Tag: M.W:100-200

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid, is researched, Molecular C10H11NO2, CAS is 114527-53-6, about Catalytic Hydrogenation of Substituted Quinolines on Co-Graphene Composites.SDS of cas: 114527-53-6.

A set of 20 composites was prepared by pyrolysis of Co2+ complexes with 1,10-phenanthroline, melamine and 1,2-diaminobenzene. These composites were tested as the catalysts for the hydrogenation of quinolines. As shown by powder X-ray diffraction and TEM, the composites contained Co particles of several dozen nm sizes. The composition (elements content), Raman spectra X-ray photoelectron spectra parameters of the composites were analyzed. It was found that there was no distinct factor that controlled the yield of 1,2,3,4-tetrahydroquinolines in the investigated process. The yields of the resp. products were in the range 90-100%. The three most active composites were selected for scale-up and hydrogenation of a series of substituted quinolines. Up to 97% yield of 1,2,3,4-tetrahydroquinoline was obtained on a 50 g scale. Five representative substituted quinolines were synthesized on a 10-20 g scale using the Co-containing composites as the catalysts.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Derivatives of pyrrylazobenzenearsonic acids》. Authors are Muic, N.; Fles, D..The article about the compound:Ethyl 3,5-Dimethyl-2-pyrrolecarboxylatecas:2199-44-2,SMILESS:O=C(C1=C(C)C=C(C)N1)OCC).SDS of cas: 2199-44-2. Through the article, more information about this compound (cas:2199-44-2) is conveyed.

cf. C.A. 45, 9526a. The synthesis is essentially the same as previously described. 2,4-Dimethyl-3,5-carbethoxypyrrole (I) was prepared by the method of Knorr. I was saponified in 10% KOEt, and converted to 2,4-dimethyl-3-carbethoxy-5-pyrrolecarboxylic acid (II) by the method of Küster, et al. (C.A. 16, 3895). Decarboxylation of II by dry distillation gave 2,4-dimethyl-3-carbethoxypyrrole (III). I was also treated with concentrated H2SO4 by the method of Fischer and Walach (C.A. 20, 1620) to give 2,4-dimethyl-5-carbethoxy-3-pyrrolecarboxylic acid, which was decarboxylated by heating at atm. pressure to 2,4-dimethyl-5-carbethoxypyrrole (IV). Attempts to couple diazotized 4, 3-H2N(O2N)C6H3AsO3H2 and III were not successful; a resinous product, which could not be purified, was obtained, and III was isolated from the reaction mixture Attempts to couple a salt of diazotized 3,4-H2N(HO)C6H3AsO3H2 (V) with IV were also unsuccessful. p-H2NC6H4AsO3H2 (4.34 g.) in 50 cc. H2O containing 1.63 cc. concentrated H2SO4 was diazotized with 20 cc. N NaNO2 at 0-5° and the product filtered into 3.34 g. III in 200 cc. absolute EtOH. 4-(3-Carbethoxy-2,4-dimethyl-5-pyrrylazo)benzenearsonic acid (VI) precipitated as an orange-yellow powder. VI was filtered, rinsed with water, dissolved in aqueous NaOH, and the solution clarified with active C; acidification with dilute HCl gave 4.3 g. VI, orange-yellow microcrystals, decompose 210°, slightly soluble in water, somewhat more soluble in EtOH, nearly insoluble in C6H6 and ether, and soluble in dioxane; crystallization from dioxane gave well-formed needles. VI was precipitated from alk. solution with dilute acids. VI was stable in air under light. V (4.66 g.) in 70 cc. H2O containing 5.8 cc. concentrated H2SO4 was diazotized as above and the product filtered into 3.34 g. III in 200 cc. absolute EtOH. 2-(3-Carbethoxy-2,4-dimethyl-5-pyrrylazo)-1-phenol-4-arsonic acid (VII) precipitated, and addnl. amounts of VII were obtained on diluting with H2O. VII was then dissolved in N NaOH, the solution clarified with active C, added to 0.1 N HCl with constant stirring, and the precipitate was filtered, washed with H2O, dried, and recrystallized twice from dioxane to yield 7.2 g. VII, yellow needles, decompose 160°. VII was stable in air under light. (p-H2NC6H4)2As(:O)OH (1.46 g.) in 30 cc. H2O containing 3.7 cc. concentrated HCl was diazotized as above with 10 cc. N NaNO2 and the solution added dropwise at 5° or lower to 1.67 g. III in 70 cc. EtOH containing 5 g. NaOAc, previously dissolved in a small volume of H2O, to yield di-Et 5, 5′-[arsinobis(p-phenyleneazo)]bis[2,4-dimethyl-3-pyrrolecarboxylate] (VIII). VIII was filtered, washed with cold H2O, dried in vacuo, and recrystallized from dioxane and then from ether to yield 1 g. VIII, dark orange microcrystals, m. 151° (decomposition). VIII was soluble in EtOH, dioxane, and CHCl3. p-H2NC6H4AsO3H2 (2.17 g.) in 25 cc. H2O containing 0.81 cc. concentrated H2SO4 was diazotized with 10 cc. N NaNO2 and the product filtered into 1.67 g. IV in 200 cc. absolute EtOH; when the solution was clear 15 g. NaOAc in a small amount of H2O was added with cooling, and, after 1 hr., 4 l. H2O was added to precipitate 4-(5-carbethoxy-2,4-dimethyl-3-pyrrylazo)benzenearsonic acid (IX), yellow-orange powder. IX was twice dissolved in alkali and reprecipitated by dilute HCl, washed with water, and dried in vacuo to yield 1.2 g. IX, darkens 100°, m. 185° (decomposition), IX was soluble in EtOH and dioxane, and stable in air under light.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of pyrrolecarboxaldehydes, published in 1956, which mentions a compound: 2199-44-2, Name is Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, Molecular C9H13NO2, Application of 2199-44-2.

HCO-NMe2 (I) (23.89 g.) and 58.25 g. POCl3 warmed after 10 min. to 60°, treated dropwise in 1.5 hrs. with 18 g. 2,4-dimethylpyrrole in an equal volume of I, the mixture stirred 1 hr. at 60°, poured into 333 g. ice and 245 g. fused NaOAc, the mixture boiled, cooled, extracted with Et2O, the extract evaporated free from Et2O and made alk. with powd. Na2CO3, filtered, and the residual product (II) dried. Further extraction of the filtrate with Et2O gave another 0.69 g. II. II boiled in petr. ether, the solution purified with C, filtered and cooled gave 0.6 g. (crude) 2,4-dimethyl-3,5-pyrroledicarboxaldehyde, m. 165-6° (from H2O), and 9.6 g. (crude) 2,4-dimethyl-5-pyrrolecarboxaldehyde, m. 89-90° (from H2O). Similarly, I and POCl3 at 60°, treated dropwise with stirring with 2,4-dimethyl-8-ethylpyrrole gave 2,4-dimethyl-3-ethyl-5-pyrrolecarboxaldehyde, m. 105-6°. In the same way, 1.79 g. I and 4.37 g. POCl3 treated with 1.35 g. 2,3,4-trimethylpyrrole gave 0.3 g. 2,3,4-trimethyl-5-pyrrolecarboxaldehyde, m. 147°; 2.6 g. I and 6.32 g. POCl3 with 3 g. Et 2,4-dimethyl-3-pyrrolecarboxylate in I yielded Et 2,4-dimethyl-5-formyl-3-pyrrolecarboxylate, m. 165°; 8.6 g. I and 21 g. POCl3 with 10 g. Et 2,4-dimethyl-5-pyrrolecarboxylate and 10 g. I produced 11.2 g. Et 2,4-dimethyl-3-formyl-5-pyrrolecarboxylate, m. 145°. Heating 20 g. 2,4-dimethyl-5-carbethoxy-3-pyrrolecarboxylate at 200° with 200 g. quinoline and 2 g. finely divided pure Cu to cessation of CO2 evolution, cooling, filtering, acidifying the filtrate with 50% HCl, filtering, washing the precipitate with H2O, and drying gave 11.2 g. Et 2,4-dimethyl-5-pyrrolecarboxylic acid, m. 122°.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Decarboxylation and formylation of certain pyrrole derivatives, published in 1954, which mentions a compound: 2199-44-2, mainly applied to , Name: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate.

H2NCH2CH2OH (I) is used as decarboxylation agent for substituted carboxypyrroles. Adding 28.5 g. AcCH2CO2Et to Et α-nitroso-α-benzoylacetate (from 38.5 g. BzCH2CO2Et), then adding gradually 28.5 g. Zn dust with gentle boiling, refluxing the mixture 2 hrs., and pouring it into H2O give 63% 2-methyl-4-phenyl-3,5-dicarbethoxypyrrole, colorless prisms, m. 124-5°. 2,4-Dimethyl-3-carboxy-5-carbethoxypyrrole (II), 85%, fine prisms, m. 272° (decomposition), and 2-methyl-4-phenyl-3-carboxy-5-carbethoxypyrrole (III), 78%, platelets, m. 220° (decomposition) are prepared by partial saponification of the corresponding diesters. Refluxing 21.1 g. II and 12.2 g. I 1 hr. and pouring the mixture into H2O give 90% 2,4-dimethyl-5-carbethoxypyrrole (IV), prisms, m. 124.5-5°; similarly, III gives 84% 2-methyl-4-phenyl-5-carbethoxypyrrole, needles, m. 134.5-5°. Gradually adding 15.4 g. POCl3 to 13.4 g. IV and 7.3 g. HCONMe2, refluxing the mixture 2 hrs., pouring it into H2O, and neutralizing it with NaOAc give 95% 2,4-dimethyl-3-formyl-5-carbethoxypyrrole, needles, m. 145-5.5° (oxime, m. 199-200°; semicarbazone, decompose at about 275°). 2-Methyl-4-phenyl-3-formyl-5-carbethoxypyrrole, prepared similarly in 97% yield, prisms, m. 144.5-5° (oxime, 96%, plates, m. 210-11°; semicarbazone, needles, decompose at about 280° with sublimation).

In some applications, this compound(2199-44-2)Name: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Groves, Brandon R.; Smithen, Deborah A.; Cameron, T. Stanley; Thompson, Alison published the article 《Thionation reactions of 2-pyrrole carboxylates》. Keywords: pyrrolyl thionoester preparation; pyrrole carboxylate thionation Lawesson reagent.They researched the compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ).Computed Properties of C9H13NO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2199-44-2) here.

The reaction of 2-pyrrole carboxylates I [R = H, CH3; R1 = CH3, (CH2)4CH3, C6H5, etc.; R2 = CH3, CH2CH3, (CH2)2CH3; R3 = CH2CH3, C6H5CH2; X = O] with Lawesson’s reagent at elevated temperatures results in the corresponding thionoesters, I [X = S] concurrent with the production of a new class of pyrrole annulated with the (1,3,2)-thiazaphospholidine unit II. Addition of BF3·OEt2 to the thionation procedure was found to produce the corresponding F-BODIPY, III constituting a four-step reaction in one-pot. The scope and limitations of these reactions involving the promiscuous Lawesson’s reagent were described.

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Product Details of 2199-44-2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, is researched, Molecular C9H13NO2, CAS is 2199-44-2, about Synthesis of cyanopyrroles. Author is Cheng, Ling Jiang; Lightner, David A..

Regioselective synthesis of α-cyanopyrroles (vs. α-alkoxycarbonylpyrroles) using oximinocyanoacetate esters in a Knorr-type reductive condensation with β-diketones can be directed by the presence of water. Thus, HON:C(CN)CO2Me was reacted with CH2Ac2 in hot AcOH in the presence of Zn dust to give exclusively 3,5-dimethylpyrrole-2-carbonitrile when the AcOH was wet. Whereas, in glacial AcOH, only Me 3,5-dimethylpyrrole-2-carboxylate was isolated in ∼40% yield.

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Quality Control of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, is researched, Molecular C9H13NO2, CAS is 2199-44-2, about Pyrrole chemistry. An improved synthesis of ethyl pyrrole-2-carboxylate esters from diethyl aminomalonate. Author is Paine, John B. III; Dolphin, David.

Pyrrole-2-carboxylates I (R = Me, Et; R1 = H, Me, Et, Pr, CH2CO2Me, CH2CH2CO2Me; R2 = Me, Et, Pr, CH2CH2CO2Et), versatile precursors for the total synthesis of both synthetic model and naturally occurring tetrapyrroles and porphyrins, were prepared in greatly improved yields by the addition of RCOCHR1COR2 and H2NCH(CO2)Et)2 to AcOH. The method is suitable for both small- and large-scale synthesis and has proved far more reliable than the in situ Zn reduction of HON:C(CO2Et)2. Yields range from 60-70% for the dominant product isomer from unsym. diketones to 75-90% for the single product derived from sym. diketones. RCOCHR1COR2 were prepared by treating RCOCHR1 with (R2CO)2O in the presence of BF3.

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Electric Literature of C9H13NO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, is researched, Molecular C9H13NO2, CAS is 2199-44-2, about Protonated Nitrogen Structure in 15N-Labeled Model Coal Investigated by Solid-State 1H-15N Double-CP NMR Experiments under Ultrafast Magic-Angle Spinning. Author is Okushita, Keiko; Hata, Yuki; Sugimoto, Yoshikazu; Takahashi, Takafumi; Kanehashi, Koji.

The nitrogen structure in coals has been focused on as a key factor for reducing NOx. Solid-state NMR (NMR) with high spectral resolution can be an effective tool for analyzing the nitrogen structure of coals once higher sensitivity is achieved in the future. To investigate the nitrogen structure in coals and coal-related mols., we acquired quant. 15N magic-angle spinning (MAS) NMR spectra of 15N-labeled synthesized coals produced from three different types of 15N-reagents. There were some variations in the relative peak intensity ratios of 15N MAS NMR spectra of the three model coals; in particular, the 15N-uracil-origin model coal showed a remarkable difference. Then, we elucidated the chem. environment around the 15N nuclei in the synthesized 15N-labeled coals using 1H-15N double cross-polarization techniques under the ultrafast MAS condition. From the 2D NMR results, it was clarified that there exist not only pyrrolic nitrogen groups but also amide-type nitrogen functional groups in the 1H-15N bonded region of the model coal with a sub-bituminous-level degree of carbonization.

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Dudina, N. A.; Antina, E. V.; Guseva, G. B.; V’yugin, A. I.; Semeikin, A. S. published the article 《New fluorescent chemosensor for Zn2+ ions on the basis of 3,3′-bis(dipyrrolylmethene)》. Keywords: fluorescent chemosensor zinc ion dipyrrolylmethene.They researched the compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ).Reference of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2199-44-2) here.

Luminescence study of the reaction of 3,3′-methanediylbis(2,4,7,8,9-pentamethyldipyrrolylmethene) (H2L) with a number of metal salts showed that this compound is an efficient fluorescent chemosensor for Zn2+ ions in organic solvents. The selectivity and sensitivity of H2L were estimated in various solvents in the presence of other metal cations (Na+, Mg2+, Co2+, Ni2+, Cu2+, Cd2+, Hg2+, Pb2+).

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COA of Formula: C7H4ClN3O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole, is researched, Molecular C7H4ClN3O2, CAS is 15965-55-6, about Heterocyclic betaines. XXII. Azinium(azolium) 4-nitrobenzimidazolate inner salts and their derivatives with several interannular spacers. Synthesis, characterization and antitrichomonal activity. Author is Alcalde, Ermitas; Perez-Garcia, Lluiesa; Dinares, Immaculada; Frigola, Jordi.

The synthesis of an ensemble of pyridinium(imidazolium) 4-nitrobenzimidazolate betaines and their derivatives with several interannular linkages has been explored. Their antiprotozoal activity has also been examined

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