Tag: M.W=200-250

Quality Control of Chalcone. Charvieux, A; Vu, ND; Duguet, N; Lemaire, M in [Charvieux, Aubin; Nam Duc Vu; Duguet, Nicolas; Lemaire, Marc] Univ Claude Bernard Lyon1, Univ Lyon, CNRS,UMR 5246, INSA,CPE Lyon,ICBMS,Equipe CAtalyse SYnthese & EN, Batiment Lederer,1 Rue Victor Grignard, F-69100 Villeurbanne, France published Valorization of Methyl Azelaaldehydate – A Vegetable Oil Based Platform Molecule for the Synthesis of Monomers through Stetter Reaction in 2019.0, Cited 94.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

The valorization of vegetable oil-derived methyl azelaaldehydate (methyl 9-oxo-nonanoate) to monomers was studied through NHC-catalysed Stetter reaction. Among the Michael acceptors tested, dimethyl fumarate gave the highest selectivity (97 %) for the corresponding Stetter adduct, thus limiting the competing benzoin condensation.

Quality Control of Chalcone. About Chalcone, If you have any questions, you can contact Charvieux, A; Vu, ND; Duguet, N; Lemaire, M or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Magnetite nanoparticles functionalized with propolis against methicillin resistant strains of Staphylococcus aureus WOS:000479020700004 published article about IRON-OXIDE NANOPARTICLES; BIOLOGICAL-PROPERTIES; ANTIOXIDANT; AGENT in [El-Guendouz, Soukaina] Univ Sidi Mohamed Ben Abdallah, Fac Sci Dhar El Mehraz, Lab Physiol Pharmacol & Environm Hlth, BP 1796 Atlas, Fes 30000, Morocco; [El-Guendouz, Soukaina; Lyoussi, Badiaa; Miguel, Maria G.] Univ Algarve, Fac Sci & Technol, Dept Chem & Pharm, MeditBio, Campus Gambelas, P-8005139 Faro, Portugal; [Lourenco, Joao P.; Rosa da Costa, Ana M.] Univ Algarve, Fac Sci & Technol, Algarve Chem Res Ctr CIQA, Dept Chem & Pharm, P-8005139 Faro, Portugal; [Lourenco, Joao P.] Univ Lisbon, Inst Super Tecn, CQE, Ave Rovisco Pais, P-1049001 Lisbon, Portugal; [Dias, Cristina Barrocas; Manhita, Ana] Univ Evora, HERCULES Lab, Largo Marques de Marialva 8, P-7000809 Evora, Portugal; [Dias, Cristina Barrocas] Univ Evora, Sch Sci & Technol, Dept Chem, Rua Romao Ramalho 59, P-7000671 Evora, Portugal; [Jordao, Luisa] Inst Nacl Salide Doutor Ricardo Jorge INSA, DSA, UID L, Lisbon, Portugal; [Nogueira, Isabel] Inst Super Tecn, MicroLab, Ave Rovisco Pais, P-1049001 Lisbon, Portugal; [Faleiro, Maria L.] Univ Algarve, Ctr Biomed Res, Fac Sci & Technol, Dept Biol Sci & Bioengn, P-8005139 Faro, Portugal in 2019.0, Cited 28.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Category: thiazolidines

Magnetite nanoparticles (MNPs) have been evaluated for inhibiting microbial growth and biofilm formation. In this study the effect of the nanocomposite Moroccan propolis extract / MNPs acting against methicillin resistant strains of Staphylococcus aureus (MRSA) was evaluated. Chemical composition of propolis was established by pyrolysis coupled to gas chromatography and mass spectrometry method (pyrolysis GC/MS). MNPs were obtained through the co-precipitation method. The fabricated nanostructure was characterized by X-ray Diffraction (DRX), Transmission Electron Microscopy (TEM), and Fourier Transform-Infrared Spectroscopy (FTIR). TEM of MNPs provided a particle average size of 15 nm, FTIR spectral analysis enabled a fast way of identification of MNPs, attesting the occurrence of the different combinations. The use of MNPs loaded with propolis and the antibiotic chloramphenicol at Minimum Inhibitory Concentration (MIC) value inhibited the bacterial growth of MSSA (methicillin susceptible strain of S. aureus) and MRSA strains. After the treatment with MNPs-OA-P-CLo nanocomposite (MNPs with oleic acid, propolis and chloramphenicol), the disruption of the bacterial cell was observed by TEM. The combination of propolis and chloramphenicol in free form at MIC value largely impaired both MSSA and MRSA strains as, after 2 h of treatment, no viable cells of MRSA 2 and MRSA 16 were recovered. Hence, the results elucidated a new antibacterial nanocomposite synthesis, for possible applications as prospective nanoantibacterial agents or drug carriers. (C) 2019 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

Category: thiazolidines. About Chalcone, If you have any questions, you can contact El-Guendouz, S; Lyoussi, B; Lourenco, JP; da Costa, AMR; Miguel, MG; Dias, CB; Manhita, A; Jordao, L; Nogueira, I; Faleiro, ML or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Category: thiazolidines. Cui, HR; Guo, WB; Zhang, BB; Li, GP; Li, T; Yuan, YY; Zhang, N; Yang, YW; Feng, WW; Chu, FH; Wang, SL; Xu, B; Wang, PL; Lei, HM in [Cui, Herong; Guo, Wenbo; Zhang, Beibei; Li, Guoping; Li, Tong; Yuan, Yanyan; Zhang, Na; Yang, Yuwei; Chu, Fuhao; Xu, Bing; Wang, Penglong; Lei, Haimin] Beijing Univ Chinese Med, Sch Chinese Pharm, Beijing 102488, Peoples R China; [Feng, Wuwen] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 610000, Sichuan, Peoples R China; [Wang, Shenglan] Beijing Univ Chinese Med, Sch Acupuncture & Massage, Beijing 102488, Peoples R China published BA-12 Inhibits Angiogenesis via Glutathione Metabolism Activation in 2019.0, Cited 45.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

There is a need for an efficient and low-cost leading compound discovery mode. However, drug development remains slow, expensive, and risky. Here, this manuscript proposes a leading compound discovery strategy based on a combination of traditional Chinese medicine (TCM) formulae and pharmacochemistry, using a ligustrazine-betulinic acid derivative (BA-12) in the treatment of angiogenesis as an example. Blocking angiogenesis to inhibit the growth and metastasis of solid tumors is currently one recognized therapy for cancer in the clinic. Firstly, based on a traditional Prunella vulgaris plaster, BA-12 was synthesized according to our previous study, as it exhibited better antitumor activities than other derivatives on human bladder carcinoma cells (T24); it was then uploaded for target prediction. Secondly, the efficacy and biotoxicity of BA-12 on angiogenesis were evaluated using human umbilical vein endothelial cells (HUVECs), a quail chick chorioallantoic membrane, and Caenorhabditis elegans. According to the prediction results, the main mechanisms of BA-12 were metabolic pathways. Thus, multiple metabolomics approaches were applied to reveal the mechanisms of BA-12. Finally, the predictive mechanisms of BA-12 on glutathione metabolism and glycerophospholipid metabolism activation were validated using targeted metabolomics and pharmacological assays. This strategy may provide a reference for highly efficient drug discovery, with the aim of sharing TCM wisdom for unmet clinical needs.

Category: thiazolidines. About Chalcone, If you have any questions, you can contact Cui, HR; Guo, WB; Zhang, BB; Li, GP; Li, T; Yuan, YY; Zhang, N; Yang, YW; Feng, WW; Chu, FH; Wang, SL; Xu, B; Wang, PL; Lei, HM or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recommanded Product: Chalcone. In 2020.0 NAT PROD RES published article about INHIBITS MIGRATION; ISOFLAVAN GLABRIDIN; LICORICE ROOT; INVASION; ANGIOGENESIS; CELLS in [Kapkoti, Deepak Singh; Bhakuni, Rajendra Singh] CSIR Cent Inst Med & Aromat Plants, Med Chem Dept, Lucknow, Uttar Pradesh, India; [Singh, Shilpi; Luqman, Suaib] CSIR Cent Inst Med & Aromat Plants, Mol Bioprospect Dept, Lucknow, Uttar Pradesh, India; [Alam, Sarfaraz; Khan, Feroz] CSIR Cent Inst Med & Aromat Plants, Metab & Struct Biol Dept, Lucknow, Uttar Pradesh, India in 2020.0, Cited 19.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Novel Mannich base derivatives of glabridin were synthesized and their antiproliferative activity were performed along with our previously reported glabridin-chalcone hybrids molecules (GCHMs) against various human cell lines MDA-MB-231 (breast adenocarcinoma), HEK-293 (embryonic kidney cell line), K562 (leukemia), MCF-7 (breast adenocarcinoma), HeLa (cervix adenocarcinoma), HepG2 (hepatocellular carcinoma) and WRL-68 (hepatic carcinoma). The result showed that the glabridin significantly reduced cell proliferation with IC(50)ranges from 3.67 to 58.30 mu M against all the tested cell lines. The remarkable reduction in antiproliferative activity 2′,4′-dimethoxyglabridin and GCHMs compounds with phenolic OH groups protected by methoxy (OCH3) groups suggested that the free OH groups are essential factor for the antiproliferative activity of glabridin and its derivatives. The Mannich base derivatives of glabridin showed moderate activity IC50(2.20->95.78 mu M). Furthermore,in silicotarget identification analysis revealed that AKT1, DECR1 and NOS1 are the potential targets for glabridin and their derivatives.

Recommanded Product: Chalcone. About Chalcone, If you have any questions, you can contact Kapkoti, DS; Singh, S; Alam, S; Khan, F; Luqman, S; Bhakuni, RS or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In 2019.0 INT J MOL SCI published article about DRUG TARGET IDENTIFICATION; VASCULAR DEVELOPMENT; WEB SERVER; DIFFERENTIATION; BEVACIZUMAB; MECHANISMS; GROWTH; VEGF in [Cui, Herong; Guo, Wenbo; Zhang, Beibei; Li, Guoping; Li, Tong; Yuan, Yanyan; Zhang, Na; Yang, Yuwei; Chu, Fuhao; Xu, Bing; Wang, Penglong; Lei, Haimin] Beijing Univ Chinese Med, Sch Chinese Pharm, Beijing 102488, Peoples R China; [Feng, Wuwen] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 610000, Sichuan, Peoples R China; [Wang, Shenglan] Beijing Univ Chinese Med, Sch Acupuncture & Massage, Beijing 102488, Peoples R China in 2019.0, Cited 45.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Category: thiazolidines

There is a need for an efficient and low-cost leading compound discovery mode. However, drug development remains slow, expensive, and risky. Here, this manuscript proposes a leading compound discovery strategy based on a combination of traditional Chinese medicine (TCM) formulae and pharmacochemistry, using a ligustrazine-betulinic acid derivative (BA-12) in the treatment of angiogenesis as an example. Blocking angiogenesis to inhibit the growth and metastasis of solid tumors is currently one recognized therapy for cancer in the clinic. Firstly, based on a traditional Prunella vulgaris plaster, BA-12 was synthesized according to our previous study, as it exhibited better antitumor activities than other derivatives on human bladder carcinoma cells (T24); it was then uploaded for target prediction. Secondly, the efficacy and biotoxicity of BA-12 on angiogenesis were evaluated using human umbilical vein endothelial cells (HUVECs), a quail chick chorioallantoic membrane, and Caenorhabditis elegans. According to the prediction results, the main mechanisms of BA-12 were metabolic pathways. Thus, multiple metabolomics approaches were applied to reveal the mechanisms of BA-12. Finally, the predictive mechanisms of BA-12 on glutathione metabolism and glycerophospholipid metabolism activation were validated using targeted metabolomics and pharmacological assays. This strategy may provide a reference for highly efficient drug discovery, with the aim of sharing TCM wisdom for unmet clinical needs.

Category: thiazolidines. About Chalcone, If you have any questions, you can contact Cui, HR; Guo, WB; Zhang, BB; Li, GP; Li, T; Yuan, YY; Zhang, N; Yang, YW; Feng, WW; Chu, FH; Wang, SL; Xu, B; Wang, PL; Lei, HM or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Recommanded Product: 94-41-7. Recently I am researching about CATALYTIC ASYMMETRIC HYDROGENATION; P-N-P’; IRON(II) COMPLEXES; COBALT COMPLEXES; WELL, Saw an article supported by the F. Hoffmann-La Roche AGHoffmann-La Roche; Leibniz Foundation (Leibniz Competition) [SAW-2016-LIKAT-1]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Garbe, M; Wei, ZH; Tannert, B; Spannenberg, A; Jiao, HJ; Bachmann, S; Scalone, M; Junge, K; Beller, M. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

The synthesis of different metal pincer complexes coordinating to the chiral PNP ligand bis(2-((2R,5R)-2,5-dimethyl-phospholanoethyl))amine is described in detail. The characterized complexes with Mn, Fe, Re and Ru as metal centers showed good activities regarding the reduction of several prochiral ketones. Comparing these catalysts, the non-noble metal complexes produced best selectivities not only for aromatic substrates, but also for different kinds of aliphatic ones leading to enantioselectivities up to 99% ee. Theoretical investigations elucidated the mechanism and rationalized the selectivity.

Recommanded Product: 94-41-7. About Chalcone, If you have any questions, you can contact Garbe, M; Wei, ZH; Tannert, B; Spannenberg, A; Jiao, HJ; Bachmann, S; Scalone, M; Junge, K; Beller, M or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Diels-Alder route to norbornane derived vicinal phosphane/borane frustrated Lewis pairs for the metal-free catalytic hydrogenation of alpha, beta-unsaturated ketones WOS:000485104600004 published article about HETEROLYTIC DIHYDROGEN ACTIVATION; ELECTRONIC CONTROL; CHEMISTRY; REDUCTION; BIS(PENTAFLUOROPHENYL)BORANE; STEREOSELECTIVITY in [Woelke, Christian; Daniliuc, Constantin G.; Kehr, Gerald; Erker, Gerhard] Westfalische Wilhelms Univ Munster, Organ Chem Inst, Corrensstr 40, D-48149 Munster, Germany in 2019.0, Cited 56.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Product Details of 94-41-7

The [4+2] cycloaddition reaction of the (dimesitylphosphino) cyclopentadienes 5a,b with N-phenyl-maleimide gave the norbornene derivative 9. Its reduction with LiAlH4 produced the N-phenyl-pyrrolidino-annulated system 10. Treatment with Piers’ borane gave the respective P/B FLP 12 as the major product, which cleaved dihydrogen under mild conditions to yield the phosphonium/hydrido borate product 14. Reaction of the phosphino-norbornene 10 with 2 M equiv. of Piers’ borane [HB(C6F5)(2)] followed by exposure to dihydrogen eventually gave the HB(C6F5)(2) adduct 15. This served as a catalyst for the hydrogenation of a series of chalcone derivatives. The system requires a pre-activation period before becoming active for the conjugated enone hydrogenation. (C) 2019 Elsevier B.V. All rights reserved.

Product Details of 94-41-7. About Chalcone, If you have any questions, you can contact Wolke, C; Daniliuc, CG; Kehr, G; Erker, G or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Application In Synthesis of Chalcone. In 2021.0 MOL CATAL published article about METAL-ORGANIC FRAMEWORKS; TRANSFER HYDROGENATION; LEWIS-ACID; ALCOHOLS; ZR; MODULATION; NITRILES; OXIDES; SITES in [Lin, Yamei; Bu, Qingxia; Xu, Jiaxian; Liu, Xiao; Zhang, Xueping; Lu, Guo-Ping; Zhou, Baojing] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China; [Lin, Yamei] Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210032, Peoples R China in 2021.0, Cited 46.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Hf-MOF-808 exhibits excellent activity and specific selectivity on the hydrogenation of carbonyl compounds via a hydrogen transfer strategy. Its superior activity than other Hf-MOFs is attributed to its poor crystallinity, defects and large specific surface area, thereby containing more Lewis acid-base sites which promote this reaction. Density functional theory (DFT) computations are performed to explore the catalytic mechanism. The results indicate that alcohol and ketone fill the defects of Hf-MOF to form a six-membered ring transition state (TS) complex, in which Hf as the center of Lewis stearic acid coordinates with the oxygen of the substrate molecule, thus effectively promoting hydrogen transfer process. Other reactive groups, such as ?NO2, C = C, -CN, of inadequate hardness or large steric hindrance are difficult to coordinate with Hf, thus weakening their catalytic effect, which explains the specific selectivity Hf-MOF-808 for reducing the carbonyl group.

About Chalcone, If you have any questions, you can contact Lin, YM; Bu, QX; Xu, JX; Liu, X; Zhang, XP; Lu, GP; Zhou, BJ or concate me.. Application In Synthesis of Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

HPLC of Formula: C15H12O. I found the field of Chemistry very interesting. Saw the article Potassium Carbonate Promoted Nucleophilic Addition of Alkenes with Phosphites published in 2020.0, Reprint Addresses Guo, SM (corresponding author), Nanchang Univ, Dept Chem, Nanchang 330031, Jiangxi, Peoples R China.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone.

A facile hydrophosphonylation of alkenes by phosphites promoted by potassium carbonate was developed. The reaction features include easy handling, environmental friendliness, and avoidance of the use of strong bases. A variety of alkenes are tolerated in this reaction, with moderate to excellent yields.

HPLC of Formula: C15H12O. About Chalcone, If you have any questions, you can contact Huang, ZJ; Liu, W; Li, S; Yang, YT; Guo, SM; Cai, H or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Prediction of chalcone derivative cytotoxicity activity against MCF-7 human breast cancer cell by Monte Carlo method WOS:000458612300035 published article about BIOLOGICAL EVALUATION; GA-MLR; ANTICANCER; AGENTS; DOCKING; ANALOGS; DESIGN; MODEL; QSPR in [Ahmadi, Shahin] Islamic Azad Univ, Dept Chem, Kermanshah Branch, Kermanshah, Iran; [Mardinia, Fariba; Balali, Ebrahim] Islamic Azad Univ, Dept Chem, Fac Pharmaceut Chem, Tehran Med Sci, Tehran, Iran; [Azimi, Neda] Islamic Azad Univ, Dept Chem Engn, Kermanshah Branch, Kermanshah, Iran; [Qomi, Mahnaz] Islamic Azad Univ, Act Pharmaceut Ingredients Res APIRC, Tehran Med Sci, Tehran, Iran in 2019.0, Cited 43.0. Name: Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

The anticancer activity of chalcones and their analogs is the most important biological activity of them among their broad spectrum of their biological activity. In this investigation, we performed quantitative structure-activity relationship (QSAR) modeling of the anticancer activity of 134 chalcones and their analogs against MCF-7 human breast cancer cell lines using Monte Carlo method. QSAR models were calculated by CORAL software and optimal descriptors were calculated with SMILES and hydrogen suppressed molecular graph (HSG). The total dataset split into training, invisible training, calibration, and validation set randomly. Analysis of three probes of the Monte Carlo optimization with three random splits was done. Results from three random splits displayed robust, very simple, predictable, and reliable models for training, invisible training, calibration, and validation set with the correlation coefficient (R-2) of 0.8142-0.8244, 0.8244-0.8699, 0.8125-0.8627 and 0.8290-0.8686 respectively. As a result, the obtained models help to identify the hybrid descriptors for the increase and the decrease of anticancer activity of chalcones against MCF-7 human breast cancer cell lines. This simple QSAR model can be used for prediction of log IC50 of numerous chalcone derivatives against breast cancer cell. (C) 2019 Elsevier B.V. All rights reserved.

Name: Chalcone. About Chalcone, If you have any questions, you can contact Ahmadi, S; Mardinia, F; Azimi, N; Qomi, M; Balali, E or concate me.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com