-p300/CBP are also put forward.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application In Synthesis of Thiazolidin-2-one, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2682-49-7, in my other articles.
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Quinuclidine – Wikipedia,
Quinuclidine | C7H480N | ChemSpider