Tag: M.W=400-500

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BCL6 INHIBITORS

The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity Formula (I) wherein X1, X2, R1, R2, R30, R31 and Ring A are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

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Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H831N | ChemSpider

Because a catalyst decreases the height of the energy barrier, Quality Control of 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Quality Control of 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile, Name is 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile, molecular formula is C19H11F3N2O4S. In a article，once mentioned of Quality Control of 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile

PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS

The present application provides the compounds of formula I or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein s, t, n, R1, R2, R3, R4, R5, and R6 are as described herein.

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Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H840N | ChemSpider

Application of 1055361-35-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1055361-35-7, Name is 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile, molecular formula is C19H11F3N2O4S. In a Article，once mentioned of 1055361-35-7

Regioselective reactions of organozinc reagents with 2,4- dichloroquinoline and 5,7-dichloropyrazolo[1,5-alpha]pyrimidine

Strategies for controlling the regioselective reactions between 2,4- dichloroquinoline and organozinc reagents are described. 2,4- Dichloroquinoline has been found to react with benzylic zinc and phenylzinc reagents in the presence of catalytic amounts of palladium complexes to exclusively give alpha-substituted products. Several metal salts were examined as an additive for gamma-selective coupling reactions. The most effective additive for selective coupling reaction at the gamma-position has been found to be LiCl. These conditions for alpha- or gamma-selective coupling reactions were applied to the reaction between 5,7-dichloropyrazolo[1,5-alpha]pyrimidine and a biphenylmethylzinc reagent in the synthesis of the angiotensin II receptor antagonists. This regioselectivity should be generally applicable to other alpha,gamma-dichloroazine systems.

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Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H934N | ChemSpider

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like Safety of 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile, Name is 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile. In a document type is Article, introducing its new discovery., Safety of 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile

Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives

A series of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline, and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives was designed, synthesised, and evaluated in vitro against three protozoan parasites (Plasmodium falciparum, Leishmania donovani, and Trypanosoma brucei brucei). Biological results showed antiprotozoal activity with IC50 values in the muM range. In addition, the in vitro cytotoxicity of these original molecules was assessed with human HepG2 cells. The quinoline 1c was identified as the most potent antimalarial candidate with a ratio of cytotoxic to antiparasitic activities of 97 against the P. falciparum CQ-sensitive strain 3D7. The quinazoline 3h was also identified as the most potent trypanosomal candidate with a selectivity index (SI) of 43 on T. brucei brucei strain. Moreover, as the telomeres of the parasites P. falciparum and Trypanosoma are possible targets of this kind of nitrogen heterocyclic compounds, we have also investigated stabilisation of the Plasmodium and Trypanosoma telomeric G-quadruplexes by our best compounds through FRET melting assays.

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Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H875N | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1055361-35-7, name is 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile, introducing its new discovery. Safety of 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile

The adenosine receptor subfamily consists of the adenosine A1, A2A, A2B, and A3 receptors, which are localized in a variety of tissues throughout the human body. It is, therefore, a challenge to develop receptor specific ligands with improved tissue selectivity. Allosteric modulators could have these therapeutic advantages over orthosteric ligands. In the present study, a series of 2,4-disubstituted quinolines were synthesized on the basis of the structure of LUF6000 (34). Compound 27 (LUF6096) was able to allosterically enhance agonist binding to a similar extent as 34. In addition, this new compound showed low, if any, orthosteric affinity for any of the adenosine receptors. In a functional assay, compound 27 showed improved activity in comparison to 34, as it increased both the intrinsic efficacy and the potency of the reference agonist Cl-IB-MECA at the human adenosine A 3 receptor.

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Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H891N | ChemSpider

Reference of 1055361-35-7, One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time.In a article, authors is , mentioned the application of Reference of 1055361-35-7, Name is 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile, molecular formula is C19H11F3N2O4S

An organometallic compound represented by Formula 1, an organic light-emitting device including the organometallic compound, and a diagnostic composition including the organometallic compound. wherein, in Formula 1, R1 to R12 and R19 are the same as described in the specification.

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Quinuclidine – Wikipedia,
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Transition-metal-catalyzed coupling reactions are useful tools for synthesizing aryl sulfur compounds. However, conventional transition-metal-catalyzed thiolation of aryl bromides and chlorides typically requires the use of strong base under elevated reaction temperature. Herein, we report the first examples of nickel-catalyzed electrochemical thiolation of aryl bromides and chlorides in the absence of an external base at room temperature using undivided electrochemical cells.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H900N | ChemSpider

Reference of 1055361-35-7, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, Reference of 1055361-35-7, name is 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile, introducing its new discovery.

This invention relates to certain N-heteroaryl compounds that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of the N-heteroaryl compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

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Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H834N | ChemSpider

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, SDS of cas: 1055361-35-7, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. SDS of cas: 1055361-35-7, Name is 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile, molecular formula is C19H11F3N2O4S. In a Article, authors is Dobish, Mark C.，once mentioned of SDS of cas: 1055361-35-7

Highly enantioselective halolactonizations have been developed that employ a chiral proton catalyst-N-iodosuccinimide (NIS) reagent system in which the Bronsted acid is used at catalyst loadings as low as 1 mol %. An approach that modulates the achiral counterion (equimolar to the neutral chiral ligand-proton complex present at low catalyst loadings) to optimize the enantioselection is documented for the first time in this transformation. In this way, unsaturated carboxylic acids are converted to gamma-lactones in high yields (up to 98% ee) using commercially available NIS.

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Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H886N | ChemSpider

Synthetic Route of 1055361-35-7, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, Synthetic Route of 1055361-35-7, name is 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile, introducing its new discovery.

An efficient procedure has been proposed for the synthesis of linear and angular phenyl-substituted dibenzonaphthyridines from anilinoquinolines and benzoic acid in up to 85% yield using Eaton?s reagent (a solution of phosphorous pentoxide in methanesulfonic acid) as condensing agent instead of polyphosphoric acid which previously afforded less than 50% yield of the same compounds. Apart from benzoic acid, ethyl benzoate and benzoyl chloride can be used in the synthesis of dibenzonaphthyridines according to the proposed procedure, but the yields are lower.

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Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H932N | ChemSpider