Recently I am researching about BIOEVALUATION, Saw an article supported by the National Natural Science Funds of ChinaNational Natural Science Foundation of China (NSFC) [21662014, 21967009]; Natural Science Foundation of Jiangxi, ChinaNatural Science Foundation of Jiangxi Province [20181BBG70003, 20181ACB20025, 20192BAB215061]; Science and Technology Project [GJJ190583]. Recommanded Product: 1,1,1-Triethoxyethane. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zhang, BL; Liu, XB; Xiong, HH; Zhang, Q; Sun, X; Yang, ZH; Xu, S; Zheng, PW; Zhu, WF. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane
Two series of [1,2,4]triazolo[4,3-a]pyrazine derivatives bearing 4-oxo-pyridazinone moieties (compounds 21a-l and 22a-l) were designed and their IC50 values were evaluated against three cancer cell lines (A549, MCF-7 and HeLa) and c-Met kinase. Among them, the compound with most potential, 22i, exhibited excellent anti-tumor activity against A549, MCF-7 and HeLa cancer cell lines with IC50 values of 0.83 +/- 0.07 mu M, 0.15 +/- 0.08 mu M and 2.85 +/- 0.74 mu M, respectively, and it also possessed superior c-Met kinase inhibition ability at the nanomolar level (IC50 = 48 nM). Moreover, dose-dependent experiments, AO fluorescence staining, cell cycle assay, Annexin V-FITC/PI staining and docking studies were carried out in this study. The results demonstrated that compound 22i could be a potential c-Met kinase inhibitor.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com