Tag: M.W:100-200

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: thiazolidine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 2682-49-7, name is Thiazolidin-2-one. In an article£¬Which mentioned a new discovery about 2682-49-7

Design, synthesis of biologically active heterocycles containing Indol- Thiazolyl- Thiazolidinone derivatives

Objective: The present study envisage a novel series of thiazole, indole and thiazolidine derivatives, namely, N-((5-Substituted-2-phenyl-1 H-indol-3-yl)methylene)-4,5,6,7-tetrahydro-5,7,-dimethylbenzo [d]thiazole-2-amine (4a-c), 2-(5-substituted-2-phenyl-1H-indol-3-yl)-3-(4,5,6,7-trimethylbenzo[d]thiazol-2-yl)-thiazolidin-4-one (5a-c) and 5-benzylidine-2-(5-substituted-2phenyl-1H-indol-3yl)-3-(4,5,6,7-tetrahydro-5,5,7-trimethylbenzo[d]thiazol-2-yl) thiazolidin-4-one (6a-c). Methods: All the newly synthesized compounds were characterized by infrared,1H,13C nuclear magnetic resonance and mass spectral data and elemental analysis and evaluated for in vitro antimicrobial activity. Results: Novel compounds N-((5-Substituted-2-phenyl-1H-indol-3-yl)methylene)-4,5,6,7-tetrahydro-5,7,-dimethylbenzo [d]thiazole-2-amine (4a-c), 2-(5-substituted-2-phenyl-1H-indol-3-yl)-3-(4,5,6,7-trimethylbenzo[d]thiazol-2-yl)-thiazolidin-4-one (5a-c) and 5-benzylidine-2-(5-substituted-2phenyl-1H-indol-3yl)-3-(4,5,6,7-tetrahydro-5,5,7-trimethyl benzo[d]thiazol-2-yl)thiazolidin-4-one (6a-c) have been made and characterized using spectral and analytical data. The results of antibacterial and antifungal activities showed that some of the synthesized compounds exhibited promising activities. Conclusion: All the newly synthesized compounds were carried out by the broth microdilution method (NCCLS. 2002) in a DMF concentration of 500, 250, 125, and 62.5 mug/ml. Gentamycin and fluconazole are used as reference standards for antibacterial and antifungal activity, respectively. The final results revealed that compounds 4b, 5b, and 6b exhibited potent antimicrobial activity when compared to the standard drugs.

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Reference of 2682-49-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2682-49-7, Name is Thiazolidin-2-one, molecular formula is C3H5NOS. In a Article£¬once mentioned of 2682-49-7

Synthesis and biological activity of some new 4-thiazolidinones

New heterocyclic compounds are of major importance because of growing problem of bacteria and fungi resistance and antimicrobial thiazolidinone have been gaining a lot of interest. A series of Thiazolidine-4-ones derivatives as antimicrobial agent were synthesized and screened for antibacterial activity against S. aureus, E. coli and P. vulgaris and antifungal activity against A. fumigatus, C. albicans and C. albicans ATCC. The structure of the newly synthesised compounds have been confirmed from elemental analysis, IR and 1HNMR data.

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Related Products of 76186-04-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.76186-04-4, Name is (S)-4-Isopropylthiazolidine-2-thione, molecular formula is C6H11NS2. In a Article£¬once mentioned of 76186-04-4

A novel chiral silver(I) complex from the reaction of thiazolidinethione with AgOAc

A novel chiral silver(I) complex was successfully synthesized from the reaction of chiral (S)-4-isopropylthiazolidine-2-thione ligand (1) with AgOAc in dichloromethane in the presence of Et3N and DMAP at room temperature. Its unique crystal structure was unambiguously disclosed by X-ray analysis. The six silver atoms and six (S)-4-isopropylthiazolidine-2-thione ligands present in the complex are connected through the S and N atoms to form a cluster containing a silver octahedron with six faces of the octahedron capped by ligands. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

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Synthetic Route of 2682-49-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2682-49-7, Name is Thiazolidin-2-one, molecular formula is C3H5NOS. In a Article£¬once mentioned of 2682-49-7

Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents

As a part of ongoing studies in developing new anticancer agents, novel 1,2-dihydropyridine 4, thienopyridine 5, isoquinolines 6-20, acrylamide 21, thiazolidine 22, thiazoles 23-29 and thiophenes 33-35 bearing a biologically active quinoline nucleus were synthesized. The structure of newly synthesized compounds was confirmed on the basis of elemental analyses and spectral data. All the newly synthesized compounds were evaluated for their cytotoxic activity against the breast cancer cell line MCF7. 2,3-Dihydrothiazole-5-carboxamides 27, 25, 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (34), 1,2-dihydroisoquinoline-7-carbonitrile (7), 5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide (35), 1,2-dihydroisoquinoline-7-carbonitrile (6), 2-cyano-3-(dimethylamino)-N-(quinolin-3-yl)acrylamide (21), 1,2-dihydroisoquinoline-7-carbonitriles (11) and (8) exhibited higher activity (IC50 values of 27-45 mumol L-1) compared to doxorubicin (IC50 47.9 mumol L-1). LQ quinolin-3-yl)-1,2-dihydroisoquinoline-7-carbonitrile (12), 2-thioxo-2,3-dihydrothiazole-5-carboxamide (28) and quinolin-3-yl)-1,2-dihydroisoquinoline-7-carbonitrile (15) show activity comparable to doxorubicin, while (quinolin-3-yl)-1,2-dihydroisoquinoline-7-carbonitrile (9), 2,3-dihydrothiazole-5-carboxamide (24), thieno [3,4-c] pyridine-4(5H)-one (5), cyclopenta[b]thiophene-3-carboxamide (33) and (quinolin-3-yl)-6-stryl-1,2-dihydroisoquinoline-7-carbonitrile (10) exhibited moderate activity, lower than doxorubicin.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 2682-49-7. In my other articles, you can also check out more blogs about 2682-49-7

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 2682-49-7, name is Thiazolidin-2-one, introducing its new discovery. Product Details of 2682-49-7

Microwave-assisted synthesis, characterization and antimicrobial potencies of n-substituted iminothiazodin-4-one derivatives

The biggest and most multifaceted class of organic compounds includes heterocyclic compounds. Currently, several heterocyclic compounds are iden-tified, and persistently gratefulness to tremendous synthetic work and synthetic usefulness, the number is increasing exponentially. In most fields of science, including medicinal, pharmaceutical, and agro-chemistry, heterocyclic compounds have a function, and biochemistry is also another area. In this research article, the green approach is administered for achieving the nitrogen, oxygen and sulphur centered five-membered heterocyclic derivatives. By taking the whole thing in to account of hetero-chemistry, the moderately effective analog for gram-positive and gram-negative bacterial strains was shown for the five-membered heterocyclic compound series of N-substituted iminothiazodine-4-one and N-(benzylideneamino)thiazol-4(5H). Throughout the synthesized series of the compound 6c revealed very much active potent against the gram-negative Escherichia coli bacterial strain and the compound 6b point out moderately active against the gram-positive Bacillus subtilis bacteria strains in accordance with the standard drug. The 5a and 6a compounds showed very strong activity against the fungal strain of Candida albicans and 6b as well as 6c were more active and highly potent than the standard drugs against Aspergillus niger species. In the view of this research drive states that all the synthesized compounds might be used for the development for further heterocyclic entities.

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Related Products of 2682-49-7, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 2682-49-7, Name is Thiazolidin-2-one,introducing its new discovery.

Highly Regioselective Organocatalytic SNAr Amination of 2,4-Dichloropyrimidine and Related Heteroaryl Chlorides

A highly efficient and regioselective method for the SNAr amination of 2,4-dichloropyrimidine with oxazolidin-2-one and related weakly nucleophilic amines, using sodium sulfinate and tetrabutylammonium bromide as catalysts, is disclosed. This strategy facilitates the synthesis of various aminopyrimidines in a regio- and chemoselective manner. This approach was successfully used for the amination of various activated N-heteroaromatic substrates.

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Safety of 1,1-Dioxo-isothiazolidine. Introducing a new discovery about 5908-62-3, Name is 1,1-Dioxo-isothiazolidine

HEPATITIS B ANTIVIRAL AGENTS

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R??(I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

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Synthetic Route of 2682-49-7, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 2682-49-7, Name is Thiazolidin-2-one,introducing its new discovery.

Theoretical study of the structural features and antioxidant potential of 4-thiazolidinones

4-Thiazolidinone compounds have been reported to display good antioxidant activity. In the present work, the five-membered ring has been studied extensively at the DFT-B3LYP/6-311(++)G(d,p) level of theory. The geometrical features of the ring have been explored in the gas and solvent phase. Various molecular descriptor characteristics of the antioxidant compound have been calculated and compared with the reference antioxidant, trolox. Three probable antioxidant mechanisms, hydrogen atom transfer (HAT), single electron transfer (SET), and sequential proton loss electron transfer (SPLET), have been explored, both in the gas and solvent phase. It has been found that the ring exerts its antioxidant activity predominantly following the HAT pathway, both in the gas and solvent phase. In order to determine the feasibility of the overall redox reaction, the standard redox potentials have been calculated for the ring and free radicals. Furthermore, the effect of substitution on the antioxidant parameters of the ring has been explored. Results indicate that substitution at the C2 position is advantageous over that at C5 in improving such parameters. Along with this, the effect of substitution at the C2 position on the proton affinity of the C5 position has also been investigated in detail.

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Quinuclidine | C7H458N | ChemSpider

Reference of 2682-49-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2682-49-7, Name is Thiazolidin-2-one, molecular formula is C3H5NOS. In a Article£¬once mentioned of 2682-49-7

One-pot synthesis of 4-thiazolidinone derivatives catalyzed by zinc acetate-schiff base complex immobilized on mesoporous molecular sieve MCM-41

A new simple and efficient one-pot synthesis of thiazolidinone derivatives via aldehydes, amines and mercaptoacetic acid in the presence of Zn(OAc)2-Schiff base complex immobilized on MCM-41 is described. A variety of aldehydes and amines were engaged in the study and afforded respective thiazolidinones in high yield (up to 98%). Moreover, consistent activity of recovered catalyst was found to be almost same up to five cycles in 80% yield.

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Electric Literature of 2682-49-7, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 2682-49-7, Name is Thiazolidin-2-one,introducing its new discovery.

Synthesis, molecular modelling, and preliminary anticonvulsant activity evaluation of novel naphthalen-2-yl acetate and 1, 6-dithia-4, 9-diazaspiro [4.4] nonane-3, 8-dione derivatives

The synthesis, pharmacological evaluation and molecular modelling study of novel naphthalen-2-yl acetate and 1, 6-dithia-4, 9-diazaspiro [4.4]nonane-3, 8-dione derivatives as potential anticonvulsant agents are described. The newly synthesized compounds were characterized by both analytical and spectral data. Alkylation of 1H-imidazole or substituted piperazine with 1-(2-naphthyl)-2-bromoethanone (2) gave naphthalen-2-yl 2-(1H-imidazol-1-yl) acetate (3) and naphthalen-2-yl 2-(substituted piperazin-1-yl) acetate (4?8). Moreover, condensation of naphthalen-2-yl 2-bromoacetate or 2-bromo-1-(naphthalen-2-yl) ethanone with hydrazine hydrate and acetylacetone resulted in the formation of the cyclic pyrazole products 9 and 13. Sonication of naphthalen-2-yl acetate (1) with 2-chloropyridine, 2-chloropyrimidine and 2-(chloromethyl) oxirane gave naphthalen-2-yl 2-(pyridin-2-yl) acetate (10), naphthalen-2-yl 2-(pyrimidin-2-yl) acetate (11) and naphthalen-2-yl-3-(oxiran-2-yl) propanoate (12) respectively. Cyclocondensation reaction of 2-iminothiazolidin-4-one (14) with thioglycolic acid, thiolactic acid and thiomalic acid gave 1, 6-dithia-4, 9-diazaspiro [4.4]nonane-3, 8-dione derivatives (15?17). The compounds were tested?in vivo?for the anticonvulsant activity by delaying strychnine-induced seizures. The diazaspirononane (17) and 1-(2-naphthyl)-2-bromoethanone (2) showed a high significant delay in the onset of convulsion and prolongation of survival time compared to phenobarbital. The molecular modelling study of anticonvulsant activity of synthesized compounds showed a CNS depressant activity via modulation of benzodiazepine allosteric site in GABA-A receptors.

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