Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: C15H12O, 94-41-7, Name is Chalcone, molecular formula is C15H12O, belongs to thiazolidines compound. In a document, author is Sayeed, Faizan, introduce the new discover.
ANALGESIC AND ANTI INFLAMMATORY ACTIVITY OF NEW SUBSTITUTED THIAZOLIDIN-4-ONE DERIVATIVES
4-thiazolidinones are among the most extensively investigated class of organic compounds. Thiazolidin-4-one has been considered as magic moiety, which is a core structure in various synthetic pharmaceuticals displaying a broad spectrum of biological activities. They are widely used as anti-inflammatory, anticonvulsant, analgesic, antimicrobial, anti-HIV, CNS depressant, carcinostatic, antihypertensive and cytotoxic. In view of the wide spectrum activities of condensed 4-thiazolidinones, itwas thought worthwhile to undertake the synthesis of heterocyclic systems in which 4-thiazolidinone nucleus is linked to another biologically active moiety. Semicarbazide/Thiosemicarbazide was reacted with benzoyl chloride to obtain N-hydrazinocarbonyl benzene-1-carboxamide/N-hydrazinocarbothioyl benzene-1 carboxamide respectively. These were then condensed with various aldehydes to yield the intermediate Schiff bases. Thiazolidin-4-ones were prepared by the reaction of Schiff bases with mercaptoacetic acid in dry benzene by refluxing for 16-18 hours. The purity of the compounds synthesized was established by TLC. The synthesized derivatives were characterized by FT-IR, (HNMR)-H-1 and Mass spectral analysis. All the derivatives synthesized were screened for their analgesic and anti inflammatory potency. The compounds 3A3, 3A5,3B2, 3B6 have shown equipotent analgesic activity when compared to standard Ibuprofen. The compounds 3A2, 3A5, 3B2, and 3B3 have been evaluated for their antiinflammatory properties at a dose of 50 mg/kg using carrageenan induced rat paw edema method. All the tested compounds exhibited significant anti-inflammatory activity in acute inflammatory models in rats. Compounds 3A2, 3A5, 3B2, and 3B3 exhibited significant reduction in edema volume when compared to standard Ibuprofen.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 94-41-7. Formula: C15H12O.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com