Recently I am researching about ANTIDEPRESSANT; CYTOTOXICITY; FLAVONOIDS; INHIBITORS; ALKALOIDS; QUINOLONE, Saw an article supported by the Science and Technology Development Program of Jilin Provincial of China [20190201148JC]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Huang, ZH; Yin, LQ; Guan, LP; Li, ZH; Tan, C. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone. Category: thiazolidines
A group of 2-methyl-4-phenylquinoline-chalcone analogs (2a-2x) was synthesized and investigated for anti-depressant, anti-inflammatory, and analgesic effects as cyclooxygenase-2 inhibitors. Pharmacological experiments identified 24 analogs that exhibited anti-depressant, anti-inflammatory, and analgesic activities. In particular, compounds 2c, 2k, and 2w markedly shortened immobility times and exhibited the most anti-depressant activity. In addition, the mechanisms of action of the analogs 2c, 2k, and 2w were likely related to increased serotonin levels in the central nervous system. Compounds 2c, 2k, and 2w displayed reasonable cyclooxygenase-2 inhibitory effects (IC50 values from 0.21 to 0.29 mu mol/L) similar to celecoxib (IC50: 0.19 mu mol/L) in vitro. A molecular docking study of compound 2k also was conducted.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com