SDS of cas: 94-41-7. I found the field of Chemistry very interesting. Saw the article Enantioselective synthesis of P-chiral tertiary phosphine oxides with an ethynyl group via Cu(i)-catalyzed azide-alkyne cycloaddition published in 2020.0, Reprint Addresses Zhou, J (corresponding author), Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai, Peoples R China.; Zhou, J (corresponding author), East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China.; Zhou, J (corresponding author), Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China.. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone.
We report the highly enantioselective synthesis of P-chiral tertiary phosphine oxides featuring an ethynyl group via Cu(i)-catalyzed azide-alkyne cycloaddition. Newly developed chiral pyridinebisoxazolines (PYBOX) bearing a bulky C4 shielding group play an important role in achieving excellent enantioselectivity while suppressing side bis-triazoles formation in desymmetrizing prochiral diethynylphosphine oxides. Notably, by tuning the size of the C4 shielding group, it is possible to achieve excellent remote enantiofacial control in desymmetrizing phosphole oxide-diynes with the prochiral P-center farther from the ethynyl group by four covalent bonds. Time-dependent enantioselectivity is observed for these desymmetric CuAAC reactions, suggesting a synergic combination of a desymmetrization and a kinetic resolution, and our ligands prove to be better than unmodified PYBOX in both steps. This finding contributes to a highly enantioselective kinetic resolution of racemic ethynylphosphine oxides. The resulting chiral ethynylphosphine oxides are versatile P-chiral synthons, which can undergo a number of diversifying reactions to enrich structural diversity.
SDS of cas: 94-41-7. Welcome to talk about 94-41-7, If you have any questions, you can contact Zhu, RY; Chen, L; Hu, XS; Zhou, F; Zhou, J or send Email.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com