Tag: M.W=200-250

Xia, YP; Ouyang, L; Liao, JH; Yang, X; Luo, RS in [Xia, Yanping; Ouyang, Lu; Liao, Jianhua; Yang, Xiao; Luo, Renshi] Gannan Med Univ, Sch Pharm, Ganzhou 341000, Jiangxi, Peoples R China published Chemoselective Transfer Hydrogenation of alpha,beta-Unsaturated Ketones Catalyzed by Iridium Complexes in 2021.0, Cited 72.0. Application In Synthesis of Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Efficient chemoselective transfer hydrogenation of the C=C bond of alpha,beta-unsaturated ketones has been developed, using the iridium complexes containing pyridine-imidazolidinyl ligands as catalysts and formic acid as a hydrogen source. In comparison with organic solvents or H2O as solvent, the mixed solvents of H2O and MeOH are critical for a high catalytic chemoselective transformation. This chemoselective transfer hydrogenation can be carried out in air, which is operationally simple, allowing a wide variety of alpha,beta-unsaturated substrates with different functional groups (electron-donating and electron-withdrawing substituents) leading to chemoselective transfer hydrogenation in excellent yields. The practical application of this protocol is demonstrated by a gram-scale transformation.

Application In Synthesis of Chalcone. Welcome to talk about 94-41-7, If you have any questions, you can contact Xia, YP; Ouyang, L; Liao, JH; Yang, X; Luo, RS or send Email.

Reference:
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I found the field of Pharmacology & Pharmacy very interesting. Saw the article New chalcone-type compounds and 2-pyrazoline derivatives: synthesis and caspase-dependent anticancer activity published in 2020. Category: thiazolidines, Reprint Addresses Boulebd, H (corresponding author), Univ Freres Mentouri Constantine, Fac Sci Exactes, Lab Prod Nat Origine Vegetale & Synthese Organ, Campus Chaabat Ersas, Constantine 25000, Algeria.; Pereira, DM (corresponding author), Univ Porto, Fac Farm, REQUIMTE LAQV, Lab Farmacognosia,Dept Quim, R Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal.; Silva, AMS (corresponding author), Univ Aveiro, QOPNA, P-3810193 Aveiro, Portugal.; Silva, AMS (corresponding author), Univ Aveiro, LAQV REQUIMTE, Dept Chem, P-3810193 Aveiro, Portugal.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

Aim: There is a continuous and urgent need for new anticancer agents with novel structures and target selectivity. Methods & results: The anticancer activity of the prepared compounds was assessed against human lung (A549) and stomach (AGS) cancer cell lines and evaluated in the noncancer human lung fibroblast (MRC-5) cell line. 2-Pyrazolines were devoid of toxicity in all cell lines used, chalcones bearing a beta-(benz)imidazole moiety being toxic toward AGS cell line. Mechanistic studies showed that these compounds trigger loss of cell viability and mitochondrial membrane potential, while eliciting morphological traits compatible with regulated cell death, which was ultimately shown to derive from caspase activation, specifically caspase-3. Conclusion: Chalcones 1-3 have been identified as new and promising anticancer agents toward the AGS cell line.

Welcome to talk about 94-41-7, If you have any questions, you can contact Chouiter, MI; Boulebd, H; Pereira, DM; Valentao, P; Andrade, PB; Belfaitah, A; Silva, AMS or send Email.. Category: thiazolidines

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Thiazolidine – Wikipedia,
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Recommanded Product: 94-41-7. Shoman, ME; Aboelez, MO; Shaykhon, MSA; Ahmed, SA; Abuo-Rahma, GEA; Elhady, OM in [Shoman, Mai E.; Abuo-Rahma, Gamal El-Din A.] Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt; [Aboelez, Moustafa O.] Sohag Univ, Fac Pharm, Dept Pharmaceut Chem, Sohag 82524, Egypt; [Shaykhon, Montaser Sh A.] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Chem, Assiut 71524, Egypt; [Ahmed, Sanaa A.] Sohag Univ, Fac Med, Dept Pharmacol, Sohag 82524, Egypt; [Elhady, Omar M.] Sohag Univ, Dept Chem, Sohag 82524, Egypt published New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity in 2021.0, Cited 33.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

Nicotinic acid hydrazide was incorporated into new 4,5-dihydro-5-hydroxy-3,5-diphenylpyrazol-1-yl derivatives. Compounds 6a-h were synthesized, and their antihyperlipidemic activity was evaluated in high cholesterol diet-fed rat model. Compounds 6e, 6f were found to decrease the levels of serum total cholesterol by 14-19% compared to control group. Total triglycerides were also reduced by 24-28% and LDL cholesterol by 16%. As expected from parent niacin, compounds 6e and 6f caused an elevation of HDL cholesterol by 33-41%. Docking study supported the ability of designed compounds to block NPC1L1 active site in a manner similar to that observed with ezetimibe.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In 2020.0 ACS APPL ENERG MATER published article about CARBON-DIOXIDE; CATALYZED CARBOXYLATION; SILICON NANOWIRES; BUILDING-BLOCK; HYDROCARBOXYLATION; ALKYNES; ACIDS; CONVERSION; REDUCTION; INSERTION in [Chen, Ruonan; Tian, Keyi; Yang, Ge; Xu, Jiafang; Chen, Hongyu; Zhang, Yanhua] Nanjing Tech Univ, Inst Adv Synth, Sch Chem & Mol Engn, Nanjing 211816, Jiangsu, Peoples R China; [He, Da; Gao, Tianyue; Wang, Dunwei] Boston Coll, Mercket Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA in 2020.0, Cited 39.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Recommanded Product: Chalcone

One-step synthesis of beta-carboxyl ketones from alpha,beta-unsaturated ketones using CO2 as a feedstock by photoelectro-synergetic catalysis is reported herein. In this ambient system, silica nanowires (SiNWs) electrode not only acts as the working electrode but also harvests extra light energy to promote the reaction. Following a possible two-step single-electron-transfer process, various substrates exhibit good efficiency with up to 98% product yield, and the method shows wide functional group tolerance.

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Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Chemoselective transfer hydrogenation of alpha,beta-unsaturated carbonyls catalyzed by a reusable supported Pd nanoparticles on biomass-derived carbon published in 2019.0. Application In Synthesis of Chalcone, Reprint Addresses Yang, Y (corresponding author), Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone

We herein report highly chemoselective transfer hydrogenation of alpha,beta-unsaturated carbonyl compounds to saturated carbonyls with formic acid as a hydrogen donor over a stable and recyclable heterogeneous Pd nano particles (NPs) on N,O-dual doped hierarchical porous biomass-derived carbon. The synergistic effect between Pd NPs and incorporated heteroatoms on carbon plays a critical role on promoting the reaction efficiency. A series of alpha,beta-aromatic and aliphatic unsaturated carbonyl compounds was selectively reduced to their corresponding saturated carbonyls in up to 97% isolated yields with good tolerance of various functional groups. In addition, the catalyst can be successively reused for at least 6 times without significant loss in reaction efficiency.

Welcome to talk about 94-41-7, If you have any questions, you can contact Song, T; Duan, YA; Yang, Y or send Email.. Application In Synthesis of Chalcone

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Synthesis, Antimicrobial and Antioxidant Activities of Pyrimidinyl Benzothiazine Carboxamides WOS:000471808200018 published article about GREEN APPROACH; AMINES; ULTRASOUND; ACID in [Tamatam, Rekha; Panga, Siva Sankar; Adivireddy, Padmaja; Venkatapuram, Padmavathi] Sri Venkateswara Univ, Dept Chem, Tirupati, Andhra Pradesh, India; [Grigory, Zyryanov, V; Gundala, Sravya; Nemallapudi, Bakthavatchala Reddy] Ural Fed Univ, Dept Organ & Biomol Chem, Ekaterinburg 620002, Russia; [Vasikarla, Kamala Prasad] Denisco Chem Pvt Ltd, Hyderabad 500055, Telangana, India in 2019.0, Cited 27.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Category: thiazolidines

A variety of pyrimidinyl benzothiazine carboxamides were prepared from benzothiazine carboxylate and 4,6-diaryl/heteroarylpyrimidinyl-2-amines. The compounds having 4-nitro phenyl, 4-pyridinyl and pyrazolyl – pyrimidinyl benzothiazine carboxamide moieties 6 e, 6 i, 6 j, 6 k and 6 m displayed prominent antibacterial activity against Bacillus subtilis. Further, compounds having pyrrolyl, pyrazolyl, pyridinyl and indolyl units 6 f, 6 k, 6 m and 6 n displayed prominent antifungal activity against Aspergillus niger. On the other hand, compounds with electron donating substituents on the aromatic ring (6 b, 6 c) and those with furan moiety (6 g, 6 h and 6 l) displayed very good free radical scavenging activity greater than Ascorbic acid.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Product Details of 94-41-7. I found the field of Chemistry; Science & Technology – Other Topics; Engineering very interesting. Saw the article In Situ Sulfidation of Pd/C: A Straightforward Method for Chemoselective Conjugate Reduction by Continuous Hydrogenation published in 2019.0, Reprint Addresses George, MW (corresponding author), Univ Nottingham, Sch Chem, Univ Pk, Nottingham NG7 2RD, England.; George, MW (corresponding author), Univ Nottingham Ningbo China, Dept Chem & Environm Engn, 199 Taikang East Rd, Ningbo 315100, Zhejiang, Peoples R China.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone.

A method has been developed for the in situ sulfidation of Pd/C under continuous flow. The approach provides a cheap, sustainable, and operationally convenient method for chemoselective conjugate reduction by continuous hydrogenation. High conversions and excellent selectivities were obtained for olefin reduction in alpha/beta-unsaturated carbonyl compounds in the presence of hydrogenatively sensitive functionalities. The methodology was analyzed with a green metric system to highlight the sustainability features of the process.

Welcome to talk about 94-41-7, If you have any questions, you can contact Moore, JC; Howie, RA; Bourne, SL; Jenkins, GN; Licence, P; Poliakoff, M; George, MW or send Email.. Product Details of 94-41-7

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Aegurla, B; Peddinti, RK in WILEY-V C H VERLAG GMBH published article about FRIEDEL-CRAFTS REACTIONS; ALLYLIC ALCOHOLS; NUCLEOPHILIC SUBSTITUTIONS; BENZYLIC ALCOHOLS; ALPHA-ALKYLATION; BOND ACTIVATION; METAL; BENZYLATION; GENERATION; INDOLES in [Aegurla, Balakrishna; Peddinti, Rama Krishna] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttarakhand, India in 2019.0, Cited 71.0. Computed Properties of C15H12O. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

A dehydrative C- and S-alkylation procedure by nucleophilic substitution of gamma-hydroxysufones with arenes and thiophenols is reported. This study represents an elegant and ecological concept to construct C-C and C-S bonds leading to unsymmetrical 1,1- and 3,3-branched propanes. The gamma-hydroxysufones underwent BF3 center dot OEt2-mediated dehydrative arylation and thiolation at room temperature and elimination at 40 degrees C. The nucleophile attack occurred on the less hindered side of a planar benzylic carbocation to furnish the title compounds with good diastereoselectivity.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Authors Guo, T; Xia, ROJ; Chen, M; He, J; Su, SJ; Liu, LW; Li, XY; Xue, W in ROYAL SOC CHEMISTRY published article about BACTERIAL LEAF-BLIGHT; ORYZAE PV. ORYZAE; ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY; MOLECULAR DOCKING; RESISTANCE GENES; DESIGN; ANTICANCER; HYBRIDS; CYTOTOXICITY in [Guo, Tao; Xia, Ronqjiao; Chen, Mei; He, Jun; Su, Shijun; Liu, Liwei; Li, Xiangyang; Xue, Wei] Guizhou Univ, Ctr Res & Dev Fine Chem, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,State Key Lab Breeding Base Green Pes, Guiyang 550025, Guizhou, Peoples R China in 2019.0, Cited 51.0. Recommanded Product: 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

A series of novel chalcone derivatives containing a thiophene sulfonate group were designed and synthesized. The structures of all title compounds were determined by H-1-NMR, C-13-NMR and HRMS. Antibacterial bioassays indicated that, compound 2l demonstrated excellent antibacterial activities against Xanthomonas axonopodis pv. citri (Xac), with an EC50 value of 11.4 mu g mL(-1), which is significantly superior to those of bismerthiazol (BT) (51.6 mu g mL(-1)) and thiodiazole-copper (TC) (94.7 mu g mL(-1)). Meanwhile, the mechanism of action of compound 2l was confirmed by using scanning electron microscopy (SEM). In addition, compound 2e showed remarkable inactivation activity against Tobacco mosaic virus (TMV), with an EC50 value of 44.3 mu g mL(-1), which was superior to that of ningnanmycin (120.6 mu g mL(-1)). Microscale thermophoresis (MST) also showed that the binding of compounds 2e and 2h to Tobacco mosaic virus coat protein (TMV-CP) yielded K-d values of 0.270 and 0.301 mu mol L-1, which are better than that of ningnanmycin (0.596 mu mol L-1). At the same time, molecular docking studies for 2e and 2h with TMV-CP (PDB code: ; 1EI7) showed that the compound was embedded well in the pocket between the two subunits of TMV-CP in each case. These results suggested that chalcone derivatives containing a thiophene sulfonate group may be considered as activators in the design of antibacterial and antiviral agents.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

An article Photocatalytic deaminative benzylation and alkylation of tetrahydroisoquinolines with N-alkylpyrydinium salts WOS:000527164500001 published article about SP(3) C-H; PYRIDINIUM SALTS; PHOTOREDOX CATALYSIS; ORGANIC-SYNTHESIS; BOND; FUNCTIONALIZATION; ACTIVATION; EFFICIENT; REAGENTS in [Schoenbauer, David; Schnuerch, Michael] TU Wien, Inst Appl Synthet Chem, Getreidemarkt 9-163, A-1060 Vienna, Austria; [Sambiagio, Carlo; Noel, Timothy] Eindhoven Univ Technol, Dept Chem Engn & Chem, Micro Flow Chem & Synthet Methodol, Den Dolech 2, NL-5612 AZ Eindhoven, Netherlands in 2020.0, Cited 52.0. Recommanded Product: Chalcone. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7

A ruthenium-catalyzed photoredox coupling of substituted N-aryltetrahydroisoquinolines (THIQs) and different bench-stable pyridinium salts was successfully developed to give fast access to 1-benzyl-THIQs. Furthermore, secondary alkyl and allyl groups were also successfully introduced via the same method. Additionally, the typically applied N-phenyl group in the THIQ substrate could be replaced by the cleavable p-methoxyphenyl (PMP) group and successful N-deprotection was demonstrated.

Recommanded Product: Chalcone. Welcome to talk about 94-41-7, If you have any questions, you can contact Schonbauer, D; Sambiagio, C; Noel, T; Schnurch, M or send Email.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com