2682-49-7, Name is Thiazolidin-2-one, belongs to thiazolidine compound, is a common compound. Safety of Thiazolidin-2-oneIn an article, once mentioned the new application about 2682-49-7.
Synthesis, pharmacological evaluation and structure-activity relationship of recently discovered enzyme antagonist azoles
Global people are suffering from the legion of diseases. Cytotoxic property of the chemical compound would not solely influence effective drug properties and reduce unnecessary side effects. Proteins/enzymes responsible for microbe proliferation or survival are specifically targeted and inhibited successfully making the cells to undergo apoptosis. Furthermore, isoforms of essential enzymes have distinct physiological functions; thereby inhibition of essential enzyme isoforms is an apt way to the clinical approach of disease neutralization. Drugs are designed so as to play significant roles such as signaling pathways in the oncogenic process including cell proliferation, invasion, and angiogenesis. The present review comprises collective information of the recent synthesis of various organic drug compounds in brief, which could inhibit particular enzyme. The review also covers the correlation of the structure of a drug molecule designed and its inhibitory activity. Also, the most significant enzyme inhibitors are highlighted and structural moieties/core units responsible for remarkable inhibitory values are emphasized.Natural product chemistry; Organic chemistry; Enzyme inhibitors; Carbonic anhydrase; COX; Pyrazole; Thiazole
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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H269N | ChemSpider