Tag: M.W=150-200

Safety of 1,1,1-Triethoxyethane. In 2020.0 RUSS J ORG CHEM+ published article about BIOLOGICAL EVALUATION; DERIVATIVES in [Paronikyan, E. G.; Dashyan, Sh. Sh.; Mamyan, S. S.] Natl Acad Sci Armenia, Sci & Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia in 2020.0, Cited 10.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7.

A method for the synthesis of derivatives of 8-hydrazino 6-thioxopyrano[3,4-c]pyridine has been developed. Derivatives of 8-hydrazino-6-(methylsulfanyl)pyrano[3,4-c]pyridines and 5-(or 3)-(alkylsulfanyl)pyrano[3,4-c][1,2,4]triazolo[4,3-a]pyridines have been synthesized. The thione-thiol tautomerism of 5-thioxopyrano[3,4-c][1,2,4]triazolo[4,3-a]pyridine has been studied. In a basic medium, the equilibrium shifts toward the thiol form, which has allowed synthesis ofS-alkyl-substituted triazolo[4,3-a]pyridines.

About 1,1,1-Triethoxyethane, If you have any questions, you can contact Paronikyan, EG; Dashyan, SS; Mamyan, SS or concate me.. Name: 1,1,1-Triethoxyethane

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recommanded Product: 78-39-7. Authors Huang, TW; Nagayama, M; Matsuda, J; Sasaki, K; Hayashi, A in MDPI published article about in [Huang, Ting-Wei; Sasaki, Kazunari; Hayashi, Akari] Kyushu Univ, Dept Hydrogen Energy Syst, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan; [Nagayama, Mayumi; Sasaki, Kazunari; Hayashi, Akari] Kyushu Univ, COI C2RSC, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan; [Matsuda, Junko; Sasaki, Kazunari; Hayashi, Akari] Kyushu Univ, Int Res Ctr Hydrogen Energy, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan; [Sasaki, Kazunari; Hayashi, Akari] Kyushu Univ, NEXT FC, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan; [Hayashi, Akari] Kyushu Univ, Q PIT, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan in 2021.0, Cited 38.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7

To improve the properties of mesoporous carbon (MC), used as a catalyst support within electrodes, MC fibers (MCFs) were successfully synthesized by combining organic-organic self-assembly and electrospinning deposition and optimizing heat treatment conditions. The pore structure was controlled by varying the experimental conditions. Among MCFs, MCF-A, which was made in the most acidic condition, resulted in the largest pore diameter (4-5 nm), and the porous structure and carbonization degree were further optimized by adjusting heat treatment conditions. Then, since the fiber structure is expected to have an advantage when MCFs are applied to devices, MCF-A layers were prepared by spray printing. For the resistance to compression, MCF-A layers showed higher resistance (5.5% change in thickness) than the bulk MC layer (12.8% change in thickness). The through-plane resistance was lower when the fiber structure remained more within the thin layer, for example, +8 m omega for 450 rpm milled MCF-A and +12 m omega for 800 rpm milled MCF-A against the gas diffusion layer (GDL) 25BC carbon paper without a carbon layer coating. The additional advantages of MCF-A compared with bulk MC demonstrate that MCF-A has the potential to be used as a catalyst support within electrodes in energy devices.

Recommanded Product: 78-39-7. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Huang, TW; Nagayama, M; Matsuda, J; Sasaki, K; Hayashi, A or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

HPLC of Formula: C8H18O3. In 2019.0 MOLECULES published article about LINE CACO-2; CAPSINOIDS; MECHANISMS; RECEPTOR in [Lieder, Barbara; Hans, Joachim; Hentschel, Fabia; Geissler, Katrin; Ley, Jakob] Symrise AG, Muehlenfeldstr 1, D-53479 Holzminden, Germany; [Lieder, Barbara] Univ Vienna, Dept Physiol Chem, CDL Taste Res, Althanstr 14, A-1090 Vienna, Austria in 2019.0, Cited 24.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7.

With raising prevalence of obesity, the regulation of human body fat is increasingly relevant. The modulation of fatty acid uptake by enterocytes represents a promising target for body weight maintenance. Recent results demonstrated that the trigeminal active compounds capsaicin, nonivamide, and trans-pellitorine dose-dependently reduce fatty acid uptake in differentiated Caco-2 cells as a model for the intestinal barrier. However, non-pungent alternatives have not been investigated and structural determinants for the modulation of intestinal fatty acid uptake have not been identified so far. Thus, based on the previous results, we synthesized 23 homovanillic acid esters in addition to the naturally occurring capsiate and screened them for their potential to reduce intestinal fatty acid uptake using the fluorescent fatty acid analog Bodipy-C12 in differentiated Caco-2 cells as an enterocyte model. Whereas pre-incubation with 100 mu M capsiate did not change fatty acid uptake by Caco-2 enterocytes, a maximum inhibition of -47% was reached using 100 mu M 1-methylpentyl-2-(4-hydroxy-3-methoxy-phenyl)acetate. Structural analysis of the 24 structural analogues tested in the present study revealed that a branched fatty acid side chain, independent of the chain length, is one of the most important structural motifs associated with inhibition of fatty acid uptake in Caco-2 enterocytes. The results of the present study may serve as an important basis for designing potent dietary inhibitors of fatty acid uptake.

HPLC of Formula: C8H18O3. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Lieder, B; Hans, J; Hentschel, F; Geissler, K; Ley, J or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In 2020.0 NAT PROD RES published article about NATURAL-PRODUCTS; STEREOCHEMISTRY in [Koziol, Agata; Fratczak, Jakub; Grela, Ewa; Lochynski, Stanislaw] Wroclaw Univ Sci & Technol, Fac Chem, Dept Bioorgan Chem, Wroclaw, Poland; [Koziol, Agata; Lochynski, Stanislaw] Acad Physiotherapy Wroclaw, Inst Cosmetol, Wroclaw, Poland; [Szczepanik, Maryla] Nicolaus Copernicus Univ, Dept Invertebrate Zool, Torun, Poland; [Gabrys, Beata; Dancewicz, Katarzyna] Univ Zielona Gora, Fac Biol Sci, Dept Bot & Ecol, Zielona Gora, Poland in 2020.0, Cited 16.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7. COA of Formula: C8H18O3

Terpenoid derivatives, which contain a preserved carane system in their structure, exhibit a broad spectrum of biological activities. Among them, we can distinguish insecticides, structures with pharmacological application etc. In the presented paper, the substrate – (-)-cis-caran-trans-4-ol was transformed using the reactions of typical organic synthesis to obtain novel derivatives. Most importantly, bromolactone ((-)-(1R,4R,6S)-2′-(bromomethyl)-4,7,7-trimethylspiro[bicyclo[4.1.0]heptan-3,3′-furan]-5′(4’H)-one) with the preserved carane system was synthesized. This bromolactone was tested for antifeedant activity against the lesser mealworm, Alphitobius diaperinus Panzer, and peach potato aphid (Myzus persicae). In addition, its moderate antibacterial activity was observed against the Bacillus subtilis strain (with Minimal Inhibitory Concentration of 200 mu g/mL).

COA of Formula: C8H18O3. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Koziol, A; Fratczak, J; Grela, E; Szczepanik, M; Gabrys, B; Dancewicz, K; Lochynski, S or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Synthesis and properties of gem-dinitro energetic salts based on 1,2,4-oxadiazole with low impact sensitivity WOS:000609189100004 published article about HIGH-NITROGEN; DERIVATIVES; EXPLOSIVES in [Lu, Tian; He, Yuna; Song, Jia; Hou, Zhengwen; Yin, Hongquan; Chen, Fu-Xue] Beijing Inst Technol, Sch Chem Sc Chem Engn, Liangxiang Campus,8 Liangxiang East Rd, Beijing 102488, Peoples R China; [Fan, Guijuan] CAEP, Inst Chem Mat, Mianyang 621050, Sichuan, Peoples R China in 2021.0, Cited 37.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7. COA of Formula: C8H18O3

Eight energetic salts with a gem-dinitro group based on 1,2,4-oxadiazole were developed. All of the structures were confirmed by infrared (IR) spectroscopy, H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopy, and high-resolution mass spectrometry (HRMS), and single-crystal X-ray diffraction was used to determine the structures of the pivotal intermediate 3-(chlorodinitromethyl)-5-methyl-1,2,4-oxadiazole (3), the potassium salt (4) and the hydrazinium salt (7). All of them are insensitive to impact (>40 J) and have higher energy levels than trinitrotoluene (TNT).

COA of Formula: C8H18O3. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Lu, T; He, YN; Song, J; Hou, ZW; Yin, HQ; Fan, GJ; Chen, FX or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recommanded Product: 78-39-7. In 2020.0 J MED CHEM published article about MORPHINE-TOLERANCE; PHYSICAL-DEPENDENCE; EFFICACY; PERMEABILITY; ANALGESICS; SOLUBILITY; MANAGEMENT; NALOXONE; PEPTIDE; BINDING in [Vekariya, Rakesh H.; Ray, Abhisek; Saini, Surendra K.; Zhang, Sixue; Ananthan, Subramaniam] Southern Res, Chem Dept, Birmingham, AL 35205 USA; [Lei, Wei; Molnar, Gabriella; Karlage, Kelly L.; Bilsky, Edward J.; Largent-Milnes, Tally M.; Streicher, John M.] Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85724 USA; [Barlow, Deborah; Houseknecht, Karen L.] Univ New England, Coll Osteopath Med, Dept Biomed Sci, Biddeford, ME 04005 USA in 2020.0, Cited 65.0. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7.

We previously identified a pyridomorphinan (6, SRI-22138) possessing a 4-chlorophenyl substituent at the 5′-position on the pyridine and a 3-phenylpropoxy at the 14-position of the morphinan as a mixed mu opioid receptor (MOR) agonist and delta/kappa opioid receptor (DOR/KOR) antagonist with potent antinociceptive activity and diminished tolerance and dependence in rodents. Structural variations at the 5′- and 14-positions of this molecule gave insights into the structure-activity relationships for binding and functional activity. Subtle structural changes exerted significant influence, particularly on the ability of the compounds to function as agonists at the MOR. In vivo evaluation identified compound 20 (SRI-39067) as a MOR agonist/DOR antagonist that produced systemically active potent antinociceptive activity in tail-flick assay in mice, with diminished tolerance, dependence/withdrawal, reward liability, and respiratory depression versus morphine. These results support the hypothesis that mixed MOR agonist/DOR antagonist ligands may emerge as novel opioid analgesics with reduced side effects.

Recommanded Product: 78-39-7. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Vekariya, RH; Lei, W; Ray, A; Saini, SK; Zhang, SX; Molnar, G; Barlow, D; Karlage, KL; Bilsky, EJ; Houseknecht, KL; Largent-Milnes, TM; Streicher, JM; Ananthan, S or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Wang, ZJ; Chen, WT; He, C; Zhang, GL; Yu, YP in GEORG THIEME VERLAG KG published article about QUINAZOLINE DERIVATIVES; INHIBITORS; NITRILES in [Wang, Zijuan; Chen, Wenteng; He, Chang; Zhang, Guolin; Yu, Yongping] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, 866 Yuhangtang Rd,Zijin Campus, Hangzhou 310058, Peoples R China in 2021.0, Cited 29.0. Name: 1,1,1-Triethoxyethane. The Name is 1,1,1-Triethoxyethane. Through research, I have a further understanding and discovery of 78-39-7

A one-pot method for joining three separate components leading to an assortment of 4-arylquinazolines (27 examples) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed- cascade reaction involving C(sp)-C(sp(2)) coupling followed by intramolecular C-N bond formation. The reaction was readily scaled up to gram quantity and successfully applied to the synthesis of a translocator- protein (TSPO) ligand.

Name: 1,1,1-Triethoxyethane. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Wang, ZJ; Chen, WT; He, C; Zhang, GL; Yu, YP or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recently I am researching about BIOLOGICAL EVALUATION; 2-SUBSTITUTED BENZOXAZOLES; SYNTHETIC METHODOLOGY; CARBOXYLIC-ACIDS; DERIVATIVES; BENZIMIDAZOLES; INHIBITORS; BENZOTHIAZOLES; TUBERCULOSIS; DISCOVERY, Saw an article supported by the Department of Pharmaceuticals (DoP), New Delhi; University Grants Commission (UGC), New DelhiUniversity Grants Commission, India. Computed Properties of C8H18O3. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Jadhavar, PS; Patel, KI; Dhameliya, TM; Saha, N; Vaja, MD; Krishna, VS; Sriram, D; Chakraborti, AK. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane

In search for new molecular entities as anti-TB agents, the benzimidazoquinazoline polyheterocyclic scaffold has been designed adopting the scaffold hopping strategy. Thirty-two compounds have been synthesized through an improved tandem decarboxylative nucleophilic addition cyclocondensation reaction of o-phenylenediamine with isatoic anhydride followed by further cyclocondensation of the intermediately formed 2-(o-aminoaryl) benzimidazole with trialkyl orthoformate/acetate. The resultant benzimidazoquinazolines were evaluated in vitro for anti-TB activity against M. tuberculosis H37Rv (ATCC27294 strain). Fourteen compounds exhibiting MIC values in the range of 0.4-6.25 mu g/mL were subjected to cell viability test against RAW 264.7 cell lines and were found to be non-toxic (< 30% inhibition at 50 mu g/mL). The active compounds were further evaluated against INH resistant Mtb strains. The most active compound 6x [MIC (H37Rv) of 0.4 mu g/mL] and the compound 6d [MIC (H37Rv) of 0.78 mu g/mL] were also found to be active against INH resistant Mtb strain with MIC values of 12.5 and 0.78 mu g/mL, respectively. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Jadhavar, PS; Patel, KI; Dhameliya, TM; Saha, N; Vaja, MD; Krishna, VS; Sriram, D; Chakraborti, AK or concate me.. Computed Properties of C8H18O3

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Discovery of [1,2,4]triazolo[4,3-a]pyrazine derivatives bearing a 4-oxo-pyridazinone moiety as potential c-Met kinase inhibitors published in 2020.0. Name: 1,1,1-Triethoxyethane, Reprint Addresses Zheng, PW; Zhu, WF (corresponding author), Jiangxi Sci & Technol Normal Univ, Sch Pharm, Jiangxi Prov Key Lab Drug Design & Evaluat, 605 Fenglin Rd, Nanchang 330013, Jiangxi, Peoples R China.. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane

Two series of [1,2,4]triazolo[4,3-a]pyrazine derivatives bearing 4-oxo-pyridazinone moieties (compounds 21a-l and 22a-l) were designed and their IC50 values were evaluated against three cancer cell lines (A549, MCF-7 and HeLa) and c-Met kinase. Among them, the compound with most potential, 22i, exhibited excellent anti-tumor activity against A549, MCF-7 and HeLa cancer cell lines with IC50 values of 0.83 +/- 0.07 mu M, 0.15 +/- 0.08 mu M and 2.85 +/- 0.74 mu M, respectively, and it also possessed superior c-Met kinase inhibition ability at the nanomolar level (IC50 = 48 nM). Moreover, dose-dependent experiments, AO fluorescence staining, cell cycle assay, Annexin V-FITC/PI staining and docking studies were carried out in this study. The results demonstrated that compound 22i could be a potential c-Met kinase inhibitor.

Name: 1,1,1-Triethoxyethane. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Zhang, BL; Liu, XB; Xiong, HH; Zhang, Q; Sun, X; Yang, ZH; Xu, S; Zheng, PW; Zhu, WF or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recently I am researching about MORPHINE-TOLERANCE; PHYSICAL-DEPENDENCE; EFFICACY; PERMEABILITY; ANALGESICS; SOLUBILITY; MANAGEMENT; NALOXONE; PEPTIDE; BINDING, Saw an article supported by the National Institute on Drug Abuse (NIDA) of the National Institutes of Health (NIH) [R01DA038635]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Vekariya, RH; Lei, W; Ray, A; Saini, SK; Zhang, SX; Molnar, G; Barlow, D; Karlage, KL; Bilsky, EJ; Houseknecht, KL; Largent-Milnes, TM; Streicher, JM; Ananthan, S. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane. Computed Properties of C8H18O3

We previously identified a pyridomorphinan (6, SRI-22138) possessing a 4-chlorophenyl substituent at the 5′-position on the pyridine and a 3-phenylpropoxy at the 14-position of the morphinan as a mixed mu opioid receptor (MOR) agonist and delta/kappa opioid receptor (DOR/KOR) antagonist with potent antinociceptive activity and diminished tolerance and dependence in rodents. Structural variations at the 5′- and 14-positions of this molecule gave insights into the structure-activity relationships for binding and functional activity. Subtle structural changes exerted significant influence, particularly on the ability of the compounds to function as agonists at the MOR. In vivo evaluation identified compound 20 (SRI-39067) as a MOR agonist/DOR antagonist that produced systemically active potent antinociceptive activity in tail-flick assay in mice, with diminished tolerance, dependence/withdrawal, reward liability, and respiratory depression versus morphine. These results support the hypothesis that mixed MOR agonist/DOR antagonist ligands may emerge as novel opioid analgesics with reduced side effects.

Computed Properties of C8H18O3. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Vekariya, RH; Lei, W; Ray, A; Saini, SK; Zhang, SX; Molnar, G; Barlow, D; Karlage, KL; Bilsky, EJ; Houseknecht, KL; Largent-Milnes, TM; Streicher, JM; Ananthan, S or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com