Tag: M.W:200-300

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Nippon Kagaku Zasshi called Reactions of haloferrocenes with organolithium compounds, Author is Sonoda, Akio; Moritani, Ichiro, which mentions a compound: 1273-73-0, SMILESS is Br[C-]12[Fe+2]3456789([C-]%10C6=C7C8=C9%10)C1=C3C4=C25, Molecular C10BrFe, Reference of Bromoferrocene.

Reactions of BuLi or PhLi with chloroferrocene (I), 1,1′-dichloroferrocene (II), and bromoferrocene (III) were investigated. I (0.802 g) in 25 ml Et2O treated with 200 millimoles. BuLi in Et2O and quenched with H2O gave 0.033 g ferrocene (IV) and 0.534 g I. Lithiation of 0.870 g I followed by carbonation and esterification afforded 0.398 g Me 2-chloroferrocenecarboxylate (V) and 0.051 g di-Me 2-chloroferrocene-1,1′-dicarboxylate. Similarly I and PhLi gave 21% V. Heating I and PhLi 4.5 hr and quenching with H2O afforded 50% I, 8% IV, and 24% phenylferrocene (V). However no ferrocyne was detected in attempted capture with some dienes. Similarly lithiation of II followed by carbonation and esterification gave meso and racemic forms, m. 117-17.5° and 110-11°, of di-Me 2,2′-dichloroferrocenedicarboxylates in 48% yield. The reaction of III with BuLi at -78° followed by quenching with H2O gave 36% IV and 37% IV, whereas lithiation at room temperature gave 99% IV. Treating III with PhLi also afforded small amount of V. Lithiation at the 2-position is favored in the case of the Cl compound whereas Br-Li exchange is favored in the case of the Br compound I lithiated with BuLi and treated with HgBr2 gave bis(2-chloroferrocenyl)mercury (VI), m. 219-20°. Similarly bis(2,1′-dichloroferrocenyl)mercury was prepared Attempted capture of ferrocyne by heating VI in tetracyclone ended in failure, the product being IV.

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Reference:
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1428537-19-2, is researched, Molecular C13H15F3N2O, about Enantioselective construction of remote quaternary stereocentres, the main research direction is trisubstituted alkenyl alc arylboronic acid palladium relay Heck arylation; aryl carbonyl compound quaternary carbon substituted stereoselective preparation.Electric Literature of C13H15F3N2O.

Small mols. that contain all-carbon quaternary stereocenters-carbon atoms bonded to four distinct carbon substituents-are found in many secondary metabolites and some pharmaceutical agents. The construction of such compounds in an enantioselective fashion remains a long-standing challenge to synthetic organic chemists. In particular, methods for synthesizing quaternary stereocenters that are remote from other functional groups are underdeveloped. Here we report a catalytic and enantioselective intermol. Heck-type reaction of trisubstituted-alkenyl alcs. with aryl boronic acids. This method provides direct access to quaternary all-carbon-substituted β-, γ-, δ-, ε- or ζ-aryl carbonyl compounds, because the unsaturation of the alkene is relayed to the alc., resulting in the formation of a carbonyl group. The scope of the process also includes incorporation of pre-existing stereocenters along the alkyl chain, which links the alkene and the alc., in which the stereocenter is preserved. The method described allows access to diverse mol. building blocks containing an enantiomerically enriched quaternary center.

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Reference:
Thiazolidine – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Diferrocenylamine》. Authors are Nesmeyanov, A. N.; Sazonova, V. A.; Romanenko, V. I..The article about the compound:Bromoferrocenecas:1273-73-0,SMILESS:Br[C-]12[Fe+2]3456789([C-]%10C6=C7C8=C9%10)C1=C3C4=C25).Product Details of 1273-73-0. Through the article, more information about this compound (cas:1273-73-0) is conveyed.

N-Acetylferrocenylamine heated with excess EtONa 40 min. at 150° gave a red-brown Na derivative, which with bromoferrocene in the presence of CuBr 1 h. at 110-20° gave a mixture of ferrocene, diferrocenyl, azoferrocene, starting material, and some N-acetyldiferrocenylamine, m. 176° (heptane). This and LiAlH4 in Et2O 6 h. gave after an aqueous treatment 8.3% N-ethyldiferrocenylamine, m. 149-9.5°, and yellow (70%) diferrocenylamine, m. 152-3° (aqueous EtOH). This and Et3O+BF4- 5-10 min. at room temperature gave 56% ethyldiferrocenylamine, identical with the above. N-Benzoylferrocenylamine in THF added to LiAlH4 and refluxed 6 h. under N gave after an aqueous treatment 86% benzylferrocenylamine, m. 125°; benzoyl derivative m. 134.5-5.5°. The amine and Et3O+BF4- in CH2Cl2 gave in 5 min. refluxing 81% ethylbenzylferrocenylamine, m. 48-8.5°. N-Acetylferrocenylamine was reduced with LiAlH4 in Et2O to 94% ethylferrocenylamine m. 56.5-8°, identical with the specimen formed from ferrocenylamine and Et3O+BF4-.

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Thiazolidine – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1273-73-0, is researched, Molecular C10BrFe, about Ferrocene and related compounds. VIII. Internal rotation of the ferrocene molecule, the main research direction is DIPOLE MOMENT FERROCENES; FERROCENES DIPOLE MOMENT; INTERNAL ROTATION FERROCENES; ROTATION INTERNAL FERROCENES.Application In Synthesis of Bromoferrocene.

cf. CA 59, 5195h. The dipole moments of chloro- and bromoferrocene, measured at 20°, and of 1,1-dichloro- and 1,1-dibromoferrocene, measured at +5 and -20 to +130°, resp., are nearly identical to those of the corresponding monohalobenzenes. The values obtained for the dipole moments of the dihaloferrocenes at various temperatures can be used to calculate the energy differences of the 3 min. of the potential energy curves of internal rotation corresponding to the 3 antiprismatic conformations. A comparison of the curves with those of 1,2-dihaloethanes reveals that the energy barriers of internal rotation are smaller in ferrocene than in ethane. Attempts were made to calculate the contours of the potential energy curves of ferrocene and its halogen derivatives

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Thiazolidine – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Bromoferrocene, is researched, Molecular C10BrFe, CAS is 1273-73-0, about Dipole moments and internal rotation in 1,1′-dihaloferrocenes, the main research direction is dipole ferrocene halo rotation.Name: Bromoferrocene.

The dipole moments of bromoferrocene, iodoferrocene, 1,1′-dibromoferrocene, and 1-1′-diiodoferrocene have been measured in C6H6. They indicate that the potential barrier between the cis and trans forms, which is very small for 1,1′-dichloroferrocene, increases for 1,1′-dibromo- and 1,1′-diiodoferrocene. The potential energy function shows min. at 36°, 108° and 180°. The differences ΔE1 = E36° – E180° for the series have been calculated on the assumption that the min. at 180° and 108° are equal. The values obtained are consistent with increasing steric hindrance in the series Cl, Br, I.

If you want to learn more about this compound(Bromoferrocene)Name: Bromoferrocene, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1273-73-0).

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Postnov, V. N.; Klimova, E. I.; Meleshonkova, N. N.; Bolesov, I. G. published the article 《Ring opening of ferrocenyl-substituted cyclopropanes》. Keywords: cyclopropane ferrocenyl ring cleavage; butadiene cationic ferrocenyl formation cyclodimerization.They researched the compound: Bromoferrocene( cas:1273-73-0 ).Recommanded Product: 1273-73-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1273-73-0) here.

Treating a mixture of isomeric ferrocenyl-substituted cyclopropanes I (R = Fc throughout this abstract) with excess Ph3CBF4 in CH2Cl2 gave a 2:1 mixture of endo and exo isomers of diferrocenyl-substituted cyclohexene II, formed by cyclodimerization of the initially formed butadiene. Cleavage of 3-methyl-3-ferrocenylcyclopropene with CF3CO2H followed by trapping with excess Me2NPh gave a mixture of E- and Z-4-Me2NC6H4CH2CH:CRMe. A mechanism involving ferrocenyl-stabilized carbocation formation is proposed.

There is still a lot of research devoted to this compound(SMILES：Br[C-]12[Fe+2]3456789([C-]%10C6=C7C8=C9%10)C1=C3C4=C25)Recommanded Product: 1273-73-0, and with the development of science, more effects of this compound(1273-73-0) can be discovered.

Reference:
Thiazolidine – Wikipedia,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Syntheses based on organic derivatives of mercury. I. Reaction of mercurated ferrocenes with copper salts, published in 1966, which mentions a compound: 1273-73-0, mainly applied to , Product Details of 1273-73-0.

Mercurated products of ferrocene were separated as follows; dilution of the reaction mixture with H2O gave ferrocenylmercuric acetate, m. 115-16°; treatment with KBr gave bromomercuriferrocene, decomposed at 184-6°, after extraction with (CH2Cl)2 and treatment of the extracted material with petroleum ether. Extraction of the crude products with Me2CO gave 1,3-bis(bromomercuri)ferrocene, a yellow powder. Chlormercuriferrocene heated in Me2CO with CuCl2.2H2O and H2O 10 min. gave 58% chloroferrocene, m. 58-9°, CuBr2 similarly gave 69% bromoferrocene, m. 32-3°. 1,1′-Bis(chloromercuri)ferrocene and CuCl2 similarly gave 17% 1,1′-dichloroferrocene, m. 75-7°, and 1-chloro-1′-chloromercuriferrocene, m. 141-3°, separated on Al2O3 by elution with C6H6 and heptane. Similarly prepared was 1,1′-dibromoferrocene, m. 50°. Bromomercuriferrocene and Cu(OAc)2 heated to 130° in vacuo 2 hrs. gave 2% acetoxyferrocene, m. 63-4°; similarly chloromercuriferrocene and Cu phthalimide gave 40% N-ferrocenylphthalimide m. 152-4°. Dibromoferrocene heated with PhOK in the presence of powd. Cu in xylene 40 min. gave 20% 1,1-diphenoxyferrocene, m. 90.5-91°; bromoferrocene similarly gave phenoxyferrocene, m. 87-8°. 1,1′-bis(chloromercuri)ferrocene and Cu(SCN)2 heated 6 hrs. in C6H6 gave 30% thiocyanoferrocene m. 97-8°, and 1,1′-dithiocyanoferrocene, m. 114-15°. The former and MeMgI gave 90% methylthioferrocene (I), n25D 1.6488; methiodide, m. 106-7°. Similarly prepared was 1,1′-bis(methylthio)ferrocene, a liquid. I oxidized with H2O2 gave the sulfone, m. 73-4°.

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Reference:
Thiazolidine – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Bromoferrocene, is researched, Molecular C10BrFe, CAS is 1273-73-0, about Reactions of haloferrocenes. III. Reaction of haloferrocenes with copper(I) benzenethiolate, thiocyanate, acetate, and benzoate.Recommanded Product: Bromoferrocene.

Iodoferrocene reacted with copper(I) benzenethiolate in boiling pyridine to give ferrocenyl Ph sulfide in a quant. yield. The reaction of iodoferrocene with copper(I) thiocyanate gave diferrocenyl disulfide. The behavior of copper(I) acetate and benzoate toward haloferrocene was different from those of the other copper(I) salts: reactions in boiling pyridine gave the corresponding ferrocenyl ester, together with a small quantity of ferrocene, while the reaction in boiling toluene produced biferrocenyl as the main product. The reaction mechanism of the ferrocenyl ester and biferrocenyl formations was discussed.

There is still a lot of research devoted to this compound(SMILES：Br[C-]12[Fe+2]3456789([C-]%10C6=C7C8=C9%10)C1=C3C4=C25)Recommanded Product: Bromoferrocene, and with the development of science, more effects of this compound(1273-73-0) can be discovered.

Reference:
Thiazolidine – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《A New Approach To Predict the Biological Activity of Molecules Based on Similarity of Their Interaction Fields and the logP and logD Values: Application to Auxins》. Authors are Bertosa, Branimir; Kojic-Prodic, Biserka; Wade, Rebecca C.; Ramek, Michael; Piperaki, Stavroula; Tsantili-Kakoulidou, Anna; Tomic, Sanja.The article about the compound:2-(7-Bromo-1H-indol-3-yl)acetic acidcas:63352-97-6,SMILESS:O=C(O)CC1=CNC2=C1C=CC=C2Br).Related Products of 63352-97-6. Through the article, more information about this compound (cas:63352-97-6) is conveyed.

The activity of a biol. compound is dependent both on specific binding to a target receptor and its ADME (Absorption, Distribution, Metabolism, Excretion) properties. A challenge to predict biol. activity is to consider both contributions simultaneously in deriving quant. models. We present a novel approach to derive QSAR models combining similarity anal. of mol. interaction fields (MIFs) with prediction of logP and/or logD. This new classification method is applied to a set of about 100 compounds related to the auxin plant hormone. The classification based on similarity of their interaction fields is more successful for the indole than the phenoxy compounds The classification of the phenoxy compounds is however improved by taking into account the influence of the logP and/or the logD values on biol. activity. With the new combined method, the majority (8 out of 10) of the previously misclassified derivatives of phenoxy acetic acid are classified in accord with their bioassays. The recently determined crystal structure of the auxin-binding protein 1 (ABP1) enabled validation of our approach. The results of docking a few auxin related compounds with different biol. activity to ABP1 correlate well with the classification based on similarity of MIFs only. Biol. activity is, however, better predicted by a combined similarity of MIFs + logP/logD approach.

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Reference:
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Bromoferrocene(SMILESS: Br[C-]12[Fe+2]3456789([C-]%10C6=C7C8=C9%10)C1=C3C4=C25,cas:1273-73-0) is researched.Application In Synthesis of 3,4-Dihydroisoquinoline. The article 《Synthesis, chemical reactivity and electrochemical behaviour of mono- and difluoro metallocenes》 in relation to this compound, is published in Journal of Organometallic Chemistry. Let’s take a look at the latest research on this compound (cas:1273-73-0).

Syntheses of mono- and 1,1′-difluoro-substituted metallocenes (ferrocene, ruthenocene) and of asym. 1,1′-disubstituted ferrocenes with one substituent being fluorine are described. Lithiation of metallocenes and subsequent addition of the fluorinating agent NFSI gave the fluorinated metallocenes after optimization of the exptl. conditions. All new compounds were comprehensively characterized and the cyclic voltammograms of fluoro- and 1,1′-difluoroferrocene were recorded and compared to other mono- and dihalogenated ferrocenes. Half-wave potentials of +106 mV and +220 mV vs. FcH0/+ were obtained for monofluorinated species and difluorinated ferrocene, resp. Both values are remarkably low compared to the other halogenated ferrocenes (Cl, Br, and I). Finally, 1-bromo-1′-fluoro-ferrocene turns out to be an ideal starting material for further fluoro-substituted ferrocene derivatives

There is still a lot of research devoted to this compound(SMILES：Br[C-]12[Fe+2]3456789([C-]%10C6=C7C8=C9%10)C1=C3C4=C25)Computed Properties of C10BrFe, and with the development of science, more effects of this compound(1273-73-0) can be discovered.

Reference:
Thiazolidine – Wikipedia,
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