Tag: M.W:100-200

5908-62-3, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.5908-62-3, name is 1,1-Dioxo-isothiazolidine. Here is a downstream synthesis route of the compound 5908-62-3

Under a nitrogen atmosphere, a solution of 5-bromo-6-chloro-pyridine-2-carboxylic acid methyl ester (Example 9 c, 1 g, 4 mmol), isothiazolidine 1,1-dioxide (730 mg, 06 mmol), copper(I) iodide (150 mg, 0.8 mmol), 1,3-di(pyridin-2-yl)propane-1,3-dione (CAN 10198-89-7, 180 mg, 0.8 mmol) and potassium carbonate (1.1 g, 8 mmol) in DMF (20 mL) was reacted for 24 h at 110 C. The reaction mixture was poured into water, and extracted with ethyl acetate (3¡Á50 mL). The combined organic extracts were washed with water and brine, dried over anhydrous sodium sulfate and evaporated. The residue was purified by column chromatography (silica gel, 4 g, 10% ethyl acetate in petroleum ether) to yield the title compound (0.048 g, 1.6 mmol, 41.4%) as yellow solid; MS (EI): m/e=291.0 [M+H]+.

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 1,1-Dioxo-isothiazolidine, you can also browse my other articles.

Reference£º
Patent; Bissantz, Caterina; Grether, Uwe; Hebeisen, Paul; Kimbara, Atsushi; Liu, Qingping; Nettekoven, Matthias; Prunotto, Marco; Roever, Stephan; Rogers-Evans, Mark; Schulz-Gasch, Tanja; Ullmer, Christoph; Wang, Zhiwei; Yang, Wulun; US2012/316147; (2012); A1;,
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179087-93-5, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.179087-93-5, name is 2-(4-((2,4-Dioxothiazolidin-5-yl)methyl)phenoxy)acetic acid, below Introduce a new synthetic route.

Step 2-1-(1,1-dioxo-isothiazolidin-2-ylmethyl)-3-benzyl-5-bromo-benzene (8B) A mixture of 8A (5 g, 14.7 mmol), 1,3-propanesultam (3.6 g, 29.7 mmol) and potassium carbonate (4.1 g, 29.7 mmol) in acetonitrile (60 mL) was refluxed overnight. The solvent was removed under reduced pressure. The residue was partitioned between ethyl acetate and brine. The organic phase was dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by flash chromatograph (ethyl acetate/hexanes) to give 8B as a white solid.

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 5908-62-3, We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; Zhuang, Linghang; Wai, John S.; Payne, Linda S.; Young, Steven D.; Fisher, Thorsten E.; Embrey, Mark W.; Guare, James P..; US2005/10048; (2005); A1;,
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26364-65-8, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.26364-65-8, name is 2-Cyanoimino-1,3-thiazolidine, below Introduce a new synthetic route.

1, 3-propanesultam (72 mg, 0.60 MMOL) in anhydrous DMF (3 mL) was added under N2 to 60 % NaH in mineral oil (36 mg, 0.90 MMOL). The mixture was stirred for 20 min, then the compound prepared in Preparative Example 196 (200 mg, 0.46 MMOL) was added. The mixture was stirred at 100 C for 30 min, the solvent was evaporated and the residue was purified by flash chromatography using EtOAc as eluent to yield colorless solid (150 mg, 63%). LCMS : M+=523.

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 1,1-Dioxo-isothiazolidine, We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; SCHERING CORPORATION; PHARMACOPEIA, INC.; WO2004/22561; (2004); A1;,
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One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level.1438-16-0, name is 3-Aminorhodanine, introduce a new downstream synthesis route. , 1438-16-0

General procedure: Thiazolidin-2-ylidene-cyanamide (0.317 g, 2.50 mmol) inacetonitrile (20 mL) was dropwise added to a stirred solutionof substituted benzyl bromide (2.5 mmol) and 14 mL NaOHaqueous solution (1 M). The mixture is stirred at room temperaturefor 8-10 h. The soild was collected by filtration,washed with n-hexane and dried in vacuo., 26364-65-8

Thank you very much for taking the time to read this article. If you are also interested in other aspects of 26364-65-8, you can also browse my other articles.

Reference£º
Article; Jia, Ai-Quan; Ma, Sen; Wang, Jun-Ling; Zhang, Qian-Feng; Journal of Chemical Crystallography; (2020);,
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7025-19-6, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.7025-19-6, name is 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid, below Introduce a new synthetic route.

General procedure: O-phenylenediamines (0.065 mol) was heated with N-aminorhodanine (0.065 mol) in xylene (50 ml) for 5 hours. The obtained residue was filtered and was crystallized from aqueous alcohol (charcoal). The obtained solid was recrystallized in ethanol., 1438-16-0

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 3-Aminorhodanine, We look forward to the emergence of more reaction modes in the future.

Reference£º
Article; El Kihel; Ait Sir; Jebbari; Ahbala; Guesmi; Bauchat; Oriental Journal of Chemistry; vol. 32; 4; (2016); p. 1765 – 1768;,
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A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.7025-19-6, name is 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid. An updated downstream synthesis route of 7025-19-6 as follows., 7025-19-6

A mixture of 2-(4-bromophenyl)-6-cyclobutyl-5,6,7,8-tetrahydro-4H-[1 ,3]thiazolo[4,5- ofjazepine (may be prepared as described in Example 2) (57.0mg, 0.16mmol), isothiazolidine 1 ,1 -dioxide (38.0mg, 0.31 mmol), cesium carbonate (78.0mg, 0.24mmol), tris(dibenzylideneacetone)dipalladium(0) (7.00mg, 0.00deltammol), and 4,5- bis(diphenylphosphino)-9,9-dimethyl-xanthene (Xantphos) (14.0mg, 0.024mmol) in 1 ,4- dioxane (3ml) was heated under argon at 1060C for 3 hours. The reaction was then cooled to room temperature, diluted with methanol and passed down an ion exchange cartridge (SCX) and washed with methanol and then a 2M ammonia in methanol solution. The basic fractions were then reduced and purified using silica gel chromatography, eluting with a mixture of 2M ammonia in methanol and dichloromethane (1-2.5%) to afford the product (E99); MS (ES+) m/e 404 [M+H]+.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 1,1-Dioxo-isothiazolidine

Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/97691; (2006); A1;,
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1438-16-0, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.1438-16-0, name is 3-Aminorhodanine, below Introduce a new synthetic route.

General procedure: Thiazolidin-2-ylidene-cyanamide (0.317 g, 2.50 mmol) inacetonitrile (20 mL) was dropwise added to a stirred solutionof substituted benzyl bromide (2.5 mmol) and 14 mL NaOHaqueous solution (1 M). The mixture is stirred at room temperaturefor 8-10 h. The soild was collected by filtration,washed with n-hexane and dried in vacuo.

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 2-Cyanoimino-1,3-thiazolidine, We look forward to the emergence of more reaction modes in the future.

Reference£º
Article; Jia, Ai-Quan; Ma, Sen; Wang, Jun-Ling; Zhang, Qian-Feng; Journal of Chemical Crystallography; (2020);,
Thiazolidine – Wikipedia
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1438-16-0, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.1438-16-0, name is 3-Aminorhodanine,below Introduce a new synthetic route.

General procedure: To a reaction vessel was added compound19(70 mg, 0.16 mmol), thiazolidine-2,5-dione (28 mg, 0.25 mmol), piperidine (2 muL, 0.02 mmol) and acetic acid (1 muL, 0.02 mmol) in the presence of toluene. The reaction mixture was refluxed overnight and the reaction solvent was removed by evaporation. The residual was dissolved in EtOAc and washed with H2O (2 x 10 mL) and brine. The organic layer was collected, dried over anhydrous Na2SO4, filtered, concentrated and purifiedby silica gel column chromatography using 20% EtOAc in hexanes to afford compound20(57 mg, 66%).

Any one of these steps may be slow and thus may serve as the rate determining step. In general, however, in the presence of the catalyst, the overall rate of the reaction is faster than it would be if the reactants were in the gas or liquid phase.

Reference£º
Article; Kim, Hyojin; Cho, Suk Joon; Yoo, Minjin; Kang, Seung Kyu; Kim, Kwang Rok; Lee, Hwan Hee; Song, Jin Sook; Rhee, Sang Dal; Jung, Won Hoon; Ahn, Jin Hee; Jung, Jae-Kyung; Jung, Kwan-Young; Bioorganic and Medicinal Chemistry Letters; vol. 27; 23; (2017); p. 5213 – 5220;,
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5908-62-3, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.5908-62-3, name is 1,1-Dioxo-isothiazolidine, below Introduce a new synthetic route.

B. Preparation of 5-[[3-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-3-amino-2-thioxo-4-thiazolidinone The benzaldehyde intermediate from Example 77A (20.0 g; 112.2 mmol), N-aminorhodanine (18.29 g; 123.4 mmol) and sodium acetate (36.8 g; 448.8 mmol) were suspended in 560 ml of acetic acid. The suspension was heated to reflux, stirred at that temperature for 7 hours (at which time a precipitate had formed) and then cooled to room temperature with stirring. The precipitate was recovered by filtration and then washed successively with a 1:1 ethyl acetate/diethyl ether solution then a diethyl ether wash. The recovered precipitate was dried under vacuum at 60 C. for 2 hours to provide 14.5 g of the desired subtitled intermediate. m.p. >225 C., 1438-16-0

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 3-Aminorhodanine, We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; Eli Lilly and Company; US5731336; (1998); A;,
Thiazolidine – Wikipedia
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1438-16-0, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.1438-16-0, name is 3-Aminorhodanine. Here is a downstream synthesis route of the compound 1438-16-0

5908-62-3, PREPARATION 19 STR75 (This is an alternative to the method of Preparation 2). A mixture of 4-vinylpyridine (324 g), isothiazolidine-1,1-dioxide (373 g), and “Triton B” solution (129 ml, 40% w/v in methanol) was heated in D.M.F. at 50-55 for 7 hours. The reaction mixture was then concentrated under vacuum, water (2.52 liters) was added, and the product was extracted into CH2 Cl2 (3*1.87 liters). The combined methylene chloride extracts were washed with water and then evaporated to dryness. The residue was dissolved in ethyl acetate (1.3 liters) at 35 and hexane (0.87 liters) was added over 10 minutes. The resulting crystalline product was granulated at -5 to 0 for 4 hours, filtered, washed with hexane (0.37 liters) and dried in vacuum at 25, to give 2-[2-(4-pyridyl)ethyl]isothiazolidine-1,1-dioxide (518 g). The material was confirmed by n.m.r., i.r. and m.p. to be identical in all respects to the product of Preparation 2.

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 1,1-Dioxo-isothiazolidine, you can also browse my other articles.

Reference£º
Patent; Pfizer Inc.; US4489075; (1984); A;,
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